Networks of spinal cord neurons cultured on microelectrode arrays: response to stimuli and homeostasis
The use of planar microelectrode arrays allows one to register the electrophysiological activity of cultured neurons under virtual non-invasive conditions for a long period of time (i.e. hours). Several neural networks in the developing central nervous system are spontaneously active and such behavi...
Gespeichert in:
| Hauptverfasser: | , , , , , , |
|---|---|
| Format: | Tagungsbericht |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 649 |
|---|---|
| container_issue | |
| container_start_page | 645 |
| container_title | |
| container_volume | |
| creator | Chiappalone, M. Davide, F. Grattarola, M. Pasa, S. Maura, G. Marcoli, M. Tedesco, M.B. |
| description | The use of planar microelectrode arrays allows one to register the electrophysiological activity of cultured neurons under virtual non-invasive conditions for a long period of time (i.e. hours). Several neural networks in the developing central nervous system are spontaneously active and such behavior seems to play an important role in subsequent maturation. Here we show how the bursting electrophysiological activity of cultured spinal cord neurons (15-18 DIV) from the chick embryo is affected by drugs which act on non-NMDA receptors. Interestingly enough, the effects are transient and the network seems to be able to recover its initial spontaneous rhythm. Similar results have been described in the literature in the case of spinal cord explants. Changes in the patterns of electrophysiological activity are described in detail. |
| doi_str_mv | 10.1109/ISPA.2001.938706 |
| format | Conference Proceeding |
| fullrecord | <record><control><sourceid>pascalfrancis_6IE</sourceid><recordid>TN_cdi_pascalfrancis_primary_14172738</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><ieee_id>938706</ieee_id><sourcerecordid>14172738</sourcerecordid><originalsourceid>FETCH-LOGICAL-i204t-1a7ed72174d4f5593b5f9d10695b113bf5c6ee2555f814bda9fc7eff9cb482ba3</originalsourceid><addsrcrecordid>eNo9kE1LAzEURQMiqLV7cZWNy9Zkkkwm7krxo1BUUNclk7xgdGYy5GWQ_nsLFe_mLO7hLi4hV5wtOWfmdvP2ulpWjPGlEY1m9Qm5MEqYWtdGsjMyR_xihwgjG2POSXiG8pPyN9IUKI5xsB11KXs6wJTTgNRNXZkyeJoG2keXE3TgSk4eqM3Z7vGOZsDxoAItiWKJ_dRFagdPP1MPCYvFiJfkNNgOYf7HGfl4uH9fPy22L4-b9Wq7iBWTZcGtBq8rrqWXQSkjWhWM56w2quVctEG5GqBSSoWGy9ZbE5yGEIxrZVO1VszIzXF3tOhsF7IdXMTdmGNv837HJdeVFs3Buz56EQD-6-Nj4he73WPt</addsrcrecordid><sourcetype>Index Database</sourcetype><iscdi>true</iscdi><recordtype>conference_proceeding</recordtype></control><display><type>conference_proceeding</type><title>Networks of spinal cord neurons cultured on microelectrode arrays: response to stimuli and homeostasis</title><source>IEEE Electronic Library (IEL) Conference Proceedings</source><creator>Chiappalone, M. ; Davide, F. ; Grattarola, M. ; Pasa, S. ; Maura, G. ; Marcoli, M. ; Tedesco, M.B.</creator><creatorcontrib>Chiappalone, M. ; Davide, F. ; Grattarola, M. ; Pasa, S. ; Maura, G. ; Marcoli, M. ; Tedesco, M.B.</creatorcontrib><description>The use of planar microelectrode arrays allows one to register the electrophysiological activity of cultured neurons under virtual non-invasive conditions for a long period of time (i.e. hours). Several neural networks in the developing central nervous system are spontaneously active and such behavior seems to play an important role in subsequent maturation. Here we show how the bursting electrophysiological activity of cultured spinal cord neurons (15-18 DIV) from the chick embryo is affected by drugs which act on non-NMDA receptors. Interestingly enough, the effects are transient and the network seems to be able to recover its initial spontaneous rhythm. Similar results have been described in the literature in the case of spinal cord explants. Changes in the patterns of electrophysiological activity are described in detail.