Detection of oxidative DNA damage in lymphocytes of patients with Alzheimer's disease

Oxidative damage to DNA may play an important role in both normal ageing and in neurodegenerative diseases. The deleterious consequences of excessive oxidations and the pathophysiological role of reactive oxygen species have been intensively studied in Alzheimer's disease. Although the role of...

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Veröffentlicht in:	Biomarkers 2004-03, Vol.9 (2), p.203-209
Hauptverfasser:	Kadioglu, Ela, Sardas, Semra, Aslan, Selcuk, Isik, Erdal, Karakaya, Ali Esat
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Alzheimer Disease - blood Alzheimer Disease - genetics Alzheimer Disease - metabolism Alzheimer's disease Biological and medical sciences Case-Control Studies Comet Assay Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Deoxyribonuclease (Pyrimidine Dimer) DNA Damage - physiology DNA-Formamidopyrimidine Glycosylase Escherichia coli Proteins Humans lesion-specific endonucleases Lymphocytes - metabolism Lymphocytes - pathology Medical sciences Neurology Oxidation-Reduction Oxidative Stress Purines - metabolism Pyrimidines - metabolism
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