Role of Tetrahydrobiopterin in Adrenocorticotropic Hormone-Induced Hypertension in the Rat

Adrenocorticotropic hormone (ACTH)-induced hypertension in the rat is characterized by nitric oxide deficiency. Tetrahydrobiopterin (BH4) is an essential cofactor for the enzyme nitric oxide synthase and glucocorticoids have been reported to reduce cytokine-induced BH4 production. Accordingly we hyp...

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Veröffentlicht in:	Clinical and experimental hypertension (1993) 2004-04, Vol.26 (3), p.231-241
Hauptverfasser:	Zhang, Y., Pang, T., Earl, J., Schyvens, C. G., McKenzie, K. U. S., Whitworth, Judith A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenocorticotropic hormone Adrenocorticotropic Hormone - pharmacology Animals Antioxidants - pharmacology Arterial hypertension. Arterial hypotension Biological and medical sciences Biopterins - analogs & derivatives Biopterins - pharmacology Blood and lymphatic vessels Blood pressure Blood Pressure - drug effects Body Weight - drug effects Cardiology. Vascular system Hypertension - chemically induced Hypertension - physiopathology Male Medical sciences Rat Rats Rats, Sprague-Dawley Tetrahydrobiopterin
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