</description><identifier>ISBN: 9539676940</identifier><identifier>ISBN: 9789539676948</identifier><identifier>DOI: 10.1109/ISPA.2001.938706</identifier><language>eng</language><publisher>Piscataway NJ: IEEE</publisher><subject>Biological and medical sciences ; Biological neural networks ; Central nervous system ; Drugs ; Electrodes ; Electrophysiology ; Embryo ; Fundamental and applied biological sciences. Psychology ; In vitro ; Microelectrodes ; Neurons ; Protocols ; Spinal cord ; Vertebrates: nervous system and sense organs</subject><ispartof>ISPA 2001. Proceedings of the 2nd International Symposium on Image and Signal Processing and Analysis. In conjunction with 23rd International Conference on Information Technology Interfaces (IEEE Cat, 2001, p.645-649</ispartof><rights>2002 INIST-CNRS</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://ieeexplore.ieee.org/document/938706$$EHTML$$P50$$Gieee$$H</linktohtml><link.rule.ids>309,310,780,784,789,790,2058,4050,4051,27925,54920</link.rule.ids><linktorsrc>$$Uhttps://ieeexplore.ieee.org/document/938706$$EView_record_in_IEEE$$FView_record_in_$$GIEEE</linktorsrc><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14172738$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>Chiappalone, M.</creatorcontrib><creatorcontrib>Davide, F.</creatorcontrib><creatorcontrib>Grattarola, M.</creatorcontrib><creatorcontrib>Pasa, S.</creatorcontrib><creatorcontrib>Maura, G.</creatorcontrib><creatorcontrib>Marcoli, M.</creatorcontrib><creatorcontrib>Tedesco, M.B.</creatorcontrib><title>Networks of spinal cord neurons cultured on microelectrode arrays: response to stimuli and homeostasis</title><title>ISPA 2001. Proceedings of the 2nd International Symposium on Image and Signal Processing and Analysis. In conjunction with 23rd International Conference on Information Technology Interfaces (IEEE Cat</title><addtitle>ISPA</addtitle><description>The use of planar microelectrode arrays allows one to register the electrophysiological activity of cultured neurons under virtual non-invasive conditions for a long period of time (i.e. hours). Several neural networks in the developing central nervous system are spontaneously active and such behavior seems to play an important role in subsequent maturation. Here we show how the bursting electrophysiological activity of cultured spinal cord neurons (15-18 DIV) from the chick embryo is affected by drugs which act on non-NMDA receptors. Interestingly enough, the effects are transient and the network seems to be able to recover its initial spontaneous rhythm. Similar results have been described in the literature in the case of spinal cord explants. Changes in the patterns of electrophysiological activity are described in detail.</description><subject>Biological and medical sciences</subject><subject>Biological neural networks</subject><subject>Central nervous system</subject><subject>Drugs</subject><subject>Electrodes</subject><subject>Electrophysiology</subject><subject>Embryo</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>In vitro</subject><subject>Microelectrodes</subject><subject>Neurons</subject><subject>Protocols</subject><subject>Spinal cord</subject><subject>Vertebrates: nervous system and sense organs</subject><isbn>9539676940</isbn><isbn>9789539676948</isbn><fulltext>true</fulltext><rsrctype>conference_proceeding</rsrctype><creationdate>2001</creationdate><recordtype>conference_proceeding</recordtype><sourceid>6IE</sourceid><sourceid>RIE</sourceid><recordid>eNo9kE1LAzEURQMiqLV7cZWNy9Zkkkwm7krxo1BUUNclk7xgdGYy5GWQ_nsLFe_mLO7hLi4hV5wtOWfmdvP2ulpWjPGlEY1m9Qm5MEqYWtdGsjMyR_xihwgjG2POSXiG8pPyN9IUKI5xsB11KXs6wJTTgNRNXZkyeJoG2keXE3TgSk4eqM3Z7vGOZsDxoAItiWKJ_dRFagdPP1MPCYvFiJfkNNgOYf7HGfl4uH9fPy22L4-b9Wq7iBWTZcGtBq8rrqWXQSkjWhWM56w2quVctEG5GqBSSoWGy9ZbE5yGEIxrZVO1VszIzXF3tOhsF7IdXMTdmGNv837HJdeVFs3Buz56EQD-6-Nj4he73WPt</recordid><startdate>2001</startdate><enddate>2001</enddate><creator>Chiappalone, M.</creator><creator>Davide, F.</creator><creator>Grattarola, M.</creator><creator>Pasa, S.</creator><creator>Maura, G.</creator><creator>Marcoli, M.</creator><creator>Tedesco, M.B.</creator><general>IEEE</general><general>IEEE Service Center</general><scope>6IE</scope><scope>6IL</scope><scope>CBEJK</scope><scope>RIE</scope><scope>RIL</scope><scope>IQODW</scope></search><sort><creationdate>2001</creationdate><title>Networks of spinal cord neurons cultured on microelectrode arrays: response to stimuli and homeostasis</title><author>Chiappalone, M. ; Davide, F. ; Grattarola, M. ; Pasa, S. ; Maura, G. ; Marcoli, M. ; Tedesco, M.B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i204t-1a7ed72174d4f5593b5f9d10695b113bf5c6ee2555f814bda9fc7eff9cb482ba3</frbrgroupid><rsrctype>conference_proceedings</rsrctype><prefilter>conference_proceedings</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Biological and medical sciences</topic><topic>Biological neural networks</topic><topic>Central nervous system</topic><topic>Drugs</topic><topic>Electrodes</topic><topic>Electrophysiology</topic><topic>Embryo</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>In vitro</topic><topic>Microelectrodes</topic><topic>Neurons</topic><topic>Protocols</topic><topic>Spinal cord</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>online_resources</toplevel><creatorcontrib>Chiappalone, M.