Inflammatory Role of Two Venom Components of Yellow Jackets (Vespula vulgaris): A Mast Cell Degranulating Peptide Mastoparan and Phospholipase A1

Background: Venom sac extract of yellow jackets Vespula vulgaris was toxic in mice when injected intraperitoneally but not toxic when injected subcutaneously. Necropsy showed the toxicity to be an inflammatory response. Methods: Venom peptide and protein fractions were tested to identify the inflamm...

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Veröffentlicht in:	International archives of allergy and immunology 2003-05, Vol.131 (1), p.25-32
Hauptverfasser:	King, Te Piao, Jim, Sui Yee, Wittkowski, Knut M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic Allergic diseases Animals Antibody Formation - drug effects Antibody Formation - immunology Antibody Specificity - drug effects Antibody Specificity - immunology Bee Venoms - chemistry Bee Venoms - isolation & purification Bee Venoms - pharmacology Bees - immunology Biological and medical sciences Dinoprostone - immunology Dose-Response Relationship, Immunologic Immunoglobulin E - drug effects Immunoglobulin E - immunology Immunoglobulin G - drug effects Immunoglobulin G - immunology Immunopathology Inflammation Mediators - chemistry Inflammation Mediators - immunology Inflammation Mediators - isolation & purification Medical sciences Mice Mice, Inbred BALB C Models, Animal Molecular Weight Original Paper Peptides - drug effects Peptides - immunology Peptides - isolation & purification Phospholipases A - chemistry Phospholipases A - isolation & purification Phospholipases A - pharmacology Phospholipases A1 Skin allergic diseases. Stinging insect allergies Tumor Necrosis Factor-alpha - immunology Tumor Necrosis Factor-alpha - metabolism Vespula vulgaris Wasp Venoms - chemistry Wasp Venoms - isolation & purification Wasp Venoms - pharmacology Wasps - immunology
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