A Lipid-based Delivery System for Antisense Oligonucleotides Derived from a Hydrophobic Complex

Antisense oligodeoxynucleotides (ASOs) prevent expression of proteins by binding to specific regions of mRNA. This report investigates a potential lipid-based delivery system for ASO. A hydrophobic complex was recovered following addition of cationic lipids to ASOs in a Bligh and Dyer monophase [chl...

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Veröffentlicht in:	Journal of drug targeting 2002-12, Vol.10 (8), p.615-623
Hauptverfasser:	Wong, F.M.P., MacAdam, S.A., Kim, A., Oja, C., Ramsay, E.C., Bally, M.B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antisense Oligonucleotides B-cell Lymphoma Cells Biological and medical sciences Blotting, Western Cell Line Chemical Phenomena Chemistry, Physical DNA - chemistry Drug Carriers Fluorescein-5-isothiocyanate Fluorescent Dyes Gene Expression Regulation - drug effects General pharmacology Genes, bcl-2 - drug effects Humans Lipid-antisense Oligonucleotide Particles Lipids - chemistry Liposomes Lymphoma, B-Cell - pathology Medical sciences Oligonucleotides, Antisense - administration & dosage Oligonucleotides, Antisense - chemistry Oligonucleotides, Antisense - pharmacology Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Phosphatidylethanolamines - chemistry Plasmids Poly(ethylene Glycol)-conjugated Phosphatidylethanolamine Polyethylene Glycols - chemistry
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