</creatorcontrib><creatorcontrib>Davide, F.</creatorcontrib><creatorcontrib>Grattarola, M.</creatorcontrib><creatorcontrib>Pasa, S.</creatorcontrib><creatorcontrib>Maura, G.</creatorcontrib><creatorcontrib>Marcoli, M.</creatorcontrib><creatorcontrib>Tedesco, M.B.</creatorcontrib><collection>IEEE Electronic Library (IEL) Conference Proceedings</collection><collection>IEEE Proceedings Order Plan All Online (POP All Online) 1998-present by volume</collection><collection>IEEE Xplore All Conference Proceedings</collection><collection>IEEE Electronic Library (IEL)</collection><collection>IEEE Proceedings Order Plans (POP All) 1998-Present</collection><collection>Pascal-Francis</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Chiappalone, M.</au><au>Davide, F.</au><au>Grattarola, M.</au><au>Pasa, S.</au><au>Maura, G.</au><au>Marcoli, M.</au><au>Tedesco, M.B.</au><format>book</format><genre>proceeding</genre><ristype>CONF</ristype><atitle>Networks of spinal cord neurons cultured on microelectrode arrays: response to stimuli and homeostasis</atitle><btitle>ISPA 2001. Proceedings of the 2nd International Symposium on Image and Signal Processing and Analysis. In conjunction with 23rd International Conference on Information Technology Interfaces (IEEE Cat</btitle><stitle>ISPA</stitle><date>2001</date><risdate>2001</risdate><spage>645</spage><epage>649</epage><pages>645-649</pages><isbn>9539676940</isbn><isbn>9789539676948</isbn><abstract>The use of planar microelectrode arrays allows one to register the electrophysiological activity of cultured neurons under virtual non-invasive conditions for a long period of time (i.e. hours). Several neural networks in the developing central nervous system are spontaneously active and such behavior seems to play an important role in subsequent maturation. Here we show how the bursting electrophysiological activity of cultured spinal cord neurons (15-18 DIV) from the chick embryo is affected by drugs which act on non-NMDA receptors. Interestingly enough, the effects are transient and the network seems to be able to recover its initial spontaneous rhythm. Similar results have been described in the literature in the case of spinal cord explants. Changes in the patterns of electrophysiological activity are described in detail.</abstract><cop>Piscataway NJ</cop><pub>IEEE</pub><doi>10.1109/ISPA.2001.938706</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | ISBN: 9539676940 |
| ispartof | ISPA 2001. Proceedings of the 2nd International Symposium on Image and Signal Processing and Analysis. In conjunction with 23rd International Conference on Information Technology Interfaces (IEEE Cat, 2001, p.645-649 |
| issn | |
| language | eng |
| recordid | cdi_pascalfrancis_primary_14172738 |
| source | IEEE Electronic Library (IEL) Conference Proceedings |
| subjects | Biological and medical sciences Biological neural networks Central nervous system Drugs Electrodes Electrophysiology Embryo Fundamental and applied biological sciences. Psychology In vitro Microelectrodes Neurons Protocols Spinal cord Vertebrates: nervous system and sense organs |
| title | Networks of spinal cord neurons cultured on microelectrode arrays: response to stimuli and homeostasis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-05T07%3A18%3A51IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pascalfrancis_6IE&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=proceeding&rft.atitle=Networks%20of%20spinal%20cord%20neurons%20cultured%20on%20microelectrode%20arrays:%20response%20to%20stimuli%20and%20homeostasis&rft.btitle=ISPA%202001.%20Proceedings%20of%20the%202nd%20International%20Symposium%20on%20Image%20and%20Signal%20Processing%20and%20Analysis.%20In%20conjunction%20with%2023rd%20International%20Conference%20on%20Information%20Technology%20Interfaces%20(IEEE%20Cat&rft.au=Chiappalone,%20M.&rft.date=2001&rft.spage=645&rft.epage=649&rft.pages=645-649&rft.isbn=9539676940&rft.isbn_list=9789539676948&rft_id=info:doi/10.1109/ISPA.2001.938706&rft_dat=%3Cpascalfrancis_6IE%3E14172738%3C/pascalfrancis_6IE%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rft_ieee_id=938706&rfr_iscdi=true |