Microbial models of animal drug metabolism: Part 5. Microbial preparation of human hydroxylated metabolites of irbesartan
An exhaustive screening of fungal and microbial strains allowed to select the best microorganisms to produce in high yields some of the animal metabolites of an antihypertensive drug, irbesartan, in order to elucidate their structural and stereochemical characteristics. Among the microorganisms test...
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| Veröffentlicht in: | Journal of molecular catalysis. B, Enzymatic Enzymatic, 2004-06, Vol.29 (1-6), p.173-179 |
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| container_end_page | 179 |
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| container_issue | 1-6 |
| container_start_page | 173 |
| container_title | Journal of molecular catalysis. B, Enzymatic |
| container_volume | 29 |
| creator | Alexandre, Vanessa Ladril, Sophie Maurs, Michèle Azerad, Robert |
| description | An exhaustive screening of fungal and microbial strains allowed to select the best microorganisms to produce in high yields some of the animal metabolites of an antihypertensive drug, irbesartan, in order to elucidate their structural and stereochemical characteristics. Among the microorganisms tested, bacteria, and especially Streptomyces strains, were the most active producers of the main metabolites which included diastereomeric derivatives hydroxylated in the spirocyclopentane ring, open rearranged hydroxylated derivatives, and a putative N-glycosidic conjugate of irbesartan. |
| doi_str_mv | 10.1016/j.molcatb.2004.01.012 |
| format | Article |
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Microbial preparation of human hydroxylated metabolites of irbesartan</title><title>Journal of molecular catalysis. B, Enzymatic</title><description>An exhaustive screening of fungal and microbial strains allowed to select the best microorganisms to produce in high yields some of the animal metabolites of an antihypertensive drug, irbesartan, in order to elucidate their structural and stereochemical characteristics. Among the microorganisms tested, bacteria, and especially Streptomyces strains, were the most active producers of the main metabolites which included diastereomeric derivatives hydroxylated in the spirocyclopentane ring, open rearranged hydroxylated derivatives, and a putative N-glycosidic conjugate of irbesartan.</description><subject>Bacteria</subject><subject>Bioconversions. Hemisynthesis</subject><subject>Biological and medical sciences</subject><subject>Biotechnology</subject><subject>Drug metabolism</subject><subject>Fundamental and applied biological sciences. 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| identifier | ISSN: 1381-1177 |
| ispartof | Journal of molecular catalysis. B, Enzymatic, 2004-06, Vol.29 (1-6), p.173-179 |
| issn | 1381-1177 1873-3158 |
| language | eng |
| recordid | cdi_pascalfrancis_primary_15767286 |
| source | Elsevier ScienceDirect Journals |
| subjects | Bacteria Bioconversions. Hemisynthesis Biological and medical sciences Biotechnology Drug metabolism Fundamental and applied biological sciences. Psychology Fungi Glucoside Hydroxylation Methods. Procedures. Technologies Whole-cell biocatalysis |
| title | Microbial models of animal drug metabolism: Part 5. Microbial preparation of human hydroxylated metabolites of irbesartan |
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