Abnormal Coronary Function in Mice Deficient in α₁H T-type Ca2⁺ Channels

Calcium ion (Ca2+) influx through voltage-gated Ca2+channels is important for the regulation of vascular tone. Activation of L-type Ca2+channels initiates muscle contraction; however, the role of T-type Ca2+channels (T-channels) is not clear. We show that mice deficient in the$\alpha_{1H}$T-type Ca2...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2003-11, Vol.302 (5649), p.1416-1418
Hauptverfasser:	Chen, Chien-Chang, Lamping, Kathryn G., Nuno, Daniel W., Barresi, Rita, Prouty, Sally J., Lavoie, Julie L., Cribbs, Leanne L., England, Sarah K., Sigmund, Curt D., Weiss, Robert M., Williamson, Roger A., Hill, Joseph A., Campbell, Kevin P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Arteries Biological and medical sciences Blood vessels Calcium Coronary vessels Endothelial cells Fibrosis Fundamental and applied biological sciences. Psychology Heart Neurons Smooth muscle Smooth muscle myocytes Vertebrates: cardiovascular system
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