Blood coagulation and fibrinolytic factors in 105 patients with hemorrhagic syndrome caused by accidental contact with Lonomia obliqua caterpillar in Santa Catarina, Southern Brazil
Summary Haemostatic disorders caused by Lonomia obliqua caterpillars has reached epidemic proportions in southern Brazil. Here we evaluated coagulation and fibrinolysis in 105 patients after accidental contact with Lonomia obliqua caterpillars. Global coagulation tests were prolonged in most cases a...
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| Veröffentlicht in: | Thrombosis and haemostasis 2003-02, Vol.89 (2), p.355-364 |
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| creator | Zannin, Marlene Lourenço, Dayse M. Motta, Guacyara Dalla Costa, Luis R. Grando, Margaret Gamborgi, Geni P. Noguti, Maria A. Chudzinski-Tavassi, Ana M. |
| description | Summary
Haemostatic disorders caused by
Lonomia obliqua
caterpillars has reached epidemic proportions in southern Brazil. Here we evaluated coagulation and fibrinolysis in 105 patients after accidental contact with
Lonomia obliqua
caterpillars. Global coagulation tests were prolonged in most cases and patients were divided into 3 groups according to fibrinogen (Fg) level: 0.5 g/l (group A); 0.51–1.5 g/l (group B), >1.5 g/l (group C). There was a significant reduction of factors V, XIII, VIII and prekallikrein in group A, with no change in factors X, II and von Willebrand factor. Thrombin-antithrombin and prothrombin F1+2 were elevated in most patients. Antithrombin and protein S were not changed whereas protein C levels were reduced in group A. Plasminogen and alfa2-antiplasmin levels were significantly reduced in group A and D-Dimer levels were extremely high in all groups, showing that fibrinolysis had been activated, possibly secondary to fibrin production. Levels of t-PA were normal and PAI-1 was mildly elevated in group A. The platelet count remained above 150 × 10
9
platelets/ml in 97% of cases. In summary, our results suggest that
Lonomia obliqua
envenoming is characterized by a consumption coagulopathy and secondary fibrinolysis. |
| doi_str_mv | 10.1055/s-0037-1613453 |
| format | Article |
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Haemostatic disorders caused by
Lonomia obliqua
caterpillars has reached epidemic proportions in southern Brazil. Here we evaluated coagulation and fibrinolysis in 105 patients after accidental contact with
Lonomia obliqua
caterpillars. Global coagulation tests were prolonged in most cases and patients were divided into 3 groups according to fibrinogen (Fg) level: 0.5 g/l (group A); 0.51–1.5 g/l (group B), >1.5 g/l (group C). There was a significant reduction of factors V, XIII, VIII and prekallikrein in group A, with no change in factors X, II and von Willebrand factor. Thrombin-antithrombin and prothrombin F1+2 were elevated in most patients. Antithrombin and protein S were not changed whereas protein C levels were reduced in group A. Plasminogen and alfa2-antiplasmin levels were significantly reduced in group A and D-Dimer levels were extremely high in all groups, showing that fibrinolysis had been activated, possibly secondary to fibrin production. Levels of t-PA were normal and PAI-1 was mildly elevated in group A. The platelet count remained above 150 × 10
9
platelets/ml in 97% of cases. In summary, our results suggest that
Lonomia obliqua
