Successful treatment of multidrug-resistant tuberculosis following drug-induced hepatic necrosis requiring liver transplant [Case Study]
A 28-year-old female developed multidrug-resistant (MDR) tuberculous lymphadenitis following a trip to India. She was initially treated with a four-drug regimen of first-line anti-tuberculosis medications, but when sensitivities indicated resistance to isoniazid and rifampin, her regimen was altered...
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| Veröffentlicht in: | The international journal of tuberculosis and lung disease 2004-07, Vol.8 (7), p.905-909 |
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| creator | MARRA, F COX, V. C FITZGERALD, J. M MOADEBI, S ELWOOD, R. K |
| description | A 28-year-old female developed multidrug-resistant (MDR) tuberculous lymphadenitis following a trip to India. She was initially treated with a four-drug regimen of first-line anti-tuberculosis medications, but when sensitivities indicated resistance to isoniazid and rifampin, her regimen
was altered to ciprofloxacin (CFX), pyrazinamide (PZA) and ethambutol. She subsequently developed a rash, flu-like symptoms and fever, which progressed to acute hepatic necrosis despite discontinuation of medication. The clinical presentation and subsequent investigations suggested a
hypersensitivity reaction, possibly related to the quinolone. The patient subsequently had an orthoptic liver transplant; second-line anti-tuberculosis medications were restarted to which she responded clinically and radiologically. Our findings raise the possibility that the CFX and PZA
combination was responsible for the hepatic necrosis. The patient also illustrates that active, even MDR tuberculosis is not a contraindication to hepatic transplant. |
| format | Article |
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was altered to ciprofloxacin (CFX), pyrazinamide (PZA) and ethambutol. She subsequently developed a rash, flu-like symptoms and fever, which progressed to acute hepatic necrosis despite discontinuation of medication. The clinical presentation and subsequent investigations suggested a
hypersensitivity reaction, possibly related to the quinolone. The patient subsequently had an orthoptic liver transplant; second-line anti-tuberculosis medications were restarted to which she responded clinically and radiologically. Our findings raise the possibility that the CFX and PZA
combination was responsible for the hepatic necrosis. The patient also illustrates that active, even MDR tuberculosis is not a contraindication to hepatic transplant.</description><identifier>ISSN: 1027-3719</identifier><identifier>EISSN: 1815-7920</identifier><identifier>PMID: 15260286</identifier><language>eng</language><publisher>Paris, France: IUATLD</publisher><subject>Adult ; Adverse Events ; Allergic Hepatitis ; Anti-Infective Agents - administration & dosage ; Anti-Infective Agents - adverse effects ; Anti-Infective Agents - therapeutic use ; Antitubercular Agents - pharmacology ; Antitubercular Agents - therapeutic use ; Bacterial diseases ; Biological and medical sciences ; Chemical and Drug Induced Liver Injury ; Ciprofloxacin - administration & dosage ; Ciprofloxacin - adverse effects ; Ciprofloxacin - therapeutic use ; Drug Hypersensitivity ; Drug Resistance, Multiple ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Human bacterial diseases ; Humans ; Infectious diseases ; Liver - pathology ; Liver Transplant ; Liver Transplantation ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Medical sciences ; Multidrug Resistance ; Mycobacterium tuberculosis ; Necrosis ; Other diseases. Semiology ; Pneumology ; Pyrazinamide - administration & dosage ; Pyrazinamide - adverse effects ; Pyrazinamide - therapeutic use ; Respiratory system : syndromes and miscellaneous diseases ; Tuberculosis ; Tuberculosis and atypical mycobacterial infections ; Tuberculosis, Pulmonary - drug therapy</subject><ispartof>The international journal of tuberculosis and lung disease, 2004-07, Vol.8 (7), p.905-909</ispartof><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15916497$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15260286$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MARRA, F</creatorcontrib><creatorcontrib>COX, V. C</creatorcontrib><creatorcontrib>FITZGERALD, J. M</creatorcontrib><creatorcontrib>MOADEBI, S</creatorcontrib><creatorcontrib>ELWOOD, R. K</creatorcontrib><title>Successful treatment of multidrug-resistant tuberculosis following drug-induced hepatic necrosis requiring liver transplant [Case Study]</title><title>The international journal of tuberculosis and lung disease</title><addtitle>Int J Tuberc Lung Dis</addtitle><description>A 28-year-old female developed multidrug-resistant (MDR) tuberculous lymphadenitis following a trip to India. She was initially treated with a four-drug regimen of first-line anti-tuberculosis medications, but when sensitivities indicated resistance to isoniazid and rifampin, her regimen
