Duration of feeding on a sucrose-rich diet determines metabolic and morphological changes in rat adipocytes
Department of Biochemistry, University of Litoral, 3000 Santa Fe, Argentina In this work, we studied the effect of a short-term (3 wk) and a long-term (15 wk) administration of a sucrose-rich diet (SRD) to Wistar rats on the morphological aspects and metabolic function of the epididymal adipose tiss...
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| Veröffentlicht in: | Journal of applied physiology (1985) 2001-11, Vol.91 (5), p.2109-2116 |
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| container_title | Journal of applied physiology (1985) |
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| creator | Soria, Ana D'Alessandro, Maria Eugenia Lombardo, Yolanda B |
| description | Department of Biochemistry, University of Litoral, 3000 Santa Fe,
Argentina
In this work, we
studied the effect of a short-term (3 wk) and a long-term (15 wk)
administration of a sucrose-rich diet (SRD) to Wistar rats on the
morphological aspects and metabolic function of the epididymal adipose
tissue that may contribute to the mechanism underlying the impaired
glucose homeostasis and insulin resistance. The present work showed the
following. 1 ) There was both a moderate increase of basal
lipolysis and a decrease of the antilipolytic action of insulin in the
adipocytes of rats fed a SRD for 3 wk. Neither size alterations nor
increases in adipose tissue mass were recorded in this period.
2 ) There was a significant ( P < 0.05)
increase of epididymal weight after 15 wk on a SRD as well as a
hypertrophy of adipocytes with a clear alteration in the cell size
distribution. This was accompanied by a significant increase
( P |
| doi_str_mv | 10.1152/jappl.2001.91.5.2109 |
| format | Article |
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Argentina
In this work, we
studied the effect of a short-term (3 wk) and a long-term (15 wk)
administration of a sucrose-rich diet (SRD) to Wistar rats on the
morphological aspects and metabolic function of the epididymal adipose
tissue that may contribute to the mechanism underlying the impaired
glucose homeostasis and insulin resistance. The present work showed the
following. 1 ) There was both a moderate increase of basal
lipolysis and a decrease of the antilipolytic action of insulin in the
adipocytes of rats fed a SRD for 3 wk. Neither size alterations nor
increases in adipose tissue mass were recorded in this period.
2 ) There was a significant ( P < 0.05)
increase of epididymal weight after 15 wk on a SRD as well as a
hypertrophy of adipocytes with a clear alteration in the cell size
distribution. This was accompanied by a significant increase
( P < 0.05) of basal and stimulated lipolysis and a
marked decrease ( P < 0.05) of the antilipolytic action
of insulin. Moreover, these changes appear together with a worsening of
both impaired glucose homeostasis and insulin resistance. Our results
also indicate that the length of time on the SRD plays an important
role in the evolution of the adiposity and metabolic changes observed in the fat pad. Furthermore, the latter precedes the detection of adiposity.
adipose tissue; dyslipidemia; glucose intolerance; insulin
resistance</description><identifier>ISSN: 8750-7587</identifier><identifier>EISSN: 1522-1601</identifier><identifier>DOI: 10.1152/jappl.2001.91.5.2109</identifier><identifier>PMID: 11641351</identifier><identifier>CODEN: JAPHEV</identifier><language>eng</language><publisher>Bethesda, MD: Am Physiological Soc</publisher><subject>Adipocytes - drug effects ; Adipocytes - metabolism ; Adipocytes - ultrastructure ; Adipose Tissue - drug effects ; Adipose Tissue - physiology ; Animals ; Biological and medical sciences ; Body fat ; Cell Count ; Diet ; Eating ; Feeding. Feeding behavior ; Fundamental and applied biological sciences. Psychology ; Glucose ; Glucose Clamp Technique ; Glycerol - metabolism ; Hyperinsulinism - metabolism ; In Vitro Techniques ; Insulin ; Insulin Resistance - physiology ; Lipoprotein Lipase - metabolism ; Male ; Organ Size - physiology ; Rats ; Rats, Wistar ; Rodents ; Sterol Esterase - metabolism ; Sucrose - pharmacology ; Sugar ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Weight Gain - physiology</subject><ispartof>Journal of applied physiology (1985), 2001-11, Vol.91 (5), p.2109-2116</ispartof><rights>2002 INIST-CNRS</rights><rights>Copyright American Physiological Society Nov 2001</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c504t-69c3dee4b0f2e3a3201b4ca760b59a358eae5ad87f0c80986b3bf040eae4cb783</citedby><cites>FETCH-LOGICAL-c504t-69c3dee4b0f2e3a3201b4ca760b59a358eae5ad87f0c80986b3bf040eae4cb783</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,3040,27926,27927</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14144488$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11641351$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Soria, Ana</creatorcontrib><creatorcontrib>D'Alessandro, Maria Eugenia</creatorcontrib><creatorcontrib>Lombardo, Yolanda B</creatorcontrib><title>Duration of feeding on a sucrose-rich diet determines metabolic and morphological changes in rat adipocytes</title><title>Journal of applied physiology (1985)</title><addtitle>J Appl Physiol (1985)</addtitle><description>Department of Biochemistry, University of Litoral, 3000 Santa Fe,
Argentina
In this work, we
studied the effect of a short-term (3 wk) and a long-term (15 wk)
administration of a sucrose-rich diet (SRD) to Wistar rats on the
morphological aspects and metabolic function of the epididymal adipose
tissue that may contribute to the mechanism underlying the impaired
glucose homeostasis and insulin resistance. The present work showed the
following. 1 ) There was both a moderate increase of basal
lipolysis and a decrease of the antilipolytic action of insulin in the
adipocytes of rats fed a SRD for 3 wk. Neither size alterations nor
increases in adipose tissue mass were recorded in this period.
