Antituberculosis agents IV: In vitro antimycobacterial activity and cytotoxicity of N-piperazinyl quinolone derivatives containing 2-thienyl and 2-furyl moiety

A series of N-[2-(2-furyl)-2-oxoethyl], N-[2-(2-furyl)-2-oxyiminoethyl], N-[2-oxo-2-(2-thienyl)ethyl] and N-[2-oxyimino-2-(2-thienyl)ethyl] piperazinyl quinolones (1a-h; 2a-h) were evaluated for antituberculosis activity against M. tuberculosis H37Rv using the BACTEC 460 radiometric system and BACTE...

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Veröffentlicht in:	Pharmazie 2003-05, Vol.58 (5), p.347-348
Hauptverfasser:	Foroumadi, A., Soltani, F., Mirzaei, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Antineoplastic Agents - chemical synthesis Antineoplastic Agents - pharmacology Antitubercular Agents - chemical synthesis Antitubercular Agents - pharmacology Biological and medical sciences Cell Line, Tumor Cercopithecus aethiops Drug Screening Assays, Antitumor Furans - chemical synthesis Furans - pharmacology Humans Macrophages - drug effects Macrophages - microbiology Medical sciences Microbial Sensitivity Tests Mycobacterium tuberculosis - drug effects Pharmacology. Drug treatments Quinolones - chemical synthesis Quinolones - pharmacology Structure-Activity Relationship Thiophenes - chemical synthesis Thiophenes - pharmacology Vero Cells
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