A Case of Anti-p200 Pemphigoid with Autoantibodies against both a Novel 200-kD Dermal Antigen and the 290-kD Epidermolysis bullosa acquisita Antigen
Background: Anti-p200 pemphigoid with autoantibodies against the 200-kD dermal antigen has recently been identified. Objectives: Our patient showed small and tense blisters on her face and trunk. Methods: Immunoblotting (IB), using extracts of normal human epidermis and dermal skin, and immunoelectr...
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| Veröffentlicht in: | Dermatology (Basel) 2004-01, Vol.209 (2), p.145-148 |
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| creator | Furukawa, Hirotoshi Miura, Takako Takahashi, Masabumi Nakamura, Koichiro Kaneko, Fumio Ishii, Fumito Komai, Reiko Hashimoto, Takashi |
| description | Background: Anti-p200 pemphigoid with autoantibodies against the 200-kD dermal antigen has recently been identified. Objectives: Our patient showed small and tense blisters on her face and trunk. Methods: Immunoblotting (IB), using extracts of normal human epidermis and dermal skin, and immunoelectron microscopy (IEM), using normal human skin, were performed using the patient’s serum. Results: IB analysis showed that the patient’s serum did not react with 180-kD bullous pemphigoid (BP180) or BP230 antigens; however, IgG autoantibodies in the patient’s serum reacted with a 200-kD dermal antigen as well as the 290-kD epidermolysis bullosa acquisita (EBA) antigen. IEM showed that IgG antibodies in the patient’s serum bound to the lamina lucida, as well as both the lamina densa and sublamina densa. After the treatment with prednisolone, the 290-kD protein reactivity decreased rapidly; however, the 200-kD protein band was still observed. Conclusion: We describe a rare case with immunoreactive autoantibodies against both a novel dermal 200-kD autoantigen and the 290-kD EBA antigen. |
| doi_str_mv | 10.1159/000079601 |
| format | Article |
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Objectives: Our patient showed small and tense blisters on her face and trunk. Methods: Immunoblotting (IB), using extracts of normal human epidermis and dermal skin, and immunoelectron microscopy (IEM), using normal human skin, were performed using the patient’s serum. Results: IB analysis showed that the patient’s serum did not react with 180-kD bullous pemphigoid (BP180) or BP230 antigens; however, IgG autoantibodies in the patient’s serum reacted with a 200-kD dermal antigen as well as the 290-kD epidermolysis bullosa acquisita (EBA) antigen. IEM showed that IgG antibodies in the patient’s serum bound to the lamina lucida, as well as both the lamina densa and sublamina densa. After the treatment with prednisolone, the 290-kD protein reactivity decreased rapidly; however, the 200-kD protein band was still observed. Conclusion: We describe a rare case with immunoreactive autoantibodies against both a novel dermal 200-kD autoantigen and the 290-kD EBA antigen.</description><identifier>ISSN: 1018-8665</identifier><identifier>EISSN: 1421-9832</identifier><identifier>DOI: 10.1159/000079601</identifier><identifier>PMID: 15316171</identifier><language>eng</language><publisher>Basel, Switzerland: Karger</publisher><subject>Adult ; Antibiotics ; Antigens ; Autoantigens - analysis ; Biological and medical sciences ; Biopsy, Needle ; Bullous diseases of the skin ; Case Report ; Case studies ; Dermatology ; Drug Therapy, Combination ; Female ; Follow-Up Studies ; Humans ; Immunoblotting ; Immunohistochemistry ; Medical sciences ; Microscopy ; Microscopy, Immunoelectron ; Minocycline - therapeutic use ; Niacin - therapeutic use ; Pemphigoid, Bullous - immunology ; Pemphigoid, Bullous - pathology ; Prednisolone - therapeutic use ; Risk Assessment ; Severity of Illness Index ; Treatment Outcome</subject><ispartof>Dermatology (Basel), 2004-01, Vol.209 (2), p.145-148</ispartof><rights>2004 S. Karger AG, Basel</rights><rights>2004 INIST-CNRS</rights><rights>Copyright (c) 2004 S. Karger