Effect of position, nitric oxide, and almitrine on lung perfusion in a porcine model of acute lung injury
Service de Réanimation Médicale et Assistance Respiratoire, Lyon 69004; Equipe d'Accueil Universitaire 1896, Université Claude Bernard Lyon I, 69008 Lyon; Centre d'Exploration et de Recherche Médicales par Emission de Positons, Hôpital Neuro-Cardiologique, 69003 Lyon, France In a porcine m...
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| Veröffentlicht in: | Journal of applied physiology (1985) 2002-12, Vol.93 (6), p.2181-2191 |
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| container_title | Journal of applied physiology (1985) |
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| creator | Richard, J. C Janier, M Lavenne, F Berthier, V Lebars, D Annat, G Decailliot, F Guerin, C |
| description | Service de Réanimation Médicale et Assistance
Respiratoire, Lyon 69004; Equipe d'Accueil Universitaire 1896, Université Claude Bernard Lyon I, 69008 Lyon; Centre
d'Exploration et de Recherche Médicales par Emission de
Positons, Hôpital Neuro-Cardiologique, 69003 Lyon,
France
In a porcine model of
oleic acid-induced lung injury, the effects of inhaled nitric oxide
(iNO) and intravenous almitrine bismesylate (ivALM), which enhances
the hypoxic pulmonary vasoconstriction on the distribution of regional
pulmonary blood flow (PBF), were assessed. After injection of 0.12 ml/kg oleic acid, 20 anesthetized and mechanically ventilated piglets
[weight of 25 ± 2.6 (SD) kg] were randomly divided into four
groups: supine position, prone position, and 10 ppm iNO for 40 min
followed by 4 µg · kg 1 · min 1
ivALM for 40 min in supine position and in prone position. PBF was
measured with positron emission tomography and
H 2 15 O. The redistribution of PBF was studied on
a pixel-by-pixel basis. Positron emission tomography scans were
performed before and then 120, 160, and 200 min after injury. With
prone position alone, although PBF remained prevalent in the dorsal
regions it was significantly redistributed toward the ventral
regions ( P |
| doi_str_mv | 10.1152/japplphysiol.00313.2002 |
| format | Article |
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Respiratoire, Lyon 69004; Equipe d'Accueil Universitaire 1896, Université Claude Bernard Lyon I, 69008 Lyon; Centre
d'Exploration et de Recherche Médicales par Emission de
Positons, Hôpital Neuro-Cardiologique, 69003 Lyon,
France
In a porcine model of
oleic acid-induced lung injury, the effects of inhaled nitric oxide
(iNO) and intravenous almitrine bismesylate (ivALM), which enhances
the hypoxic pulmonary vasoconstriction on the distribution of regional
pulmonary blood flow (PBF), were assessed. After injection of 0.12 ml/kg oleic acid, 20 anesthetized and mechanically ventilated piglets
[weight of 25 ± 2.6 (SD) kg] were randomly divided into four
groups: supine position, prone position, and 10 ppm iNO for 40 min
followed by 4 µg · kg 1 · min 1
ivALM for 40 min in supine position and in prone position. PBF was
measured with positron emission tomography and
H 2 15 O. The redistribution of PBF was studied on
a pixel-by-pixel basis. Positron emission tomography scans were
performed before and then 120, 160, and 200 min after injury. With
prone position alone, although PBF remained prevalent in the dorsal
regions it was significantly redistributed toward the ventral
regions ( P < 0.001). A ventral redistribution of PBF
was also obtained with iNO regardless of the position
( P = 0.043). Adjunction of ivALM had no further effect on PBF redistribution. PP and iNO have an additive effect on ventral redistribution of PBF.
