Bradykinin does not mediate cutaneous active vasodilation during heat stress in humans
1 Geriatric Research, Education, and Clinical Center, Department of Veterans Affairs, South Texas Veterans Health Care System, Audie L. Murphy Memorial Veterans Hospital Division, and Divisions of 2 Geriatrics and Gerontology and 3 Nephrology, Department of Medicine, University of Texas Health Sc...
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| Veröffentlicht in: | Journal of applied physiology (1985) 2002-10, Vol.93 (4), p.1215-1221 |
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| container_title | Journal of applied physiology (1985) |
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| creator | Kellogg, D. L., Jr Liu, Y McAllister, K Friel, C Pergola, P. E |
| description | 1 Geriatric Research, Education, and Clinical
Center, Department of Veterans Affairs, South Texas Veterans Health
Care System, Audie L. Murphy Memorial Veterans Hospital Division,
and Divisions of 2 Geriatrics and Gerontology and
3 Nephrology, Department of Medicine, University of
Texas Health Science Center at San Antonio, San Antonio, Texas 78229
To test
the hypothesis that bradykinin effects cutaneous active vasodilation
during hyperthermia, we examined whether the increase in skin blood
flow (SkBF) during heat stress was affected by blockade of bradykinin
B 2 receptors with the receptor antagonist HOE-140.
Two adjacent sites on the forearm were instrumented with intradermal
microdialysis probes for local delivery of drugs in eight healthy
subjects. HOE-140 was dissolved in Ringer solution (40 µM) and
perfused at one site, whereas the second site was perfused with Ringer
alone. SkBF was monitored by laser-Doppler flowmetry (LDF) at
both sites. Mean arterial pressure (MAP) was monitored from a finger,
and cutaneous vascular conductance (CVC) was calculated (CVC = LDF/MAP). Water-perfused suits were used to control body temperature
and evoke hyperthermia. After hyperthermia, both microdialysis sites
were perfused with 28 mM nitroprusside to effect maximal vasodilation.
During hyperthermia, CVC increased at HOE-140 (69 ± 2% maximal
CVC, P |
| doi_str_mv | 10.1152/japplphysiol.01142.2001 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pasca</sourceid><recordid>TN_cdi_pascalfrancis_primary_13934299</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>72102546</sourcerecordid><originalsourceid>FETCH-LOGICAL-c444t-29f5f5d1b45a12b61f754b18559c9c480bbec1bb855b4272d953697cd6a5ab833</originalsourceid><addsrcrecordid>eNp1kF2L1DAUhoMo7jj6F7QIijcdc_LRTC7XxVVhwZvV25Ck6TRjp6lJujr_3oxTXBG8Cpw873sOD0IvAG8AOHm719M0TP0x-TBsMAAjG4IxPECr8ktqaDA8RKut4LgWfCsu0JOU9gVgjMNjdAGEUI5BrNDXd1G3x29-9GPVBpeqMeTq4Fqvs6vsnPXowpwqbbO_c9WdTqH1g84-FHyOftxVvdO5Sjm6lKpS0s8HPaan6FGnh-SeLe8afbl-f3v1sb75_OHT1eVNbRljuSay4x1vwTCugZgGOsGZgS3n0krLttgYZ8GYMjCMCNJKThspbNtors2W0jV6fe6dYvg-u5TVwSfrhuF8txIEMOGsKeDLf8B9mONYblOEEOCUSlEgcYZsDClF16kp-oOORwVYnbyrv72r397VyXtJPl_qZ1Ps3ecW0QV4tQA6WT10UY_Wp3uOSsqIlIV7c-Z6v-t_-OjUsi3sjqftSlLFSm25eI3Y_9HreRhu3c98yvyJqKnt6C9zEbDc</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>222153397</pqid></control><display><type>article</type><title>Bradykinin does not mediate cutaneous active vasodilation during heat stress in humans</title><source>MEDLINE</source><source>American Physiological Society</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>Kellogg, D. L., Jr ; Liu, Y ; McAllister, K ; Friel, C ; Pergola, P. E</creator><creatorcontrib>Kellogg, D. L., Jr ; Liu, Y ; McAllister, K ; Friel, C ; Pergola, P. E</creatorcontrib><description>1 Geriatric Research, Education, and Clinical
Center, Department of Veterans Affairs, South Texas Veterans Health
Care System, Audie L. Murphy Memorial Veterans Hospital Division,
and Divisions of 2 Geriatrics and Gerontology and
3 Nephrology, Department of Medicine, University of
Texas Health Science Center at San Antonio, San Antonio, Texas 78229
To test
the hypothesis that bradykinin effects cutaneous active vasodilation
during hyperthermia, we examined whether the increase in skin blood
flow (SkBF) during heat stress was affected by blockade of bradykinin
B 2 receptors with the receptor antagonist HOE-140.