envenoming is characterized by a consumption coagulopathy and secondary fibrinolysis.</description><identifier>ISSN: 0340-6245</identifier><identifier>EISSN: 2567-689X</identifier><identifier>DOI: 10.1055/s-0037-1613453</identifier><identifier>PMID: 12574817</identifier><identifier>CODEN: THHADQ</identifier><language>eng</language><publisher>Stuttgart: Schattauer Verlag für Medizin und Naturwissenschaften</publisher><subject>Animal poisons toxicology. Antivenoms ; Animals ; Antithrombin III - analysis ; Arthropod Venoms - adverse effects ; Biological and medical sciences ; Biomarkers ; Blood Coagulation Factors - analysis ; Blood Coagulation Tests ; Blood Proteins - analysis ; Brazil ; Disseminated Intravascular Coagulation - blood ; Disseminated Intravascular Coagulation - etiology ; Fibrin Fibrinogen Degradation Products - analysis ; Fibrinolysis ; Hematologic and hematopoietic diseases ; Hemorrhage - blood ; Hemorrhage - etiology ; Humans ; Larva ; Medical sciences ; Moths - growth & development ; Peptide Hydrolases - analysis ; Platelet Count ; Platelet diseases and coagulopathies ; Serine Endopeptidases - adverse effects ; Toxicology ; Wound Healing and Inflammation/Infection</subject><ispartof>Thrombosis and haemostasis, 2003-02, Vol.89 (2), p.355-364</ispartof><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c549t-3a3d10af54b6ac7b4f09fffdbef7010e21db67094709b9eb46235e86dd8b0e263</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0037-1613453.pdf$$EPDF$$P50$$Gthieme$$H</linktopdf><linktohtml>$$Uhttps://www.thieme-connect.de/products/ejournals/html/10.1055/s-0037-1613453$$EHTML$$P50$$Gthieme$$H</linktohtml><link.rule.ids>314,780,784,3017,3018,27924,27925,54559,54560</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14855812$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12574817$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zannin, Marlene</creatorcontrib><creatorcontrib>Lourenço, Dayse M.</creatorcontrib><creatorcontrib>Motta, Guacyara</creatorcontrib><creatorcontrib>Dalla Costa, Luis R.</creatorcontrib><creatorcontrib>Grando, Margaret</creatorcontrib><creatorcontrib>Gamborgi, Geni P.</creatorcontrib><creatorcontrib>Noguti, Maria A.</creatorcontrib><creatorcontrib>Chudzinski-Tavassi, Ana M.</creatorcontrib><title>Blood coagulation and fibrinolytic factors in 105 patients with hemorrhagic syndrome caused by accidental contact with Lonomia obliqua caterpillar in Santa Catarina, Southern Brazil</title><title>Thrombosis and haemostasis</title><addtitle>Thromb Haemost</addtitle><description>Summary
Haemostatic disorders caused by
Lonomia obliqua
caterpillars has reached epidemic proportions in southern Brazil. Here we evaluated coagulation and fibrinolysis in 105 patients after accidental contact with
Lonomia obliqua
caterpillars. Global coagulation tests were prolonged in most cases and patients were divided into 3 groups according to fibrinogen (Fg) level: 0.5 g/l (group A); 0.51–1.5 g/l (group B), >1.5 g/l (group C). There was a significant reduction of factors V, XIII, VIII and prekallikrein in group A, with no change in factors X, II and von Willebrand factor. Thrombin-antithrombin and prothrombin F1+2 were elevated in most patients. Antithrombin and protein S were not changed whereas protein C levels were reduced in group A. Plasminogen and alfa2-antiplasmin levels were significantly reduced in group A and D-Dimer levels were extremely high in all groups, showing that fibrinolysis had been activated, possibly secondary to fibrin production. Levels of t-PA were normal and PAI-1 was mildly elevated in group A. The platelet count remained above 150 × 10
9
platelets/ml in 97% of cases. In summary, our results suggest that
Lonomia obliqua
