SPINAL CORD INJURY: REVERSING THE INCORRECT CORTICAL MAPS BY INDUCTIVE LABILITY PROCEDURE
Within the brain-stem and on the cerebral cortex there are locomotor control centers arranged in a ladder-form control system. These centers are somatotopic, self-organizing neural network maps capable of simultaneously learning and task execution. In spinal cord injury (SCI) these self-organized ma...
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| Veröffentlicht in: | International journal of neuroscience 2004-06, Vol.114 (6), p.633-653 |
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| container_title | International journal of neuroscience |
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| creator | KRISHNAN, R. V. |
| description | Within the brain-stem and on the cerebral cortex there are locomotor control centers arranged in a ladder-form control system. These centers are somatotopic, self-organizing neural network maps capable of simultaneously learning and task execution. In spinal cord injury (SCI) these self-organized maps get erroneously re-organized and maladaptively stabilized. The extent and quality of sensory-motor recovery, if any appears, is affected by and compromised due to incorrect mapping processes. The treatment method based on inductive lability procedure (Krishnan, 2003a, 2003b, 2003c) uses botulinum toxin for the purpose. It recreates competition among synapses in a locomotor training-based corrective re-self-organization of the maps in various steps of the ladder. |
| doi_str_mv | 10.1080/00207450490440984 |
| format | Article |
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Diseases due to physical agents ; Locomotion - physiology ; Medical sciences ; Nerve Net - physiopathology ; Neuromuscular Junction - physiopathology ; Neuronal Plasticity - physiology ; Recovery of Function - drug effects ; Recovery of Function - physiology ; Spinal Cord Injuries - physiopathology ; Traumas. 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V.</creatorcontrib><title>SPINAL CORD INJURY: REVERSING THE INCORRECT CORTICAL MAPS BY INDUCTIVE LABILITY PROCEDURE</title><title>International journal of neuroscience</title><addtitle>Int J Neurosci</addtitle><description>Within the brain-stem and on the cerebral cortex there are locomotor control centers arranged in a ladder-form control system. These centers are somatotopic, self-organizing neural network maps capable of simultaneously learning and task execution. In spinal cord injury (SCI) these self-organized maps get erroneously re-organized and maladaptively stabilized. The extent and quality of sensory-motor recovery, if any appears, is affected by and compromised due to incorrect mapping processes. The treatment method based on inductive lability procedure (Krishnan, 2003a, 2003b, 2003c) uses botulinum toxin for the purpose. 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Diseases due to physical agents</subject><issn>0020-7454</issn><issn>1563-5279</issn><issn>1543-5245</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE9PwjAYhxujEYJ8AC9mF4_T_mWreoExYWYCGYNkp6XbujgzGOkghm9vJxg1Jpya9vc8b97-ALhG8A5BG95DiKFFGaQcUgq5Tc9AG7EeMRm2-DloN7mpAdoC3bouEn0nnGPbvgQtxDCkkFltEM1n3qTvG840GBre5GURRA9G4C7dYO5NRkY4dvWrDgPXCRso9BxNv_Znc2MQ6Wi4cEJv6Rp-f-D5XhgZs2DquMNF4F6Bi1yUtewezw4In93QGZv-dNQMMVNK8Na0OcuFFBDhBOWEEExQhhAXCFuEE9mTOOc4pdnX9gmDGSeslwpEUihtwUgHoMPYVFV1rWQeb1SxEmofIxg3RcX_itLOzcHZ7JKVzH6MYy0auD0Cok5FmSuxTov6F2cxhDHR3NOBK9Z5pVbio1JlFm_FvqzUt0RO7fH4R3-Toty-pULJ-L3aqbWu7cQvPgEc04vv</recordid><startdate>20040601</startdate><enddate>20040601</enddate><creator>KRISHNAN, R. 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V.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c432t-895faea012b1f333231d119a127393e6e2f92c4d02399b50d9356ca13c0e8a53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Animals</topic><topic>Anti-Dyskinesia Agents - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Botulinum Toxins - pharmacology</topic><topic>Brain Mapping</topic><topic>Cerebral Cortex - physiopathology</topic><topic>Humans</topic><topic>Injuries of the nervous system and the skull. Diseases due to physical agents</topic><topic>Locomotion - physiology</topic><topic>Medical sciences</topic><topic>Nerve Net - physiopathology</topic><topic>Neuromuscular Junction - physiopathology</topic><topic>Neuronal Plasticity - physiology</topic><topic>Recovery of Function - drug effects</topic><topic>Recovery of Function - physiology</topic><topic>Spinal Cord Injuries - physiopathology</topic><topic>Traumas. Diseases due to physical agents</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KRISHNAN, R. V.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>International journal of neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KRISHNAN, R. V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>SPINAL CORD INJURY: REVERSING THE INCORRECT CORTICAL MAPS BY INDUCTIVE LABILITY PROCEDURE</atitle><jtitle>International journal of neuroscience</jtitle><addtitle>Int J Neurosci</addtitle><date>2004-06-01</date><risdate>2004</risdate><volume>114</volume><issue>6</issue><spage>633</spage><epage>653</epage><pages>633-653</pages><issn>0020-7454</issn><eissn>1563-5279</eissn><eissn>1543-5245</eissn><coden>IJNUB7</coden><abstract>Within the brain-stem and on the cerebral cortex there are locomotor control centers arranged in a ladder-form control system. These centers are somatotopic, self-organizing neural network maps capable of simultaneously learning and task execution. In spinal cord injury (SCI) these self-organized maps get erroneously re-organized and maladaptively stabilized. The extent and quality of sensory-motor recovery, if any appears, is affected by and compromised due to incorrect mapping processes. The treatment method based on inductive lability procedure (Krishnan, 2003a, 2003b, 2003c) uses botulinum toxin for the purpose. It recreates competition among synapses in a locomotor training-based corrective re-self-organization of the maps in various steps of the ladder.</abstract><cop>London</cop><pub>Informa UK Ltd</pub><pmid>15204057</pmid><doi>10.1080/00207450490440984</doi><tpages>21</tpages></addata></record> |
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| source | Taylor & Francis:Master (3349 titles); MEDLINE; Taylor & Francis Medical Library - CRKN |
| subjects | Animals Anti-Dyskinesia Agents - pharmacology Biological and medical sciences Botulinum Toxins - pharmacology Brain Mapping Cerebral Cortex - physiopathology Humans Injuries of the nervous system and the skull. Diseases due to physical agents Locomotion - physiology Medical sciences Nerve Net - physiopathology Neuromuscular Junction - physiopathology Neuronal Plasticity - physiology Recovery of Function - drug effects Recovery of Function - physiology Spinal Cord Injuries - physiopathology Traumas. Diseases due to physical agents |
| title | SPINAL CORD INJURY: REVERSING THE INCORRECT CORTICAL MAPS BY INDUCTIVE LABILITY PROCEDURE |
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