Effects of Thioamide Substitutions on the Conformation and Stability of α- and 310-Helices

Thiopeptides, formed by replacing the amide oxygen atom with a sp2 sulfur atom, are useful in protein engineering and drug design because they confer resistance to enzymatic degradation and are predicted to be more rigid. This report describes our free molecular dynamics simulations with explicit wa...

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Veröffentlicht in:	Journal of the American Chemical Society 2002-05, Vol.124 (18), p.5222-5230
Hauptverfasser:	Tran, Zeng, Jun, Treutlein, Herbert, Burgess, Antony W
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Fundamental and applied biological sciences. Psychology Molecular biophysics Structure in molecular biology Tridimensional structure
Online-Zugang:	Volltext
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