prone position; oleic acid; pulmonary blood flow; positron emission
tomography; inhaled nitric oxide</description><identifier>ISSN: 8750-7587</identifier><identifier>EISSN: 1522-1601</identifier><identifier>DOI: 10.1152/japplphysiol.00313.2002</identifier><identifier>PMID: 12391113</identifier><identifier>CODEN: JAPHEV</identifier><language>eng</language><publisher>Bethesda, MD: Am Physiological Soc</publisher><subject>Acute Disease ; Administration, Inhalation ; Almitrine - pharmacology ; Animals ; Biological and medical sciences ; Disease Models, Animal ; Injuries ; Lung Diseases - diagnostic imaging ; Lung Diseases - physiopathology ; Male ; Medical sciences ; Nitric oxide ; Nitric Oxide - pharmacology ; Oleic Acid - pharmacology ; Pneumology ; Prone Position ; Pulmonary Circulation - drug effects ; Pulmonary Circulation - physiology ; Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases ; Respiratory diseases ; Respiratory Mechanics - drug effects ; Respiratory Mechanics - physiology ; Respiratory System Agents - pharmacology ; Supine Position ; Swine ; Tomography, Emission-Computed</subject><ispartof>Journal of applied physiology (1985), 2002-12, Vol.93 (6), p.2181-2191</ispartof><rights>2003 INIST-CNRS</rights><rights>Copyright American Physiological Society Dec 2002</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c444t-a48b2c26a3b9c1aa5bf645be533fc97c4dc5ab462bc94a0f69cc5086232eb5a03</citedby><cites>FETCH-LOGICAL-c444t-a48b2c26a3b9c1aa5bf645be533fc97c4dc5ab462bc94a0f69cc5086232eb5a03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,3039,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14034450$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12391113$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Richard, J. C</creatorcontrib><creatorcontrib>Janier, M</creatorcontrib><creatorcontrib>Lavenne, F</creatorcontrib><creatorcontrib>Berthier, V</creatorcontrib><creatorcontrib>Lebars, D</creatorcontrib><creatorcontrib>Annat, G</creatorcontrib><creatorcontrib>Decailliot, F</creatorcontrib><creatorcontrib>Guerin, C</creatorcontrib><title>Effect of position, nitric oxide, and almitrine on lung perfusion in a porcine model of acute lung injury</title><title>Journal of applied physiology (1985)</title><addtitle>J Appl Physiol (1985)</addtitle><description>Service de Réanimation Médicale et Assistance
Respiratoire, Lyon 69004; Equipe d'Accueil Universitaire 1896, Université Claude Bernard Lyon I, 69008 Lyon; Centre
d'Exploration et de Recherche Médicales par Emission de
Positons, Hôpital Neuro-Cardiologique, 69003 Lyon,
France
In a porcine model of
oleic acid-induced lung injury, the effects of inhaled nitric oxide
(iNO) and intravenous almitrine bismesylate (ivALM), which enhances
the hypoxic pulmonary vasoconstriction on the distribution of regional
pulmonary blood flow (PBF), were assessed. After injection of 0.12 ml/kg oleic acid, 20 anesthetized and mechanically ventilated piglets
[weight of 25 ± 2.6 (SD) kg] were randomly divided into four
groups: supine position, prone position, and 10 ppm iNO for 40 min
followed by 4 µg · kg 1 · min 1
ivALM for 40 min in supine position and in prone position. PBF was
measured with positron emission tomography and
H 2 15 O. The redistribution of PBF was studied on
a pixel-by-pixel basis. Positron emission tomography scans were
performed before and then 120, 160, and 200 min after injury. With
prone position alone, although PBF remained prevalent in the dorsal
regions it was significantly redistributed toward the ventral
regions ( P < 0.001). A ventral redistribution of PBF
was also obtained with iNO regardless of the position
( P = 0.043). Adjunction of ivALM had no further effect on PBF redistribution. PP and iNO have an additive effect on ventral redistribution of PBF.
