Non-glutamate Type Pyrrolo[2, 3-d]pyrimidine Antifolates. III. Synthesis and Biological Properties of Nω-Masked Ornithine Analogs

The glutamic acid moiety of N-[4-[3(2, 4-diamino-7H-pyrrolo[2, 3-d]pyrimidin-5-yl)propyl]benzoyl]-L-glutamic acid (1b, TNP-351) and the related compound (1a), was replaced with various Nω-acyl-, sulfonyl-, carbamoyl- and aryl-2, ω-diaminoalkanoic acids, and the inhibitory effects of the resulting pr...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 2000/09/01, Vol.48(9), pp.1270-1280
Hauptverfasser:	ITOH, Fumio, YOSHIOKA, Yoshio, YUKISHIGE, Koichi, YOSHIDA, Sei, OOTSU, Koichiro, AKIMOTO, Hiroshi
Format:	Artikel
Sprache:	eng
Schlagworte:	antifolate Antineoplastic agents Biological and medical sciences dihydrofolate reductase inhibition General aspects Medical sciences methotrexate-resistant tumor Nω-masked ornithine Pharmacology. Drug treatments pyrrolo[2, 3-d]pyrimidine TNP-351
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