Sarcoplasmic Reticulum Ca2+ ATPase (SERCA) 1a Structurally Substitutes for SERCA2a in the Cardiac Sarcoplasmic Reticulum and Increases Cardiac Ca2+ Handling Capacity

ABSTRACT—Ectopic expression of the sarcoplasmic reticulum (SR) Ca ATPase (SERCA) 1a pump in the mouse heart results in a 2.5-fold increase in total SERCA pump level. SERCA1a hearts show increased rates of contraction/relaxation and enhanced Ca transients; however, the cellular mechanisms underlying...

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Veröffentlicht in:	Circulation research 2001-07, Vol.89 (2), p.160-167
Hauptverfasser:	Jane Lalli, M, Yong, Ji, Prasad, Vikram, Hashimoto, Katsuji, Plank, Dave, Babu, Gopal J, Kirkpatrick, Darryl, Walsh, Richard A, Sussman, Mark, Yatani, Atsuko, Marbán, Eduardo, Periasamy, Muthu
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Biotechnology Fundamental and applied biological sciences. Psychology Gene therapy Health. Pharmaceutical industry Heart Industrial applications and implications. Economical aspects Vertebrates: cardiovascular system
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