prone position; oleic acid; pulmonary blood flow; positron emission
tomography; inhaled nitric oxide</description><subject>Acute Disease</subject><subject>Administration, Inhalation</subject><subject>Almitrine - pharmacology</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Disease Models, Animal</subject><subject>Injuries</subject><subject>Lung Diseases - diagnostic imaging</subject><subject>Lung Diseases - physiopathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nitric oxide</subject><subject>Nitric Oxide - pharmacology</subject><subject>Oleic Acid - pharmacology</subject><subject>Pneumology</subject><subject>Prone Position</subject><subject>Pulmonary Circulation - drug effects</subject><subject>Pulmonary Circulation - physiology</subject><subject>Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases</subject><subject>Respiratory diseases</subject><subject>Respiratory Mechanics - drug effects</subject><subject>Respiratory Mechanics - physiology</subject><subject>Respiratory System Agents - pharmacology</subject><subject>Supine Position</subject><subject>Swine</subject><subject>Tomography, Emission-Computed</subject><issn>8750-7587</issn><issn>1522-1601</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kV1vFCEYhYnR2LX1Lygx0XjRWfmcj0vTtNqkiTftNWEY2GXDwAhD7P57GXdijUm5IeF9zjnAAeA9RluMOflykNPkpv0x2eC2CFFMtwQh8gJsypRUuEb4Jdi0DUdVw9vmDLxJ6YAQZozj1-AME9phjOkG2GtjtJphMHAKyc42-Evo7RytguHRDvoSSj9A6cblzGsYPHTZ7-Cko8kl3kProSziqJbxGAbtFjep8qxPqPWHHI8X4JWRLum3634OHm6u76--V3c_vt1efb2rFGNsriRre6JILWnfKSwl703NeK85pUZ1jWKD4rJnNelVxyQydacUR21NKNE9l4ieg08n3ymGn1mnWYw2Ke2c9DrkJBpSN5wjUsAP_4GHkKMvdxOkLMx50xSoOUEqhpSiNmKKdpTxKDASSxXi3yrEnyrEUkVRvlvtcz_q4Um3_n0BPq6ATEo6E6VXNj1xDNFS1_Kgzydub3f7XzZqsaaF3XFJFx0VtSC4xQVlz6M32bl7_Tgvmr8SMQ2G_gaYrbd6</recordid><startdate>20021201</startdate><enddate>20021201</enddate><creator>Richard, J. C</creator><creator>Janier, M</creator><creator>Lavenne, F</creator><creator>Berthier, V</creator><creator>Lebars, D</creator><creator>Annat, G</creator><creator>Decailliot, F</creator><creator>Guerin, C</creator><general>Am Physiological Soc</general><general>American Physiological Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7TS</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20021201</creationdate><title>Effect of position, nitric oxide, and almitrine on lung perfusion in a porcine model of acute lung injury</title><author>Richard, J. C ; Janier, M ; Lavenne, F ; Berthier, V ; Lebars, D ; Annat, G ; Decailliot, F ; Guerin, C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c444t-a48b2c26a3b9c1aa5bf645be533fc97c4dc5ab462bc94a0f69cc5086232eb5a03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Acute Disease</topic><topic>Administration, Inhalation</topic><topic>Almitrine - pharmacology</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Disease Models, Animal</topic><topic>Injuries</topic><topic>Lung Diseases - diagnostic imaging</topic><topic>Lung Diseases - physiopathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Nitric oxide</topic><topic>Nitric Oxide - pharmacology</topic><topic>Oleic Acid - pharmacology</topic><topic>Pneumology</topic><topic>Prone Position</topic><topic>Pulmonary Circulation - drug effects</topic><topic>Pulmonary Circulation - physiology</topic><topic>Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases</topic><topic>Respiratory diseases</topic><topic>Respiratory Mechanics - drug effects</topic><topic>Respiratory Mechanics - physiology</topic><topic>Respiratory System Agents - pharmacology</topic><topic>Supine Position</topic><topic>Swine</topic><topic>Tomography, Emission-Computed</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Richard, J. C</creatorcontrib><creatorcontrib>Janier, M</creatorcontrib><creatorcontrib>Lavenne, F</creatorcontrib><creatorcontrib>Berthier, V</creatorcontrib><creatorcontrib>Lebars, D</creatorcontrib><creatorcontrib>Annat, G</creatorcontrib><creatorcontrib>Decailliot, F</creatorcontrib><creatorcontrib>Guerin, C</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of