envenoming is characterized by a consumption coagulopathy and secondary fibrinolysis.</description><subject>Animal poisons toxicology. Antivenoms</subject><subject>Animals</subject><subject>Antithrombin III - analysis</subject><subject>Arthropod Venoms - adverse effects</subject><subject>Biological and medical sciences</subject><subject>Biomarkers</subject><subject>Blood Coagulation Factors - analysis</subject><subject>Blood Coagulation Tests</subject><subject>Blood Proteins - analysis</subject><subject>Brazil</subject><subject>Disseminated Intravascular Coagulation - blood</subject><subject>Disseminated Intravascular Coagulation - etiology</subject><subject>Fibrin Fibrinogen Degradation Products - analysis</subject><subject>Fibrinolysis</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Hemorrhage - blood</subject><subject>Hemorrhage - etiology</subject><subject>Humans</subject><subject>Larva</subject><subject>Medical sciences</subject><subject>Moths - growth & development</subject><subject>Peptide Hydrolases - analysis</subject><subject>Platelet Count</subject><subject>Platelet diseases and coagulopathies</subject><subject>Serine Endopeptidases - adverse effects</subject><subject>Toxicology</subject><subject>Wound Healing and Inflammation/Infection</subject><issn>0340-6245</issn><issn>2567-689X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqtkk2L1TAUhosoznV061Ky0ZUdk-ajvUvn4hdccDEK7sJJmk4zpEknSWe4_i__nyn34oDgzkUIIc857yFPquolwRcEc_4u1RjTtiaCUMbpo2rTcNHWotv-eFxtMGW4Fg3jZ9WzlG4wJoJt-dPqjDS8ZR1pN9WvSxdCj3SA68VBtsEj8D0arIrWB3fIVqMBdA4xIetRyURzwYzPCd3bPKLRTCHGEa4LmA6-j2EySMOSTI_UAYHWti80uJJRNp2PZfvgw2QBBeXs7QKlIps4W-cgrjlXUFi0gwxlDHiLrsKSRxM9uozw07rn1ZMBXDIvTvt59f3jh2-7z_X-66cvu_f7WnO2zTUF2hMMA2dKgG4VG_B2GIZemaHFBJuG9Eq0eMvKUlujmGgoN53o-06VW0HPqzfHvnMMt4tJWU42aVOm9CYsSbYUN6wRvIAXR1DHkFI0g5yjnSAeJMFyFSWTXEXJk6hS8OrUeVGT6R_wk5kCvD4BkDS4IYLXNj1wrOO8I03h6iOXR2smI2_CEn15k38H2yOf9Ag5w2Lin6Z5LPZUSCWnfAI5QnGbMqznVd4qXULUo70z0qa0GNl2nZzAL0lHO2dJqWhlGsO9HPPkSpb-j1lpNtqC-zuP_gYTcv74</recordid><startdate>20030201</startdate><enddate>20030201</enddate><creator>Zannin, Marlene</creator><creator>Lourenço, Dayse M.</creator><creator>Motta, Guacyara</creator><creator>Dalla Costa, Luis R.</creator><creator>Grando, Margaret</creator><creator>Gamborgi, Geni P.</creator><creator>Noguti, Maria A.</creator><creator>Chudzinski-Tavassi, Ana M.</creator><general>Schattauer Verlag für Medizin und Naturwissenschaften</general><general>Schattauer GmbH</general><general>Schattauer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20030201</creationdate><title>Blood coagulation and fibrinolytic factors in 105 patients with hemorrhagic syndrome caused by accidental contact with Lonomia obliqua caterpillar in Santa Catarina, Southern Brazil</title><author>Zannin, Marlene ; Lourenço, Dayse M. ; Motta, Guacyara ; Dalla Costa, Luis R. ; Grando, Margaret ; Gamborgi, Geni P. ; Noguti, Maria A. ; Chudzinski-Tavassi, Ana M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c549t-3a3d10af54b6ac7b4f09fffdbef7010e21db67094709b9eb46235e86dd8b0e263</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Animal poisons toxicology. Antivenoms</topic><topic>Animals</topic><topic>Antithrombin III - analysis</topic><topic>Arthropod Venoms - adverse effects</topic><topic>Biological and medical sciences</topic><topic>Biomarkers</topic><topic>Blood Coagulation Factors - analysis</topic><topic>Blood Coagulation Tests</topic><topic>Blood Proteins - analysis</topic><topic>Brazil</topic><topic>Disseminated Intravascular Coagulation - blood</topic><topic>Disseminated Intravascular Coagulation - etiology</topic><topic>Fibrin Fibrinogen Degradation Products - analysis</topic><topic>Fibrinolysis</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Hemorrhage - blood</topic><topic>Hemorrhage - etiology</topic><topic>Humans</topic><topic>Larva</topic><topic>Medical sciences</topic><topic>Moths - growth & development</topic><topic>Peptide Hydrolases - analysis</topic><topic>Platelet Count</topic><topic>Platelet diseases and coagulopathies</topic><topic>Serine Endopeptidases - adverse effects</topic><topic>Toxicology</topic><topic>Wound Healing and Inflammation/Infection</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zannin, Marlene</creatorcontrib><creatorcontrib>Lourenço, Dayse M.