DNA MISMATCH REPAIR: Molecular Mechanisms and Biological Function

DNA mismatch repair (MMR) guards the integrity of the genome in virtually all cells. It contributes about 1000-fold to the overall fidelity of replication and targets mispaired bases that arise through replication errors, during homologous recombination, and as a result of DNA damage. Cells deficien...

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Veröffentlicht in:	Annual review of microbiology 2003-01, Vol.57 (1), p.579-608
Hauptverfasser:	Schofield, Mark J, Hsieh, Peggy
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphatases - metabolism Bacteria - genetics Bacteria - metabolism Bacterial Proteins - metabolism Base Pair Mismatch - physiology Biological and medical sciences cancer DNA DNA Damage - physiology DNA Repair - physiology DNA Replication - physiology DNA, Bacterial - metabolism DNA-Binding Proteins - metabolism Escherichia coli - genetics Escherichia coli - metabolism Escherichia coli Proteins - metabolism Fundamental and applied biological sciences. Psychology Genetics Medical sciences Meiosis - physiology Microbiology Models, Molecular mutagenesis MutL MutL Proteins MutS MutS DNA Mismatch-Binding Protein recombination Recombination, Genetic - physiology Tumors Virology
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