In vivo activation of N‐methyl‐d‐aspartate receptors in the rat hippocampus increases prostaglandin E2 extracellular levels and triggers lipid peroxidation through cyclooxygenase‐mediated mechanisms

Cyclooxygenases (COX) are a family of enzymes involved in the biosynthesis of prostaglandin (PG) and thromboxanes. The inducible enzyme cyclooxygenase‐2 (COX‐2) is the major isoform found in normal brain, where it is constitutively expressed in neurons and is further up‐regulated during several path...

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Veröffentlicht in:	Journal of neurochemistry 2002-06, Vol.81 (5), p.1028-1034
Hauptverfasser:	Pepicelli, O., Fedele, E., Bonanno, G., Raiteri, M., Ajmone‐Cat, M. A., Greco, A., Levi, G., Minghetti, L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry and metabolism Biological and medical sciences Central nervous system cyclooxygenase excitotoxicity Fundamental and applied biological sciences. Psychology isoprostane neurodegeneration prostaglandin Vertebrates: nervous system and sense organs
Online-Zugang:	Volltext
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