1,2-Benzothiazine 1,1-Dioxide P2−P3 Peptide Mimetic Aldehyde Calpain I Inhibitors

A series of peptide mimetic aldehyde inhibitors of calpain I was prepared in which the P2 and P3 amino acids were replaced by substituted 3,4-dihydro-1,2-benzothiazine-3-carboxylate 1,1-dioxides. The effect of 2, 6, and 7-benzothiazine substituents and the P1 amino acid was examined. Potency of thes...

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Veröffentlicht in:	Journal of medicinal chemistry 2001-10, Vol.44 (21), p.3488-3503
Hauptverfasser:	Wells, Gregory J, Tao, Ming, Josef, Kurt A, Bihovsky, Ron
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Medical sciences Neuropharmacology Neuroprotective agent Pharmacology. Drug treatments
Online-Zugang:	Volltext
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