Substrate spectrum of mandelate racemase: Part 2. (Hetero)-aryl-substituted mandelate derivatives and modulation of activity

Efficient enzymatic racemization of 2-hydroxy-2-heteroaryl-acetic acid derivatives by mandelate racemase under mild conditions is reported for the first time. (i) Steric limitations for aryl-substituted mandelate derivatives were elucidated to be particularly striking for o-substituents, whereas m-...

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Veröffentlicht in:	Journal of molecular catalysis. B, Enzymatic Enzymatic, 2001-11, Vol.15 (4), p.213-222
Hauptverfasser:	Felfer, Ulfried, Strauss, Ulrike T., Kroutil, Wolfgang, Fabian, Walter M.F., Faber, Kurt
Format:	Artikel
Sprache:	eng
Schlagworte:	Bioconversions. Hemisynthesis Biological and medical sciences Biotechnology Enzymatic racemization Fundamental and applied biological sciences. Psychology Mandelate racemase [EC 5.1.2.2] Mandelic acid Methods. Procedures. Technologies Pseudomonas putida ATCC 12633 α-Hydroxy heteroarylacetic acid
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