AG, Basel</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-c3a60d9e6e3943c1574c397be8e62905ebd65c66c2e0c2475b0bba6581bd4fed3</citedby><cites>FETCH-LOGICAL-c389t-c3a60d9e6e3943c1574c397be8e62905ebd65c66c2e0c2475b0bba6581bd4fed3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,2429,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16031676$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15316171$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Furukawa, Hirotoshi</creatorcontrib><creatorcontrib>Miura, Takako</creatorcontrib><creatorcontrib>Takahashi, Masabumi</creatorcontrib><creatorcontrib>Nakamura, Koichiro</creatorcontrib><creatorcontrib>Kaneko, Fumio</creatorcontrib><creatorcontrib>Ishii, Fumito</creatorcontrib><creatorcontrib>Komai, Reiko</creatorcontrib><creatorcontrib>Hashimoto, Takashi</creatorcontrib><title>A Case of Anti-p200 Pemphigoid with Autoantibodies against both a Novel 200-kD Dermal Antigen and the 290-kD Epidermolysis bullosa acquisita Antigen</title><title>Dermatology (Basel)</title><addtitle>Dermatology</addtitle><description>Background: Anti-p200 pemphigoid with autoantibodies against the 200-kD dermal antigen has recently been identified. Objectives: Our patient showed small and tense blisters on her face and trunk. Methods: Immunoblotting (IB), using extracts of normal human epidermis and dermal skin, and immunoelectron microscopy (IEM), using normal human skin, were performed using the patient’s serum. Results: IB analysis showed that the patient’s serum did not react with 180-kD bullous pemphigoid (BP180) or BP230 antigens; however, IgG autoantibodies in the patient’s serum reacted with a 200-kD dermal antigen as well as the 290-kD epidermolysis bullosa acquisita (EBA) antigen. IEM showed that IgG antibodies in the patient’s serum bound to the lamina lucida, as well as both the lamina densa and sublamina densa. After the treatment with prednisolone, the 290-kD protein reactivity decreased rapidly; however, the 200-kD protein band was still observed. Conclusion: We describe a rare case with immunoreactive autoantibodies against both a novel dermal 200-kD autoantigen and the 290-kD EBA antigen.</description><subject>Adult</subject><subject>Antibiotics</subject><subject>Antigens</subject><subject>Autoantigens - analysis</subject><subject>Biological and medical sciences</subject><subject>Biopsy, Needle</subject><subject>Bullous diseases of the skin</subject><subject>Case Report</subject><subject>Case studies</subject><subject>Dermatology</subject><subject>Drug Therapy, Combination</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Immunoblotting</subject><subject>Immunohistochemistry</subject><subject>Medical sciences</subject><subject>Microscopy</subject><subject>Microscopy, Immunoelectron</subject><subject>Minocycline - therapeutic use</subject><subject>Niacin - therapeutic use</subject><subject>Pemphigoid, Bullous - immunology</subject><subject>Pemphigoid, Bullous - pathology</subject><subject>Prednisolone - therapeutic use</subject><subject>Risk Assessment</subject><subject>Severity of Illness Index</subject><subject>Treatment Outcome</subject><issn>1018-8665</issn><issn>1421-9832</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqF0cFu1DAQAFALgWgpHDgjIasSlTgEbCd24uNq2wJSBRzgHI3tya7bJE7tBNT_4IMxu0srccEH29K8mbE1hLzk7B3nUr9nedVaMf6IHPNK8EI3pXic74w3RaOUPCLPUrrOSjS1fkqOuCy54jU_Jr9WdA0Jaejoapx9MQnG6Fccpq3fBO_oTz9v6WqZA-SoCc5jorABP6aZmpBjQD-HH9jTnFfcnNNzjAP0u1obHCmMjs5bpELvoheTdxmE_i75RM3S9yEBBXu7-ORn-Jv2nDzpoE_44nCekO-XF9_WH4urLx8-rVdXhS0bPecdFHMaFZa6Ki2XdWVLXRtsUOWGEo1T0iplBTIrqloaZgwo2XDjqg5deULO9nWnGG4XTHM7-GSx72HEsKRWqVoLycr_QsE0yw1Uhqf_wOuwxDF_ohVSCM6bmmX0do9sDClF7Nop-gHiXctZ-2eg7f1As319KLiYAd2DPEwwgzcHAMlC30UYrU8PTrEMdy97tXc3EDcY78G-zW_w8K6K</recordid><startdate>20040101</startdate><enddate>20040101</enddate><creator>Furukawa, Hirotoshi</creator><creator>Miura, Takako</creator><creator>Takahashi, Masabumi</creator><creator>Nakamura, Koichiro</creator><creator>Kaneko, Fumio</creator><creator>Ishii, Fumito</creator><creator>Komai, Reiko</creator><creator>Hashimoto, Takashi</creator><general>Karger</general><general>S. Karger AG</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7QO</scope><scope>7T5</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20040101</creationdate><title>A Case of Anti-p200 Pemphigoid with Autoantibodies against both a Novel 200-kD Dermal Antigen and the 290-kD Epidermolysis bullosa acquisita Antigen</title><author>Furukawa, Hirotoshi ; Miura, Takako ; Takahashi, Masabumi ; Nakamura, Koichiro ; Kaneko, Fumio ; Ishii, Fumito ; Komai, Reiko ; Hashimoto, Takashi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-c3a60d9e6e3943c1574c397be8e62905ebd65c66c2e0c2475b0bba6581bd4fed3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adult</topic><topic>Antibiotics</topic><topic>Antigens</topic><topic>Autoantigens - analysis</topic><topic>Biological and medical sciences</topic><topic>Biopsy, Needle</topic><topic>Bullous diseases of the skin</topic><topic>Case Report</topic><topic>Case studies</topic><topic>Dermatology</topic><topic>Drug Therapy, Combination</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Immunoblotting</topic><topic>Immunohistochemistry</topic><topic>Medical sciences</topic><topic>Microscopy</topic><topic>Microscopy, Immunoelectron</topic><topic>Minocycline - therapeutic use</topic><topic>Niacin - therapeutic use</topic><topic>Pemphigoid, Bullous - immunology</topic><topic>Pemphigoid, Bullous - pathology</topic><topic>Prednisolone - therapeutic use</topic><topic>Risk Assessment</topic><topic>Severity of Illness Index</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Furukawa, Hirotoshi</creatorcontrib><creatorcontrib>Miura, Takako</creatorcontrib><creatorcontrib>Takahashi, Masabumi</creatorcontrib><creatorcontrib>Nakamura, Koichiro</creatorcontrib><creatorcontrib>Kaneko, Fumio</creatorcontrib><creatorcontrib>Ishii, Fumito</creatorcontrib><creatorcontrib>Komai, Reiko</creatorcontrib><creatorcontrib>Hashimoto, Takashi</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Toxicology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>Biotechnology Research Abstracts</collection><collection>Immunology Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Dermatology (Basel)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Furukawa, Hirotoshi</au><au>Miura, Takako</au><au>Takahashi, Masabumi</au><au>Nakamura, Koichiro</au><au>Kaneko, Fumio</au><au>Ishii, Fumito</au><au>Komai, Reiko</au><au>Hashimoto, Takashi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Case of Anti-p200 Pemphigoid with Autoantibodies against both a Novel 200-kD Dermal Antigen and the 290-kD Epidermolysis bullosa acquisita Antigen</atitle><jtitle>Dermatology (Basel)</jtitle><addtitle>Dermatology</addtitle><date>2004-01-01</date><risdate>2004</risdate><volume>209</volume><issue>2</issue><spage>145</spage><epage>148</epage><pages>145-148</pages><issn>1018-8665</issn><eissn>1421-9832</eissn><abstract>Background: Anti-p200 pemphigoid with autoantibodies against the 200-kD dermal antigen has recently been identified. Objectives: Our patient showed small and tense blisters on her face and trunk. Methods: Immunoblotting (IB), using extracts of normal human epidermis and dermal skin, and immunoelectron microscopy (IEM), using normal human skin, were performed using the patient’s serum. Results: IB analysis showed that the patient’s serum did not react with 180-kD bullous pemphigoid (BP180) or BP230 antigens; however, IgG autoantibodies in the patient’s serum reacted with a 200-kD dermal antigen as well as the 290-kD epidermolysis bullosa acquisita (EBA) antigen. IEM showed that IgG antibodies in the patient’s serum bound to the lamina lucida, as well as both the lamina densa and sublamina densa. After the treatment with prednisolone, the 290-kD protein reactivity decreased rapidly; however, the 200-kD protein band was still observed. Conclusion: We describe a rare case with immunoreactive autoantibodies against both a novel dermal 200-kD autoantigen and the 290-kD EBA antigen.</abstract><cop>Basel, Switzerland</cop><pub>Karger</pub><pmid>15316171</pmid><doi>10.1159/000079601</doi><tpages>4</tpages></addata></record> |
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| ispartof | Dermatology (Basel), 2004-01, Vol.209 (2), p.145-148 |
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| subjects | Adult Antibiotics Antigens Autoantigens - analysis Biological and medical sciences Biopsy, Needle Bullous diseases of the skin Case Report Case studies Dermatology Drug Therapy, Combination Female Follow-Up Studies Humans Immunoblotting Immunohistochemistry Medical sciences Microscopy Microscopy, Immunoelectron Minocycline - therapeutic use Niacin - therapeutic use Pemphigoid, Bullous - immunology Pemphigoid, Bullous - pathology Prednisolone - therapeutic use Risk Assessment Severity of Illness Index Treatment Outcome |
| title | A Case of Anti-p200 Pemphigoid with Autoantibodies against both a Novel 200-kD Dermal Antigen and the 290-kD Epidermolysis bullosa acquisita Antigen |
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