was altered to ciprofloxacin (CFX), pyrazinamide (PZA) and ethambutol. She subsequently developed a rash, flu-like symptoms and fever, which progressed to acute hepatic necrosis despite discontinuation of medication. The clinical presentation and subsequent investigations suggested a
hypersensitivity reaction, possibly related to the quinolone. The patient subsequently had an orthoptic liver transplant; second-line anti-tuberculosis medications were restarted to which she responded clinically and radiologically. Our findings raise the possibility that the CFX and PZA
combination was responsible for the hepatic necrosis. The patient also illustrates that active, even MDR tuberculosis is not a contraindication to hepatic transplant.</description><subject>Adult</subject><subject>Adverse Events</subject><subject>Allergic Hepatitis</subject><subject>Anti-Infective Agents - administration & dosage</subject><subject>Anti-Infective Agents - adverse effects</subject><subject>Anti-Infective Agents - therapeutic use</subject><subject>Antitubercular Agents - pharmacology</subject><subject>Antitubercular Agents - therapeutic use</subject><subject>Bacterial diseases</subject><subject>Biological and medical sciences</subject><subject>Chemical and Drug Induced Liver Injury</subject><subject>Ciprofloxacin - administration & dosage</subject><subject>Ciprofloxacin - adverse effects</subject><subject>Ciprofloxacin - therapeutic use</subject><subject>Drug Hypersensitivity</subject><subject>Drug Resistance, Multiple</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Liver - pathology</subject><subject>Liver Transplant</subject><subject>Liver Transplantation</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Medical sciences</subject><subject>Multidrug Resistance</subject><subject>Mycobacterium tuberculosis</subject><subject>Necrosis</subject><subject>Other diseases. Semiology</subject><subject>Pneumology</subject><subject>Pyrazinamide - administration & dosage</subject><subject>Pyrazinamide - adverse effects</subject><subject>Pyrazinamide - therapeutic use</subject><subject>Respiratory system : syndromes and miscellaneous diseases</subject><subject>Tuberculosis</subject><subject>Tuberculosis and atypical mycobacterial infections</subject><subject>Tuberculosis, Pulmonary - drug therapy</subject><issn>1027-3719</issn><issn>1815-7920</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kcuKFDEUQAtRnHH0F6Q2uivITaeS1FLaJwwojK5EQiq5adOkqnryGBm_wM82Nd0NbswiuVwOJ_fxqLkECX0nBkoe15hQ0W0EDBfNs5T2hFAAEE-bC-gpJ1Tyy-bPTTEGU3IltDmizhPOuV1cO5WQvY1l10VMPmVd07mMGE0JS020bglh-eXnXftA-dkWg7b9iQedvWlnNPGBi3hbfFy54O8w1l_0nA5h9X3f6oTtTS72_sfz5onTIeGL03vVfHv_7uv2Y3f9-cOn7ZvrzjNCc2c1oxRdzwcHDBhz0jjkI0qgjo4goHcDQz4wpzkA09Bb7lCyQRO0XI-bq-b10XuIy23BlNXkk8FQC8KlJAVCSCbppoIvT2AZJ7TqEP2k4706z64Cr06ATkYHV_syPv3DDcDZICr39sjVGdTharVfSpxrj8oXnYNVfr_elBCmyPHIcyCUjrm-IKvmy_805mxaF77uW93JWVQjBSJpX0sBoSw6XXeqso5q91ulqvwLgjOuTQ</recordid><startdate>20040701</startdate><enddate>20040701</enddate><creator>MARRA, F</creator><creator>COX, V. C</creator><creator>FITZGERALD, J. M</creator><creator>MOADEBI, S</creator><creator>ELWOOD, R. K</creator><general>IUATLD</general><general>Union internationale contre la tuberculose et les maladies respiratoires</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QL</scope><scope>C1K</scope></search><sort><creationdate>20040701</creationdate><title>Successful treatment of multidrug-resistant tuberculosis following drug-induced hepatic necrosis requiring liver transplant [Case Study]</title><author>MARRA, F ; COX, V. C ; FITZGERALD, J. M ; MOADEBI, S ; ELWOOD, R. K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i402t-da422ef569f14144f8cfe6be812f2b1715f94e694fa6114a15d6fe849a0ed6ab3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adult</topic><topic>Adverse Events</topic><topic>Allergic Hepatitis</topic><topic>Anti-Infective Agents - administration & dosage</topic><topic>Anti-Infective Agents - adverse effects</topic><topic>Anti-Infective Agents - therapeutic use</topic><topic>Antitubercular Agents - pharmacology</topic><topic>Antitubercular Agents - therapeutic use</topic><topic>Bacterial diseases</topic><topic>Biological