Two adjacent sites on the forearm were instrumented with intradermal
microdialysis probes for local delivery of drugs in eight healthy
subjects. HOE-140 was dissolved in Ringer solution (40 µM) and
perfused at one site, whereas the second site was perfused with Ringer
alone. SkBF was monitored by laser-Doppler flowmetry (LDF) at
both sites. Mean arterial pressure (MAP) was monitored from a finger,
and cutaneous vascular conductance (CVC) was calculated (CVC = LDF/MAP). Water-perfused suits were used to control body temperature
and evoke hyperthermia. After hyperthermia, both microdialysis sites
were perfused with 28 mM nitroprusside to effect maximal vasodilation.
During hyperthermia, CVC increased at HOE-140 (69 ± 2% maximal
CVC, P < 0.01) and untreated sites (65 ± 2%
maximal CVC, P < 0.01). These responses did not differ between sites ( P > 0.05). Because the bradykinin
B 2 -receptor antagonist HOE-140 did not alter SkBF responses
to heat stress, we conclude that bradykinin does not mediate cutaneous
active vasodilation.
microdialysis; laser-Doppler flowmetry</description><identifier>ISSN: 8750-7587</identifier><identifier>EISSN: 1522-1601</identifier><identifier>DOI: 10.1152/japplphysiol.01142.2001</identifier><identifier>PMID: 12235017</identifier><identifier>CODEN: JAPHEV</identifier><language>eng</language><publisher>Bethesda, MD: Am Physiological Soc</publisher><subject>Adult ; Biological and medical sciences ; Body fluids ; Bradykinin - analogs & derivatives ; Bradykinin - metabolism ; Bradykinin - pharmacology ; Bradykinin Receptor Antagonists ; Endocrine system ; Female ; Forearm ; Fundamental and applied biological sciences. Psychology ; Heat ; Hot Temperature ; Humans ; Laser-Doppler Flowmetry ; Male ; Microdialysis ; Peptides ; Receptor, Bradykinin B2 ; Skin ; Skin - blood supply ; Stress, Physiological - physiopathology ; Thermoregulation. Hibernation. Estivation. Ecophysiology and environmental effects ; Vasodilation - drug effects ; Vasodilation - physiology ; Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><ispartof>Journal of applied physiology (1985), 2002-10, Vol.93 (4), p.1215-1221</ispartof><rights>2003 INIST-CNRS</rights><rights>Copyright American Physiological Society Oct 2002</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c444t-29f5f5d1b45a12b61f754b18559c9c480bbec1bb855b4272d953697cd6a5ab833</citedby><cites>FETCH-LOGICAL-c444t-29f5f5d1b45a12b61f754b18559c9c480bbec1bb855b4272d953697cd6a5ab833</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3026,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13934299$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12235017$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kellogg, D. L., Jr</creatorcontrib><creatorcontrib>Liu, Y</creatorcontrib><creatorcontrib>McAllister, K</creatorcontrib><creatorcontrib>Friel, C</creatorcontrib><creatorcontrib>Pergola, P. E</creatorcontrib><title>Bradykinin does not mediate cutaneous active vasodilation during heat stress in humans</title><title>Journal of applied physiology (1985)</title><addtitle>J Appl Physiol (1985)</addtitle><description>1 Geriatric Research, Education, and Clinical
Center, Department of Veterans Affairs, South Texas Veterans Health
Care System, Audie L. Murphy Memorial Veterans Hospital Division,
and Divisions of 2 Geriatrics and Gerontology and
3 Nephrology, Department of Medicine, University of
Texas Health Science Center at San Antonio, San Antonio, Texas 78229
To test
the hypothesis that bradykinin effects cutaneous active vasodilation
during hyperthermia, we examined whether the increase in skin blood
flow (SkBF) during heat stress was affected by blockade of bradykinin
B 2 receptors with the receptor antagonist HOE-140.
