Suppressive Effect of the Gly389 Allele of the β1-Adrenergic Receptor Gene on the Occurrence of Ventricular Tachycardia in Dilated Cardiomyopathy

Beta-1-adrenergic receptor (β1-AR) blockers reduce both the incidence of sudden death and the ventricular volume in heart failure. In vitro, the Gly389 variant of β1-AR mediates less adenylyl cyclase activities than the Arg389 variant, so Arg389Gly polymorphism was investigated with regard to the ge...

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Veröffentlicht in:	Circulation Journal 2002, Vol.66(8), pp.723-728
Hauptverfasser:	Iwai, Chikao, Akita, Hozuka, Shiga, Nobuyuki, Takai, Eiji, Miyamoto, Yoshitomo, Shimizu, Masakatsu, Kawai, Hiroya, Takarada, Akira, Kajiya, Teishi, Yokoyama, Mitsuhiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Beta-1-adrenergic receptor Biological and medical sciences Cardiology. Vascular system Dilated cardiomyopathy Heart Medical sciences Myocarditis. Cardiomyopathies Ventricular tachycardia
Online-Zugang:	Volltext
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