2 ) There was a significant ( P < 0.05)
increase of epididymal weight after 15 wk on a SRD as well as a
hypertrophy of adipocytes with a clear alteration in the cell size
distribution. This was accompanied by a significant increase
( P < 0.05) of basal and stimulated lipolysis and a
marked decrease ( P < 0.05) of the antilipolytic action
of insulin. Moreover, these changes appear together with a worsening of
both impaired glucose homeostasis and insulin resistance. Our results
also indicate that the length of time on the SRD plays an important
role in the evolution of the adiposity and metabolic changes observed in the fat pad. Furthermore, the latter precedes the detection of adiposity.
adipose tissue; dyslipidemia; glucose intolerance; insulin
resistance</description><subject>Adipocytes - drug effects</subject><subject>Adipocytes - metabolism</subject><subject>Adipocytes - ultrastructure</subject><subject>Adipose Tissue - drug effects</subject><subject>Adipose Tissue - physiology</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Body fat</subject><subject>Cell Count</subject><subject>Diet</subject><subject>Eating</subject><subject>Feeding. Feeding behavior</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glucose</subject><subject>Glucose Clamp Technique</subject><subject>Glycerol - metabolism</subject><subject>Hyperinsulinism - metabolism</subject><subject>In Vitro Techniques</subject><subject>Insulin</subject><subject>Insulin Resistance - physiology</subject><subject>Lipoprotein Lipase - metabolism</subject><subject>Male</subject><subject>Organ Size - physiology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Rodents</subject><subject>Sterol Esterase - metabolism</subject><subject>Sucrose - pharmacology</subject><subject>Sugar</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>Weight Gain - physiology</subject><issn>8750-7587</issn><issn>1522-1601</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kVGP1CAUhYnRuLOr_8AYYuLGl1ag0NJHs7pqsokv6zOh9DJlpKVCG51_L3UnjjHxicD9zr2XcxB6QUlJqWBvD3qefckIoWVLS1EyStpHaJdLrKA1oY_RTjaCFI2QzQW6TOmQUc4FfYouKK05rQTdoW_v16gXFyYcLLYAvZv2ON80TquJIUERnRlw72DBPSwQRzdBwiMsugveGaynHo8hzkPwYe-M9tgMetpnxk04t8a6d3MwxwXSM_TEap_g-em8Ql9vP9zffCruvnz8fPPurjCC8KWoW1P1ALwjlkGlK0Zox41uatKJVldCggahe9lYYiRpZd1VnSWc5GduukZWV-j6oe8cw_cV0qJGlwx4rycIa1INY9v_RQZf_QMewhqnvJtimeGS8zpD_AHa7EgRrJqjG3U8KkrUloT6nYTaklAtVUJtSWTZy1PvtRuhP4tO1mfg9QnQKdtmo56MS2eO57C4lOf5g9sPP1wENQ_H5Da7j-p29f4efi7bDn9mq7m3Wfbm_7JM_7XqL9sotPg</recordid><startdate>200111</startdate><enddate>200111</enddate><creator>Soria, Ana</creator><creator>D'Alessandro, Maria Eugenia</creator><creator>Lombardo, Yolanda B</creator><general>Am Physiological Soc</general><general>American Physiological Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7TS</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>200111</creationdate><title>Duration of feeding on a sucrose-rich diet determines metabolic and morphological changes in rat adipocytes</title><author>Soria, Ana ; D'Alessandro, Maria Eugenia ; Lombardo, Yolanda B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c504t-69c3dee4b0f2e3a3201b4ca760b59a358eae5ad87f0c80986b3bf040eae4cb783</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adipocytes - drug effects</topic><topic>Adipocytes - metabolism</topic><topic>Adipocytes - ultrastructure</topic><topic>Adipose Tissue - drug effects</topic><topic>Adipose Tissue - physiology</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Body fat</topic><topic>Cell Count</topic><topic>Diet</topic><topic>Eating</topic><topic>Feeding. Feeding behavior</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Glucose</topic><topic>Glucose Clamp Technique</topic><topic>Glycerol - metabolism</topic><topic>Hyperinsulinism - metabolism</topic><topic>In Vitro Techniques</topic><topic>Insulin</topic><topic>Insulin Resistance - physiology</topic><topic>Lipoprotein Lipase - metabolism</topic><topic>Male</topic><topic>Organ Size - physiology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Rodents</topic><topic>Sterol Esterase - metabolism</topic><topic>Sucrose - pharmacology</topic><topic>Sugar</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>Weight Gain - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Soria, Ana</creatorcontrib><creatorcontrib>D'Alessandro, Maria Eugenia</creatorcontrib><creatorcontrib>Lombardo, Yolanda B</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of applied physiology (1985)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Soria, Ana</au><au>D'Alessandro, Maria Eugenia</au><au>Lombardo, Yolanda B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Duration of feeding on a sucrose-rich diet determines metabolic and morphological changes in rat adipocytes</atitle><jtitle>Journal of applied physiology (1985)</jtitle><addtitle>J Appl Physiol (1985)</addtitle><date>2001-11</date><risdate>2001</risdate><volume>91</volume><issue>5</issue><spage>2109</spage><epage>2116</epage><pages>2109-2116</pages><issn>8750-7587</issn><eissn>1522-1601</eissn><coden>JAPHEV</coden><abstract>Department of Biochemistry, University of Litoral, 3000 Santa Fe,
Argentina
In this work, we
studied the effect of a short-term (3 wk) and a long-term (15 wk)
administration of a sucrose-rich diet (SRD) to Wistar rats on the
morphological aspects and metabolic function of the epididymal adipose
tissue that may contribute to the mechanism underlying the impaired
glucose homeostasis and insulin resistance. The present work showed the
following. 1 ) There was both a moderate increase of basal
lipolysis and a decrease of the antilipolytic action of insulin in the
adipocytes of rats fed a SRD for 3 wk. Neither size alterations nor
increases in adipose tissue mass were recorded in this period.
2 ) There was a significant ( P < 0.05)
increase of epididymal weight after 15 wk on a SRD as well as a
hypertrophy of adipocytes with a clear alteration in the cell size
distribution. This was accompanied by a significant increase
( P < 0.05) of basal and stimulated lipolysis and a
marked decrease ( P < 0.05) of the antilipolytic action
of insulin. Moreover, these changes appear together with a worsening of
both impaired glucose homeostasis and insulin resistance. Our results
also indicate that the length of time on the SRD plays an important
role in the evolution of the adiposity and metabolic changes observed in the fat pad. Furthermore, the latter precedes the detection of adiposity.
adipose tissue; dyslipidemia; glucose intolerance; insulin
resistance</abstract><cop>Bethesda, MD</cop><pub>Am Physiological Soc</pub><pmid>11641351</pmid><doi>10.1152/jappl.2001.91.5.2109</doi><tpages>8</tpages></addata></record> |
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| ispartof | Journal of applied physiology (1985), 2001-11, Vol.91 (5), p.2109-2116 |
| issn | 8750-7587 1522-1601 |
| language | eng |
| recordid | cdi_pascalfrancis_primary_14144488 |
| source | MEDLINE; American Physiological Society; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adipocytes - drug effects Adipocytes - metabolism Adipocytes - ultrastructure Adipose Tissue - drug effects Adipose Tissue - physiology Animals Biological and medical sciences Body fat Cell Count Diet Eating Feeding. Feeding behavior Fundamental and applied biological sciences. Psychology Glucose Glucose Clamp Technique Glycerol - metabolism Hyperinsulinism - metabolism In Vitro Techniques Insulin Insulin Resistance - physiology Lipoprotein Lipase - metabolism Male Organ Size - physiology Rats Rats, Wistar Rodents Sterol Esterase - metabolism Sucrose - pharmacology Sugar Vertebrates: anatomy and physiology, studies on body, several organs or systems Weight Gain - physiology |
| title | Duration of feeding on a sucrose-rich diet determines metabolic and morphological changes in rat adipocytes |
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