Synthesis, characterization and mutagenicity of new cis-[Pt(2-substituted-benzimidazole)2Cl2] complexes
In this study, four new platinum(II) complexes with the structures cis-[Pt(Ligand)2Cl2] (ligand=2-(p-methoxy-/or-p-chlorobenzyl or p-methoxyphenyl)benzimidazol (1, 2, 4 respectively) and 5(6)-methyl-2-phenoxymethylbenzimidazole (3) were synthesized and characterized by their elemental analysis, and...
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| Veröffentlicht in: | Pharmazie 2003-05, Vol.58 (5), p.303-307 |
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| creator | Gümüş, F. Demirci, A. B. Özden, T. Eroğlu, H. Diril, N. |
| description | In this study, four new platinum(II) complexes with the structures cis-[Pt(Ligand)2Cl2] (ligand=2-(p-methoxy-/or-p-chlorobenzyl or p-methoxyphenyl)benzimidazol (1, 2, 4 respectively) and 5(6)-methyl-2-phenoxymethylbenzimidazole
(3) were synthesized and characterized by their elemental analysis, and IR and 1H NMR spectra. The potentials of the Pt(II) complexes for short-term bacterial mutagenicity were tested in reverse-mutation assays using Salmonella typhimurium frame-shift strain T 98 and
S. typhimurium TA 100 and TA 102 strains, which carry mutations particularly sensitive to reversion by DNA base-pair substitution. The tests were performed in the absence of S9 rat liver fraction. Among the complexes tested 1 had no mutagenic activity. Complex 4 was found
to be weakly mutagenic in TA 98 only. The Pt(II) complexes 2 and 3 were found to be mutagenic in TA 98, TA 100 and TA 102. |
| format | Article |
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(3) were synthesized and characterized by their elemental analysis, and IR and 1H NMR spectra. The potentials of the Pt(II) complexes for short-term bacterial mutagenicity were tested in reverse-mutation assays using Salmonella typhimurium frame-shift strain T 98 and
S. typhimurium TA 100 and TA 102 strains, which carry mutations particularly sensitive to reversion by DNA base-pair substitution. The tests were performed in the absence of S9 rat liver fraction. Among the complexes tested 1 had no mutagenic activity. Complex 4 was found
to be weakly mutagenic in TA 98 only. The Pt(II) complexes 2 and 3 were found to be mutagenic in TA 98, TA 100 and TA 102.</description><identifier>ISSN: 0031-7144</identifier><identifier>PMID: 12779045</identifier><identifier>CODEN: PHARAT</identifier><language>eng</language><publisher>Eschborn: Govi-Verlag</publisher><subject>Animals ; Antineoplastic Agents - chemical synthesis ; Antineoplastic Agents - pharmacology ; Benzimidazoles - chemical synthesis ; Benzimidazoles - pharmacology ; Biological and medical sciences ; Chemical mutagenesis ; Chemical Phenomena ; Chemistry, Physical ; Drug Screening Assays, Antitumor ; In Vitro Techniques ; Ligands ; Magnetic Resonance Spectroscopy ; Medical sciences ; Mutagenicity Tests ; Mutagens - chemical synthesis ; Mutagens - pharmacology ; Organoplatinum Compounds - chemical synthesis ; Organoplatinum Compounds - pharmacology ; Rats ; Salmonella typhimurium - genetics ; Spectrophotometry, Infrared ; Toxicology</subject><ispartof>Pharmazie, 2003-05, Vol.58 (5), p.303-307</ispartof><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>288,314,780,784</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14766601$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12779045$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gümüş, F.</creatorcontrib><creatorcontrib>Demirci, A. B.</creatorcontrib><creatorcontrib>Özden, T.</creatorcontrib><creatorcontrib>Eroğlu, H.</creatorcontrib><creatorcontrib>Diril, N.</creatorcontrib><title>Synthesis, characterization and mutagenicity of new cis-[Pt(2-substituted-benzimidazole)2Cl2] complexes</title><title>Pharmazie</title><addtitle>Pharmazie</addtitle><description>In this study, four new platinum(II) complexes with the structures cis-[Pt(Ligand)2Cl2] (ligand=2-(p-methoxy-/or-p-chlorobenzyl or p-methoxyphenyl)benzimidazol (1, 2, 4 respectively) and 5(6)-methyl-2-phenoxymethylbenzimidazole
(3) were synthesized and characterized by their elemental analysis, and IR and 1H NMR spectra. The potentials of the Pt(II) complexes for short-term bacterial mutagenicity were tested in reverse-mutation assays using Salmonella typhimurium frame-shift strain T 98 and
S. typhimurium TA 100 and TA 102 strains, which carry mutations particularly sensitive to reversion by DNA base-pair substitution. The tests were performed in the absence of S9 rat liver fraction. Among the complexes tested 1 had no mutagenic activity. Complex 4 was found