Two adjacent sites on the forearm were instrumented with intradermal
microdialysis probes for local delivery of drugs in eight healthy
subjects. HOE-140 was dissolved in Ringer solution (40 µM) and
perfused at one site, whereas the second site was perfused with Ringer
alone. SkBF was monitored by laser-Doppler flowmetry (LDF) at
both sites. Mean arterial pressure (MAP) was monitored from a finger,
and cutaneous vascular conductance (CVC) was calculated (CVC = LDF/MAP). Water-perfused suits were used to control body temperature
and evoke hyperthermia. After hyperthermia, both microdialysis sites
were perfused with 28 mM nitroprusside to effect maximal vasodilation.
During hyperthermia, CVC increased at HOE-140 (69 ± 2% maximal
CVC, P < 0.01) and untreated sites (65 ± 2%
maximal CVC, P < 0.01). These responses did not differ between sites ( P > 0.05). Because the bradykinin
B 2 -receptor antagonist HOE-140 did not alter SkBF responses
to heat stress, we conclude that bradykinin does not mediate cutaneous
active vasodilation.
microdialysis; laser-Doppler flowmetry</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Body fluids</subject><subject>Bradykinin - analogs & derivatives</subject><subject>Bradykinin - metabolism</subject><subject>Bradykinin - pharmacology</subject><subject>Bradykinin Receptor Antagonists</subject><subject>Endocrine system</subject><subject>Female</subject><subject>Forearm</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Heat</subject><subject>Hot Temperature</subject><subject>Humans</subject><subject>Laser-Doppler Flowmetry</subject><subject>Male</subject><subject>Microdialysis</subject><subject>Peptides</subject><subject>Receptor, Bradykinin B2</subject><subject>Skin</subject><subject>Skin - blood supply</subject><subject>Stress, Physiological - physiopathology</subject><subject>Thermoregulation. Hibernation. Estivation. Ecophysiology and environmental effects</subject><subject>Vasodilation - drug effects</subject><subject>Vasodilation - physiology</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><issn>8750-7587</issn><issn>1522-1601</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kF2L1DAUhoMo7jj6F7QIijcdc_LRTC7XxVVhwZvV25Ck6TRjp6lJujr_3oxTXBG8Cpw873sOD0IvAG8AOHm719M0TP0x-TBsMAAjG4IxPECr8ktqaDA8RKut4LgWfCsu0JOU9gVgjMNjdAGEUI5BrNDXd1G3x29-9GPVBpeqMeTq4Fqvs6vsnPXowpwqbbO_c9WdTqH1g84-FHyOftxVvdO5Sjm6lKpS0s8HPaan6FGnh-SeLe8afbl-f3v1sb75_OHT1eVNbRljuSay4x1vwTCugZgGOsGZgS3n0krLttgYZ8GYMjCMCNJKThspbNtors2W0jV6fe6dYvg-u5TVwSfrhuF8txIEMOGsKeDLf8B9mONYblOEEOCUSlEgcYZsDClF16kp-oOORwVYnbyrv72r397VyXtJPl_qZ1Ps3ecW0QV4tQA6WT10UY_Wp3uOSsqIlIV7c-Z6v-t_-OjUsi3sjqftSlLFSm25eI3Y_9HreRhu3c98yvyJqKnt6C9zEbDc</recordid><startdate>20021001</startdate><enddate>20021001</enddate><creator>Kellogg, D. L., Jr</creator><creator>Liu, Y</creator><creator>McAllister, K</creator><creator>Friel, C</creator><creator>Pergola, P. E</creator><general>Am Physiological Soc</general><general>American Physiological Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7TS</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20021001</creationdate><title>Bradykinin does not mediate cutaneous active vasodilation during heat stress in humans</title><author>Kellogg, D. L., Jr ; Liu, Y ; McAllister, K ; Friel, C ; Pergola, P. E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c444t-29f5f5d1b45a12b61f754b18559c9c480bbec1bb855b4272d953697cd6a5ab833</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Body fluids</topic><topic>Bradykinin - analogs & derivatives</topic><topic>Bradykinin - metabolism</topic><topic>Bradykinin - pharmacology</topic><topic>Bradykinin Receptor Antagonists</topic><topic>Endocrine system</topic><topic>Female</topic><topic>Forearm</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Heat</topic><topic>Hot Temperature</topic><topic>Humans</topic><topic>Laser-Doppler Flowmetry</topic><topic>Male</topic><topic>Microdialysis</topic><topic>Peptides</topic><topic>Receptor, Bradykinin B2</topic><topic>Skin</topic><topic>Skin - blood supply</topic><topic>Stress, Physiological - physiopathology</topic><topic>Thermoregulation. Hibernation. Estivation. Ecophysiology and environmental effects</topic><topic>Vasodilation - drug effects</topic><topic>Vasodilation - physiology</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kellogg, D. L., Jr</creatorcontrib><creatorcontrib>Liu, Y</creatorcontrib><creatorcontrib>McAllister, K</creatorcontrib><creatorcontrib>Friel, C</creatorcontrib><creatorcontrib>Pergola, P. E</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of applied physiology (1985)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kellogg, D. L., Jr</au><au>Liu, Y</au><au>McAllister, K</au><au>Friel, C</au><au>Pergola, P. E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bradykinin does not mediate cutaneous active vasodilation during heat stress in humans</atitle><jtitle>Journal of applied physiology (1985)</jtitle><addtitle>J Appl Physiol (1985)</addtitle><date>2002-10-01</date><risdate>2002</risdate><volume>93</volume><issue>4</issue><spage>1215</spage><epage>1221</epage><pages>1215-1221</pages><issn>8750-7587</issn><eissn>1522-1601</eissn><coden>JAPHEV</coden><abstract>1 Geriatric Research, Education, and Clinical
Center, Department of Veterans Affairs, South Texas Veterans Health
Care System, Audie L. Murphy Memorial Veterans Hospital Division,
and Divisions of 2 Geriatrics and Gerontology and
3 Nephrology, Department of Medicine, University of
Texas Health Science Center at San Antonio, San Antonio, Texas 78229
To test
the hypothesis that bradykinin effects cutaneous active vasodilation
during hyperthermia, we examined whether the increase in skin blood
flow (SkBF) during heat stress was affected by blockade of bradykinin
B 2 receptors with the receptor antagonist HOE-140.
Two adjacent sites on the forearm were instrumented with intradermal
microdialysis probes for local delivery of drugs in eight healthy
subjects. HOE-140 was dissolved in Ringer solution (40 µM) and
perfused at one site, whereas the second site was perfused with Ringer
alone. SkBF was monitored by laser-Doppler flowmetry (LDF) at
both sites. Mean arterial pressure (MAP) was monitored from a finger,
and cutaneous vascular conductance (CVC) was calculated (CVC = LDF/MAP). Water-perfused suits were used to control body temperature
and evoke hyperthermia. After hyperthermia, both microdialysis sites
were perfused with 28 mM nitroprusside to effect maximal vasodilation.
During hyperthermia, CVC increased at HOE-140 (69 ± 2% maximal
CVC, P < 0.01) and untreated sites (65 ± 2%
maximal CVC, P < 0.01). These responses did not differ between sites ( P > 0.05). Because the bradykinin
B 2 -receptor antagonist HOE-140 did not alter SkBF responses
to heat stress, we conclude that bradykinin does not mediate cutaneous
active vasodilation.
microdialysis; laser-Doppler flowmetry</abstract><cop>Bethesda, MD</cop><pub>Am Physiological Soc</pub><pmid>12235017</pmid><doi>10.1152/japplphysiol.01142.2001</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 8750-7587 |
| ispartof | Journal of applied physiology (1985), 2002-10, Vol.93 (4), p.1215-1221 |
| issn | 8750-7587 1522-1601 |
| language | eng |
| recordid | cdi_pascalfrancis_primary_13934299 |
| source | MEDLINE; American Physiological Society; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adult Biological and medical sciences Body fluids Bradykinin - analogs & derivatives Bradykinin - metabolism Bradykinin - pharmacology Bradykinin Receptor Antagonists Endocrine system Female Forearm Fundamental and applied biological sciences. Psychology Heat Hot Temperature Humans Laser-Doppler Flowmetry Male Microdialysis Peptides Receptor, Bradykinin B2 Skin Skin - blood supply Stress, Physiological - physiopathology Thermoregulation. Hibernation. Estivation. Ecophysiology and environmental effects Vasodilation - drug effects Vasodilation - physiology Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | Bradykinin does not mediate cutaneous active vasodilation during heat stress in humans |
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