and medical sciences</topic><topic>Chemical and Drug Induced Liver Injury</topic><topic>Ciprofloxacin - administration & dosage</topic><topic>Ciprofloxacin - adverse effects</topic><topic>Ciprofloxacin - therapeutic use</topic><topic>Drug Hypersensitivity</topic><topic>Drug Resistance, Multiple</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Human bacterial diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Liver - pathology</topic><topic>Liver Transplant</topic><topic>Liver Transplantation</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>Medical sciences</topic><topic>Multidrug Resistance</topic><topic>Mycobacterium tuberculosis</topic><topic>Necrosis</topic><topic>Other diseases. Semiology</topic><topic>Pneumology</topic><topic>Pyrazinamide - administration & dosage</topic><topic>Pyrazinamide - adverse effects</topic><topic>Pyrazinamide - therapeutic use</topic><topic>Respiratory system : syndromes and miscellaneous diseases</topic><topic>Tuberculosis</topic><topic>Tuberculosis and atypical mycobacterial infections</topic><topic>Tuberculosis, Pulmonary - drug therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MARRA, F</creatorcontrib><creatorcontrib>COX, V. C</creatorcontrib><creatorcontrib>FITZGERALD, J. M</creatorcontrib><creatorcontrib>MOADEBI, S</creatorcontrib><creatorcontrib>ELWOOD, R. K</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>The international journal of tuberculosis and lung disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MARRA, F</au><au>COX, V. C</au><au>FITZGERALD, J. M</au><au>MOADEBI, S</au><au>ELWOOD, R. K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Successful treatment of multidrug-resistant tuberculosis following drug-induced hepatic necrosis requiring liver transplant [Case Study]</atitle><jtitle>The international journal of tuberculosis and lung disease</jtitle><addtitle>Int J Tuberc Lung Dis</addtitle><date>2004-07-01</date><risdate>2004</risdate><volume>8</volume><issue>7</issue><spage>905</spage><epage>909</epage><pages>905-909</pages><issn>1027-3719</issn><eissn>1815-7920</eissn><abstract>A 28-year-old female developed multidrug-resistant (MDR) tuberculous lymphadenitis following a trip to India. She was initially treated with a four-drug regimen of first-line anti-tuberculosis medications, but when sensitivities indicated resistance to isoniazid and rifampin, her regimen
was altered to ciprofloxacin (CFX), pyrazinamide (PZA) and ethambutol. She subsequently developed a rash, flu-like symptoms and fever, which progressed to acute hepatic necrosis despite discontinuation of medication. The clinical presentation and subsequent investigations suggested a
hypersensitivity reaction, possibly related to the quinolone. The patient subsequently had an orthoptic liver transplant; second-line anti-tuberculosis medications were restarted to which she responded clinically and radiologically. Our findings raise the possibility that the CFX and PZA
combination was responsible for the hepatic necrosis. The patient also illustrates that active, even MDR tuberculosis is not a contraindication to hepatic transplant.</abstract><cop>Paris, France</cop><pub>IUATLD</pub><pmid>15260286</pmid><tpages>5</tpages></addata></record> |
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| subjects | Adult Adverse Events Allergic Hepatitis Anti-Infective Agents - administration & dosage Anti-Infective Agents - adverse effects Anti-Infective Agents - therapeutic use Antitubercular Agents - pharmacology Antitubercular Agents - therapeutic use Bacterial diseases Biological and medical sciences Chemical and Drug Induced Liver Injury Ciprofloxacin - administration & dosage Ciprofloxacin - adverse effects Ciprofloxacin - therapeutic use Drug Hypersensitivity Drug Resistance, Multiple Female Gastroenterology. Liver. Pancreas. Abdomen Human bacterial diseases Humans Infectious diseases Liver - pathology Liver Transplant Liver Transplantation Liver. Biliary tract. Portal circulation. Exocrine pancreas Medical sciences Multidrug Resistance Mycobacterium tuberculosis Necrosis Other diseases. Semiology Pneumology Pyrazinamide - administration & dosage Pyrazinamide - adverse effects Pyrazinamide - therapeutic use Respiratory system : syndromes and miscellaneous diseases Tuberculosis Tuberculosis and atypical mycobacterial infections Tuberculosis, Pulmonary - drug therapy |
| title | Successful treatment of multidrug-resistant tuberculosis following drug-induced hepatic necrosis requiring liver transplant [Case Study] |
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