applied physiology (1985)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Richard, J. C</au><au>Janier, M</au><au>Lavenne, F</au><au>Berthier, V</au><au>Lebars, D</au><au>Annat, G</au><au>Decailliot, F</au><au>Guerin, C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of position, nitric oxide, and almitrine on lung perfusion in a porcine model of acute lung injury</atitle><jtitle>Journal of applied physiology (1985)</jtitle><addtitle>J Appl Physiol (1985)</addtitle><date>2002-12-01</date><risdate>2002</risdate><volume>93</volume><issue>6</issue><spage>2181</spage><epage>2191</epage><pages>2181-2191</pages><issn>8750-7587</issn><eissn>1522-1601</eissn><coden>JAPHEV</coden><abstract>Service de Réanimation Médicale et Assistance
Respiratoire, Lyon 69004; Equipe d'Accueil Universitaire 1896, Université Claude Bernard Lyon I, 69008 Lyon; Centre
d'Exploration et de Recherche Médicales par Emission de
Positons, Hôpital Neuro-Cardiologique, 69003 Lyon,
France
In a porcine model of
oleic acid-induced lung injury, the effects of inhaled nitric oxide
(iNO) and intravenous almitrine bismesylate (ivALM), which enhances
the hypoxic pulmonary vasoconstriction on the distribution of regional
pulmonary blood flow (PBF), were assessed. After injection of 0.12 ml/kg oleic acid, 20 anesthetized and mechanically ventilated piglets
[weight of 25 ± 2.6 (SD) kg] were randomly divided into four
groups: supine position, prone position, and 10 ppm iNO for 40 min
followed by 4 µg · kg 1 · min 1
ivALM for 40 min in supine position and in prone position. PBF was
measured with positron emission tomography and
H 2 15 O. The redistribution of PBF was studied on
a pixel-by-pixel basis. Positron emission tomography scans were
performed before and then 120, 160, and 200 min after injury. With
prone position alone, although PBF remained prevalent in the dorsal
regions it was significantly redistributed toward the ventral
regions ( P < 0.001). A ventral redistribution of PBF
was also obtained with iNO regardless of the position
( P = 0.043). Adjunction of ivALM had no further effect on PBF redistribution. PP and iNO have an additive effect on ventral redistribution of PBF.
prone position; oleic acid; pulmonary blood flow; positron emission
tomography; inhaled nitric oxide</abstract><cop>Bethesda, MD</cop><pub>Am Physiological Soc</pub><pmid>12391113</pmid><doi>10.1152/japplphysiol.00313.2002</doi><tpages>11</tpages></addata></record> |
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| ispartof | Journal of applied physiology (1985), 2002-12, Vol.93 (6), p.2181-2191 |
| issn | 8750-7587 1522-1601 |
| language | eng |
| recordid | cdi_pascalfrancis_primary_14034450 |
| source | MEDLINE; American Physiological Society; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Acute Disease Administration, Inhalation Almitrine - pharmacology Animals Biological and medical sciences Disease Models, Animal Injuries Lung Diseases - diagnostic imaging Lung Diseases - physiopathology Male Medical sciences Nitric oxide Nitric Oxide - pharmacology Oleic Acid - pharmacology Pneumology Prone Position Pulmonary Circulation - drug effects Pulmonary Circulation - physiology Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases Respiratory diseases Respiratory Mechanics - drug effects Respiratory Mechanics - physiology Respiratory System Agents - pharmacology Supine Position Swine Tomography, Emission-Computed |
| title | Effect of position, nitric oxide, and almitrine on lung perfusion in a porcine model of acute lung injury |
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