Developmental differences in H2O2‐induced oligodendrocyte cell death: role of glutathione, mitogen‐activated protein kinases and caspase 3

The molecular mechanisms underlying H2O2‐induced toxicity were characterized in rat oligodendrocyte cultures. While progenitor cells were more sensitive than mature oligodendrocytes to H2O2, the antioxidant, N‐acetyl‐l‐cysteine, blocked toxicity at both stages of development. Differentiated oligoden...

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Veröffentlicht in:	Journal of neurochemistry 2004-07, Vol.90 (2), p.392-404
Hauptverfasser:	Fragoso, Gabriela, Martínez‐Bermúdez, Ana Katherine, Liu, Hsueh‐Ning, Khorchid, Amani, Chemtob, Sylvain, Mushynski, Walter E., Almazan, Guillermina
Format:	Artikel
Sprache:	eng
Schlagworte:	Ageing, cell death apoptosis Biological and medical sciences caspases Cell physiology Fundamental and applied biological sciences. Psychology Isolated neuron and nerve. Neuroglia mitogen‐activated protein kinase Molecular and cellular biology N‐acetyl‐l‐cysteine oligodendrocytes oxidative stress Vertebrates: nervous system and sense organs
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