Biphenylsulfonamide Endothelin Receptor Antagonists. 2. Discovery of 4‘-Oxazolyl Biphenylsulfonamides as a New Class of Potent, Highly Selective ETA Antagonists

The synthesis and structure−activity relationship (SAR) studies of a series of 4‘-oxazolyl-N-(3,4-dimethyl-5-isoxazolyl)[1,1‘-biphenyl]-2-sulfonamide derivatives as endothelin-A (ETA) receptor antagonists are described. The data reveal a remarkable improvement in potency and metabolic stability when...

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Veröffentlicht in:	Journal of medicinal chemistry 2000-08, Vol.43 (16), p.3111-3117
Hauptverfasser:	Murugesan, Natesan, Gu, Zhengxiang, Stein, Philip D, Spergel, Steven, Mathur, Arvind, Leith, Leslie, Liu, Eddie C.-K, Zhang, Rongan, Bird, Eileen, Waldron, Tom, Marino, Anthony, Morrison, Richard A, Webb, Maria L, Moreland, Suzanne, Barrish, Joel C
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Cardiovascular system Medical sciences Miscellaneous Pharmacology. Drug treatments
Online-Zugang:	Volltext
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