The effect of recombinant IgG antibodies against the leucine-33 form of the platelet β3 integrin (HPA-1a) on platelet function

Summary Recombinant HPA-1a antibodies with Fc, mutated to remove destructive effector functions, have been developed as a potential therapy for fetomaternal alloimmune thrombocytopenia (FMAIT), via blockade of binding of human HPA-1a polyclonal antibodies to fetal HPA-1a1b platelets. We have assesse...

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Veröffentlicht in:	Thrombosis and haemostasis 2004, Vol.91 (4), p.743-754
Hauptverfasser:	Joutsi-Korhonen, Lotta, Preston, Sandy, Smethurst, Peter A., IJsseldijk, Martin, Schaffner-Reckinger, Elisabeth, Armour, Kathryn L., Watkins, Nicholas A., Clark, Michael R., de Groot, Philip G., Farndale, Richard W., Ouwehand, Willem H., Williamson, Lorna M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Blood coagulation. Blood cells Fundamental and applied biological sciences. Psychology Hematologic and hematopoietic diseases Medical sciences Molecular and cellular biology Platelet diseases and coagulopathies Platelets and Blood Cells
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