</creatorcontrib><creatorcontrib>Motta, Guacyara</creatorcontrib><creatorcontrib>Dalla Costa, Luis R.</creatorcontrib><creatorcontrib>Grando, Margaret</creatorcontrib><creatorcontrib>Gamborgi, Geni P.</creatorcontrib><creatorcontrib>Noguti, Maria A.</creatorcontrib><creatorcontrib>Chudzinski-Tavassi, Ana M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Thrombosis and haemostasis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zannin, Marlene</au><au>Lourenço, Dayse M.</au><au>Motta, Guacyara</au><au>Dalla Costa, Luis R.</au><au>Grando, Margaret</au><au>Gamborgi, Geni P.</au><au>Noguti, Maria A.</au><au>Chudzinski-Tavassi, Ana M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Blood coagulation and fibrinolytic factors in 105 patients with hemorrhagic syndrome caused by accidental contact with Lonomia obliqua caterpillar in Santa Catarina, Southern Brazil</atitle><jtitle>Thrombosis and haemostasis</jtitle><addtitle>Thromb Haemost</addtitle><date>2003-02-01</date><risdate>2003</risdate><volume>89</volume><issue>2</issue><spage>355</spage><epage>364</epage><pages>355-364</pages><issn>0340-6245</issn><eissn>2567-689X</eissn><coden>THHADQ</coden><abstract>Summary
Haemostatic disorders caused by
Lonomia obliqua
caterpillars has reached epidemic proportions in southern Brazil. Here we evaluated coagulation and fibrinolysis in 105 patients after accidental contact with
Lonomia obliqua
caterpillars. Global coagulation tests were prolonged in most cases and patients were divided into 3 groups according to fibrinogen (Fg) level: 0.5 g/l (group A); 0.51–1.5 g/l (group B), >1.5 g/l (group C). There was a significant reduction of factors V, XIII, VIII and prekallikrein in group A, with no change in factors X, II and von Willebrand factor. Thrombin-antithrombin and prothrombin F1+2 were elevated in most patients. Antithrombin and protein S were not changed whereas protein C levels were reduced in group A. Plasminogen and alfa2-antiplasmin levels were significantly reduced in group A and D-Dimer levels were extremely high in all groups, showing that fibrinolysis had been activated, possibly secondary to fibrin production. Levels of t-PA were normal and PAI-1 was mildly elevated in group A. The platelet count remained above 150 × 10
9
platelets/ml in 97% of cases. In summary, our results suggest that
Lonomia obliqua
envenoming is characterized by a consumption coagulopathy and secondary fibrinolysis.</abstract><cop>Stuttgart</cop><pub>Schattauer Verlag für Medizin und Naturwissenschaften</pub><pmid>12574817</pmid><doi>10.1055/s-0037-1613453</doi><tpages>10</tpages></addata></record> |
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| ispartof | Thrombosis and haemostasis, 2003-02, Vol.89 (2), p.355-364 |
| issn | 0340-6245 2567-689X |
| language | eng |
| recordid | cdi_pascalfrancis_primary_14855812 |
| source | MEDLINE; Thieme Connect |
| subjects | Animal poisons toxicology. Antivenoms Animals Antithrombin III - analysis Arthropod Venoms - adverse effects Biological and medical sciences Biomarkers Blood Coagulation Factors - analysis Blood Coagulation Tests Blood Proteins - analysis Brazil Disseminated Intravascular Coagulation - blood Disseminated Intravascular Coagulation - etiology Fibrin Fibrinogen Degradation Products - analysis Fibrinolysis Hematologic and hematopoietic diseases Hemorrhage - blood Hemorrhage - etiology Humans Larva Medical sciences Moths - growth & development Peptide Hydrolases - analysis Platelet Count Platelet diseases and coagulopathies Serine Endopeptidases - adverse effects Toxicology Wound Healing and Inflammation/Infection |
| title | Blood coagulation and fibrinolytic factors in 105 patients with hemorrhagic syndrome caused by accidental contact with Lonomia obliqua caterpillar in Santa Catarina, Southern Brazil |
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