Expression analysis of the human kallikrein 7 (KLK7) in breast tumors: a new potential biomarker for prognosis of breast carcinoma
Summary Kallikreins are a subgroup of serine proteases that are involved in the post-translational processing of polypeptide precursors. Growing evidence suggests that many kallikreins are implicated in carcinogenesis. Human kallikrein gene 7 (KLK7; HSCCE) is a new member of the human kallikrein gen...
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| Veröffentlicht in: | Thrombosis and haemostasis 2004-01, Vol.91 (1), p.180-186 |
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| container_title | Thrombosis and haemostasis |
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| creator | Talieri, Maroulio Diamandis, Eleftherios P. Gourgiotis, Dimitrios Mathioudaki, Kostandina Scorilas, Andreas |
| description | Summary
Kallikreins are a subgroup of serine proteases that are involved in the post-translational processing of polypeptide precursors. Growing evidence suggests that many kallikreins are implicated in carcinogenesis. Human kallikrein gene 7 (KLK7; HSCCE) is a new member of the human kallikrein gene family. KLK7 is expressed in normal breast tissue and is up-regulated in breast cancer cells by estrogens and glucocorticoids. In the present study, expression of the KLK7 gene in 92 breast cancer tissues was analyzed by reverse transcription-PCR (RT-PCR) and direct sequencing of several samples. The results were correlated with other clinicopathological variables and patient outcome. KLK7 gene expression was significantly lower in breast cancer patients of low stage (I/II) (p = 0.011) and patients with positive progesterone receptors (p = 0.022). Survival analysis showed that breast cancer patients with KLK7 positive tumors have relatively shorter disease-free survival (DFS) and overall survival (OS) than patients with KLK7 negative tumors. These data suggest that KLK7 gene expression may be used as a marker of unfavorable prognosis for breast cancer patients. |
| doi_str_mv | 10.1160/TH03-05-0261 |
| format | Article |
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Kallikreins are a subgroup of serine proteases that are involved in the post-translational processing of polypeptide precursors. Growing evidence suggests that many kallikreins are implicated in carcinogenesis. Human kallikrein gene 7 (KLK7; HSCCE) is a new member of the human kallikrein gene family. KLK7 is expressed in normal breast tissue and is up-regulated in breast cancer cells by estrogens and glucocorticoids. In the present study, expression of the KLK7 gene in 92 breast cancer tissues was analyzed by reverse transcription-PCR (RT-PCR) and direct sequencing of several samples. The results were correlated with other clinicopathological variables and patient outcome. KLK7 gene expression was significantly lower in breast cancer patients of low stage (I/II) (p = 0.011) and patients with positive progesterone receptors (p = 0.022). Survival analysis showed that breast cancer patients with KLK7 positive tumors have relatively shorter disease-free survival (DFS) and overall survival (OS) than patients with KLK7 negative tumors. These data suggest that KLK7 gene expression may be used as a marker of unfavorable prognosis for breast cancer patients.</description><identifier>ISSN: 0340-6245</identifier><identifier>EISSN: 2567-689X</identifier><identifier>DOI: 10.1160/TH03-05-0261</identifier><identifier>PMID: 14691584</identifier><identifier>CODEN: THHADQ</identifier><language>eng</language><publisher>Stuttgart: Schattauer Verlag für Medizin und Naturwissenschaften</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Biomarkers, Tumor ; Blood coagulation. Blood cells ; Breast Neoplasms - diagnosis ; Breast Neoplasms - metabolism ; Carcinoma - diagnosis ; Carcinoma - metabolism ; Cellular Proteolysis and Oncology ; Cloning, Molecular ; Disease-Free Survival ; Female ; Fundamental and applied biological sciences. Psychology ; Glucocorticoids - metabolism ; Hematologic and hematopoietic diseases ; Humans ; Medical sciences ; Middle Aged ; Molecular and cellular biology ; Platelet diseases and coagulopathies ; Prognosis ; Receptors, Progesterone ; Receptors, Steroid - metabolism ; Reverse Transcriptase Polymerase Chain Reaction ; Time Factors ; Up-Regulation</subject><ispartof>Thrombosis and haemostasis, 2004-01, Vol.91 (1), p.180-186</ispartof><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c543t-24813a333529df361a5c824b176769908f5a2a8054ec15f729efb7fe5359ad4a3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.thieme-connect.de/products/ejournals/pdf/10.1160/TH03-05-0261.pdf$$EPDF$$P50$$Gthieme$$H</linktopdf><linktohtml>$$Uhttps://www.thieme-connect.de/products/ejournals/html/10.1160/TH03-05-0261$$EHTML$$P50$$Gthieme$$H</linktohtml><link.rule.ids>314,778,782,3007,4012,27906,27907,27908,54542,54543</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15801597$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14691584$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Talieri, Maroulio</creatorcontrib><creatorcontrib>Diamandis, Eleftherios P.</creatorcontrib><creatorcontrib>Gourgiotis, Dimitrios</creatorcontrib><creatorcontrib>Mathioudaki, Kostandina</creatorcontrib><creatorcontrib>Scorilas, Andreas</creatorcontrib><title>Expression analysis of the human kallikrein 7 (KLK7) in breast tumors: a new potential biomarker for prognosis of breast carcinoma</title><title>Thrombosis and haemostasis</title><addtitle>Thromb Haemost</addtitle><description>Summary
Kallikreins are a subgroup of serine proteases that are involved in the post-translational processing of polypeptide precursors. Growing evidence suggests that many kallikreins are implicated in carcinogenesis. Human kallikrein gene 7 (KLK7; HSCCE) is a new member of the human kallikrein gene family. KLK7 is expressed in normal breast tissue and is up-regulated in breast cancer cells by estrogens and glucocorticoids. In the present study, expression of the KLK7 gene in 92 breast cancer tissues was analyzed by reverse transcription-PCR (RT-PCR) and direct sequencing of several samples. The results were correlated with other clinicopathological variables and patient outcome. KLK7 gene expression was significantly lower in breast cancer patients of low stage (I/II) (p = 0.011) and patients with positive progesterone receptors (p = 0.022). Survival analysis showed that breast cancer patients with KLK7 positive tumors have relatively shorter disease-free survival (DFS) and overall survival (OS) than patients with KLK7 negative tumors. These data suggest that KLK7 gene expression may be used as a marker of unfavorable prognosis for breast cancer patients.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Biomarkers, Tumor</subject><subject>Blood coagulation. Blood cells</subject><subject>Breast Neoplasms - diagnosis</subject><subject>Breast Neoplasms - metabolism</subject><subject>Carcinoma - diagnosis</subject><subject>Carcinoma - metabolism</subject><subject>Cellular Proteolysis and Oncology</subject><subject>Cloning, Molecular</subject><subject>Disease-Free Survival</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glucocorticoids - metabolism</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Molecular and cellular biology</subject><subject>Platelet diseases and coagulopathies</subject><subject>Prognosis</subject><subject>Receptors, Progesterone</subject><subject>Receptors, Steroid - metabolism</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>Time Factors</subject><subject>Up-Regulation</subject><issn>0340-6245</issn><issn>2567-689X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqtkc-L1DAYhoso7rh68yy5CIpWk-ZH273JsrqyA15W8Ba-ZlKbnTYp-VLXvfqXmzKDC4I3T0nIk_cNz1cUzxl9x5ii768vKS-pLGml2INiU0lVl6ppvz0sNpQLWqpKyJPiCeINpUyJVj4uTphQLZON2BS_Ln7O0SK64Al4GO_QIQk9SYMlwzKBJ3sYR7eP1nlSk1dX26v6Ncn7LlrARNIyhYhnBIi3t2QOyfrkYCSdCxPEvY2kD5HMMXz34Rh9fGkgGucz9bR41MOI9tlxPS2-fry4Pr8st18-fT7_sC2NFDyVlWgYB865rNpdzxUDaZpKdKxWtWpb2vQSKmioFNYw2ddVa_uu7q3ksoWdAH5avD3kmhgQo-31HF3-5J1mVK8q9apSU6lXlRl_ccDnpZvs7h4-usvAyyMAaGDsI3jj8J6TDWWyrTP35sClwdnJ6puwxGwa_1XrDjSaAVKCxcY_kWmIYepWjxr8Tg9gp4AJ1rMJflWfL6IZ3A-rHeJidV1znYe4oIluTporITUO4VYPaRpzl_mPXThbk0f_dx__DeaL2wE</recordid><startdate>200401</startdate><enddate>200401</enddate><creator>Talieri, Maroulio</creator><creator>Diamandis, Eleftherios P.