to be weakly mutagenic in TA 98 only. The Pt(II) complexes 2 and 3 were found to be mutagenic in TA 98, TA 100 and TA 102.</description><subject>Animals</subject><subject>Antineoplastic Agents - chemical synthesis</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Benzimidazoles - chemical synthesis</subject><subject>Benzimidazoles - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Chemical mutagenesis</subject><subject>Chemical Phenomena</subject><subject>Chemistry, Physical</subject><subject>Drug Screening Assays, Antitumor</subject><subject>In Vitro Techniques</subject><subject>Ligands</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Medical sciences</subject><subject>Mutagenicity Tests</subject><subject>Mutagens - chemical synthesis</subject><subject>Mutagens - pharmacology</subject><subject>Organoplatinum Compounds - chemical synthesis</subject><subject>Organoplatinum Compounds - pharmacology</subject><subject>Rats</subject><subject>Salmonella typhimurium - genetics</subject><subject>Spectrophotometry, Infrared</subject><subject>Toxicology</subject><issn>0031-7144</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU1LxDAQhntQXF39C9KLoGAhH03aHmX9hEUF9SQSpmnazdKmpUlXt7_erLviybnMHB4e5p3ZCw4RojhKcBxPgiNrlwgRTnh6EEwwSZIMxewwqF7Wxi2U1fYylAvoQTrV6xGcbk0IpgibwUGljJbarcO2DI36DKW20fuzOyeRHXLrtBucKqJcmVE3uoCxrdUFmdXkI5Rt09XqS9njYL-E2qqTXZ8Gb7c3r7P7aP509zC7mkea8sxFWSpzrIgqixLHQCgjBCspJSbAJU5JyRmVCXCaIy6zIsZZTCAvWEYzxmIAOg1Ot95uyBtViK7XDfRr8ZvYA2c7AKyEuuzB-Dh_XJxwzhH23PWW08bHdyCW7dAbv7qo2pUWnb9VA6Mg_sYC_RRLdwNiAnq3GajXPP6j0XJr2jxp8yOxYqlhXkgwSrGXZiwRhSphqJ1w0ItqFJbSb5mIj9k</recordid><startdate>20030501</startdate><enddate>20030501</enddate><creator>Gümüş, F.</creator><creator>Demirci, A. B.</creator><creator>Özden, T.</creator><creator>Eroğlu, H.</creator><creator>Diril, N.</creator><general>Govi-Verlag</general><general>Govi</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>20030501</creationdate><title>Synthesis, characterization and mutagenicity of new cis-[Pt(2-substituted-benzimidazole)2Cl2] complexes</title><author>Gümüş, F. ; Demirci, A. B. ; Özden, T. ; Eroğlu, H. ; Diril, N.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i369t-98cb1e2efdf14a235221eccc12a6c182f653c7a63b06c9d41942abd5939554aa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Animals</topic><topic>Antineoplastic Agents - chemical synthesis</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Benzimidazoles - chemical synthesis</topic><topic>Benzimidazoles - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Chemical mutagenesis</topic><topic>Chemical Phenomena</topic><topic>Chemistry, Physical</topic><topic>Drug Screening Assays, Antitumor</topic><topic>In Vitro Techniques</topic><topic>Ligands</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Medical sciences</topic><topic>Mutagenicity Tests</topic><topic>Mutagens - chemical synthesis</topic><topic>Mutagens - pharmacology</topic><topic>Organoplatinum Compounds - chemical synthesis</topic><topic>Organoplatinum Compounds - pharmacology</topic><topic>Rats</topic><topic>Salmonella typhimurium - genetics</topic><topic>Spectrophotometry, Infrared</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gümüş, F.</creatorcontrib><creatorcontrib>Demirci, A. B.</creatorcontrib><creatorcontrib>Özden, T.</creatorcontrib><creatorcontrib>Eroğlu, H.</creatorcontrib><creatorcontrib>Diril, N.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Pharmazie</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gümüş, F.</au><au>Demirci, A. B.</au><au>Özden, T.</au><au>Eroğlu, H.</au><au>Diril, N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis, characterization and mutagenicity of new cis-[Pt(2-substituted-benzimidazole)2Cl2] complexes</atitle><jtitle>Pharmazie</jtitle><addtitle>Pharmazie</addtitle><date>2003-05-01</date><risdate>2003</risdate><volume>58</volume><issue>5</issue><spage>303</spage><epage>307</epage><pages>303-307</pages><issn>0031-7144</issn><coden>PHARAT</coden><abstract>In this study, four new platinum(II) complexes with the structures cis-[Pt(Ligand)2Cl2] (ligand=2-(p-methoxy-/or-p-chlorobenzyl or p-methoxyphenyl)benzimidazol (1, 2, 4 respectively) and 5(6)-methyl-2-phenoxymethylbenzimidazole
(3) were synthesized and characterized by their elemental analysis, and IR and 1H NMR spectra. The potentials of the Pt(II) complexes for short-term bacterial mutagenicity were tested in reverse-mutation assays using Salmonella typhimurium frame-shift strain T 98 and
S. typhimurium TA 100 and TA 102 strains, which carry mutations particularly sensitive to reversion by DNA base-pair substitution. The tests were performed in the absence of S9 rat liver fraction. Among the complexes tested 1 had no mutagenic activity. Complex 4 was found
to be weakly mutagenic in TA 98 only. The Pt(II) complexes 2 and 3 were found to be mutagenic in TA 98, TA 100 and TA 102.</abstract><cop>Eschborn</cop><pub>Govi-Verlag</pub><pmid>12779045</pmid><tpages>5</tpages></addata></record> |
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| source | MEDLINE; IngentaConnect Free/Open Access Journals; EZB-FREE-00999 freely available EZB journals |
| subjects | Animals Antineoplastic Agents - chemical synthesis Antineoplastic Agents - pharmacology Benzimidazoles - chemical synthesis Benzimidazoles - pharmacology Biological and medical sciences Chemical mutagenesis Chemical Phenomena Chemistry, Physical Drug Screening Assays, Antitumor In Vitro Techniques Ligands Magnetic Resonance Spectroscopy Medical sciences Mutagenicity Tests Mutagens - chemical synthesis Mutagens - pharmacology Organoplatinum Compounds - chemical synthesis Organoplatinum Compounds - pharmacology Rats Salmonella typhimurium - genetics Spectrophotometry, Infrared Toxicology |
| title | Synthesis, characterization and mutagenicity of new cis-[Pt(2-substituted-benzimidazole)2Cl2] complexes |
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