Synthesis and biological evaluation of analogues of 7-chloro-4,5-dihydro-4-oxo-8-(1,2,4-triazol-4-yl)-1,2,4-triazolo[1,5-a]quinoxali ne-2-carboxylic acid (tqx-173) as novel selective AMPA receptor antagonists

Synthesis and biological evaluation of analogues of 7-chloro-4,5-dihydro-4-oxo-8-(1,2,4-triazol-4-yl)-1,2,4-triazolo[1,5-a]quinoxali ne-2-carboxylic acid (tqx-173) as novel selective AMPA receptor antagonists

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Veröffentlicht in:Journal of medicinal chemistry 2004, Vol.47 (1), p.262-272
Hauptverfasser: CATARZI, Daniela, COLOTTA, Vittoria, VARANO, Flavia, CALABRI, Francesca Romana, FILACCHIONI, Guido, GALLI, Alessandro, COSTAGLI, Chiara, CARLA, Vincenzo
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Sprache:eng
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Biological and medical sciences
Glutamatergic system (aspartate and other excitatory aminoacids)
Medical sciences
Neuropharmacology
Neurotransmitters. Neurotransmission. Receptors
Pharmacology. Drug treatments
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container_end_page 272
container_issue 1
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container_title Journal of medicinal chemistry
container_volume 47
creator CATARZI, Daniela
COLOTTA, Vittoria
VARANO, Flavia
CALABRI, Francesca Romana
FILACCHIONI, Guido
GALLI, Alessandro
COSTAGLI, Chiara
CARLA, Vincenzo
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source ACS Publications
subjects Biological and medical sciences
Glutamatergic system (aspartate and other excitatory aminoacids)
Medical sciences
Neuropharmacology
Neurotransmitters. Neurotransmission. Receptors
Pharmacology. Drug treatments
title Synthesis and biological evaluation of analogues of 7-chloro-4,5-dihydro-4-oxo-8-(1,2,4-triazol-4-yl)-1,2,4-triazolo[1,5-a]quinoxali ne-2-carboxylic acid (tqx-173) as novel selective AMPA receptor antagonists
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