</creator><creator>Gourgiotis, Dimitrios</creator><creator>Mathioudaki, Kostandina</creator><creator>Scorilas, Andreas</creator><general>Schattauer Verlag für Medizin und Naturwissenschaften</general><general>Schattauer GmbH</general><general>Schattauer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>200401</creationdate><title>Expression analysis of the human kallikrein 7 (KLK7) in breast tumors: a new potential biomarker for prognosis of breast carcinoma</title><author>Talieri, Maroulio ; Diamandis, Eleftherios P. ; Gourgiotis, Dimitrios ; Mathioudaki, Kostandina ; Scorilas, Andreas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c543t-24813a333529df361a5c824b176769908f5a2a8054ec15f729efb7fe5359ad4a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Biomarkers, Tumor</topic><topic>Blood coagulation. Blood cells</topic><topic>Breast Neoplasms - diagnosis</topic><topic>Breast Neoplasms - metabolism</topic><topic>Carcinoma - diagnosis</topic><topic>Carcinoma - metabolism</topic><topic>Cellular Proteolysis and Oncology</topic><topic>Cloning, Molecular</topic><topic>Disease-Free Survival</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Glucocorticoids - metabolism</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Molecular and cellular biology</topic><topic>Platelet diseases and coagulopathies</topic><topic>Prognosis</topic><topic>Receptors, Progesterone</topic><topic>Receptors, Steroid - metabolism</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>Time Factors</topic><topic>Up-Regulation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Talieri, Maroulio</creatorcontrib><creatorcontrib>Diamandis, Eleftherios P.</creatorcontrib><creatorcontrib>Gourgiotis, Dimitrios</creatorcontrib><creatorcontrib>Mathioudaki, Kostandina</creatorcontrib><creatorcontrib>Scorilas, Andreas</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Thrombosis and haemostasis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Talieri, Maroulio</au><au>Diamandis, Eleftherios P.</au><au>Gourgiotis, Dimitrios</au><au>Mathioudaki, Kostandina</au><au>Scorilas, Andreas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression analysis of the human kallikrein 7 (KLK7) in breast tumors: a new potential biomarker for prognosis of breast carcinoma</atitle><jtitle>Thrombosis and haemostasis</jtitle><addtitle>Thromb Haemost</addtitle><date>2004-01</date><risdate>2004</risdate><volume>91</volume><issue>1</issue><spage>180</spage><epage>186</epage><pages>180-186</pages><issn>0340-6245</issn><eissn>2567-689X</eissn><coden>THHADQ</coden><abstract>Summary
Kallikreins are a subgroup of serine proteases that are involved in the post-translational processing of polypeptide precursors. Growing evidence suggests that many kallikreins are implicated in carcinogenesis. Human kallikrein gene 7 (KLK7; HSCCE) is a new member of the human kallikrein gene family. KLK7 is expressed in normal breast tissue and is up-regulated in breast cancer cells by estrogens and glucocorticoids. In the present study, expression of the KLK7 gene in 92 breast cancer tissues was analyzed by reverse transcription-PCR (RT-PCR) and direct sequencing of several samples. The results were correlated with other clinicopathological variables and patient outcome. KLK7 gene expression was significantly lower in breast cancer patients of low stage (I/II) (p = 0.011) and patients with positive progesterone receptors (p = 0.022). Survival analysis showed that breast cancer patients with KLK7 positive tumors have relatively shorter disease-free survival (DFS) and overall survival (OS) than patients with KLK7 negative tumors. These data suggest that KLK7 gene expression may be used as a marker of unfavorable prognosis for breast cancer patients.</abstract><cop>Stuttgart</cop><pub>Schattauer Verlag für Medizin und Naturwissenschaften</pub><pmid>14691584</pmid><doi>10.1160/TH03-05-0261</doi><tpages>7</tpages></addata></record> |
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| ispartof | Thrombosis and haemostasis, 2004-01, Vol.91 (1), p.180-186 |
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| source | MEDLINE; Thieme Connect Journals |
| subjects | Adult Aged Aged, 80 and over Biological and medical sciences Biomarkers, Tumor Blood coagulation. Blood cells Breast Neoplasms - diagnosis Breast Neoplasms - metabolism Carcinoma - diagnosis Carcinoma - metabolism Cellular Proteolysis and Oncology Cloning, Molecular Disease-Free Survival Female Fundamental and applied biological sciences. Psychology Glucocorticoids - metabolism Hematologic and hematopoietic diseases Humans Medical sciences Middle Aged Molecular and cellular biology Platelet diseases and coagulopathies Prognosis Receptors, Progesterone Receptors, Steroid - metabolism Reverse Transcriptase Polymerase Chain Reaction Time Factors Up-Regulation |
| title | Expression analysis of the human kallikrein 7 (KLK7) in breast tumors: a new potential biomarker for prognosis of breast carcinoma |
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