Antimutagenic effect of amino acids on the mutagenicity of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)
The antimutagenic activity of protein-constituting amino acids except histidine on the mutagenicity of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) was investigated in vitro using Salmonella typhinurium TA-100 as an indicator bacterium (Ames test), and concentrations (IC SUB50) of amino acids th...
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| Veröffentlicht in: | Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2002-06, Vol.66 (6), p.1400-1402 |
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| container_title | Bioscience, biotechnology, and biochemistry |
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| creator | Roy, M.K. (Ehime Univ., Matsuyama (Japan). Coll. of Agriculture) Kuwabara, Y Hara, K Watanabe, Y Tamai, Y |
| description | The antimutagenic activity of protein-constituting amino acids except histidine on the mutagenicity of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) was investigated in vitro using Salmonella typhinurium TA-100 as an indicator bacterium (Ames test), and concentrations (IC SUB50) of amino acids that inhibit 50% of the mutagenecity were measured. Cysteine was found to be most active and glycine, tryptophan, lysine, and argi-nine were strong antimutagenic amino acids. Other amino acids showed moderate or weak antimutagenic activities, depending on the amino acids. The results indicate that amino acids play a substantial role in chemoprevention of N-nitroso amine-induced mutagenicity. |
| doi_str_mv | 10.1271/bbb.66.1400 |
| format | Article |
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(Ehime Univ., Matsuyama (Japan). Coll. of Agriculture) ; Kuwabara, Y ; Hara, K ; Watanabe, Y ; Tamai, Y</creator><creatorcontrib>Roy, M.K. (Ehime Univ., Matsuyama (Japan). Coll. of Agriculture) ; Kuwabara, Y ; Hara, K ; Watanabe, Y ; Tamai, Y</creatorcontrib><description>The antimutagenic activity of protein-constituting amino acids except histidine on the mutagenicity of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) was investigated in vitro using Salmonella typhinurium TA-100 as an indicator bacterium (Ames test), and concentrations (IC SUB50) of amino acids that inhibit 50% of the mutagenecity were measured. Cysteine was found to be most active and glycine, tryptophan, lysine, and argi-nine were strong antimutagenic amino acids. Other amino acids showed moderate or weak antimutagenic activities, depending on the amino acids. The results indicate that amino acids play a substantial role in chemoprevention of N-nitroso amine-induced mutagenicity.</description><identifier>ISSN: 0916-8451</identifier><identifier>EISSN: 1347-6947</identifier><identifier>DOI: 10.1271/bbb.66.1400</identifier><identifier>PMID: 12162568</identifier><language>eng</language><publisher>Tokyo: Japan Society for Bioscience, Biotechnology, and Agrochemistry</publisher><subject>amino acid ; AMINO ACIDS ; Amino Acids - pharmacology ; antimutaganic activity ; Antimutagenic Agents - pharmacology ; ANTIMUTAGENS ; Biological and medical sciences ; Cell physiology ; Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes ; CYSTEINE ; Fundamental and applied biological sciences. Psychology ; Inhibitory Concentration 50 ; Methylnitronitrosoguanidine - pharmacology ; MNNG ; Molecular and cellular biology ; Mutagenesis - drug effects ; MUTAGENICITY ; Mutagenicity Tests ; Mutagens - pharmacology ; NITROSAMINES ; SALMONELLA TYPHIMURIUM ; Salmonella typhimurium - drug effects ; Salmonella typhimurium - genetics</subject><ispartof>Bioscience, biotechnology, and biochemistry, 2002-06, Vol.66 (6), p.1400-1402</ispartof><rights>2002 by Japan Society for Bioscience, Biotechnology, and Agrochemistry 2002</rights><rights>2002 INIST-CNRS</rights><rights>Copyright Japan Science and Technology Agency 2002</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c604t-65890511b94aa9168f31da86586e80b8d3497f703f0b0cb27f5388abcb5b61843</citedby><cites>FETCH-LOGICAL-c604t-65890511b94aa9168f31da86586e80b8d3497f703f0b0cb27f5388abcb5b61843</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13807118$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12162568$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Roy, M.K. (Ehime Univ., Matsuyama (Japan). Coll. of Agriculture)</creatorcontrib><creatorcontrib>Kuwabara, Y</creatorcontrib><creatorcontrib>Hara, K</creatorcontrib><creatorcontrib>Watanabe, Y</creatorcontrib><creatorcontrib>Tamai, Y</creatorcontrib><title>Antimutagenic effect of amino acids on the mutagenicity of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)</title><title>Bioscience, biotechnology, and biochemistry</title><addtitle>Biosci Biotechnol Biochem</addtitle><description>The antimutagenic activity of protein-constituting amino acids except histidine on the mutagenicity of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) was investigated in vitro using Salmonella typhinurium TA-100 as an indicator bacterium (Ames test), and concentrations (IC SUB50) of amino acids that inhibit 50% of the mutagenecity were measured. Cysteine was found to be most active and glycine, tryptophan, lysine, and argi-nine were strong antimutagenic amino acids. Other amino acids showed moderate or weak antimutagenic activities, depending on the amino acids. The results indicate that amino acids play a substantial role in chemoprevention of N-nitroso amine-induced mutagenicity.</description><subject>amino acid</subject><subject>AMINO ACIDS</subject><subject>Amino Acids - pharmacology</subject><subject>antimutaganic activity</subject><subject>Antimutagenic Agents - pharmacology</subject><subject>ANTIMUTAGENS</subject><subject>Biological and medical sciences</subject><subject>Cell physiology</subject><subject>Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes</subject><subject>CYSTEINE</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Inhibitory Concentration 50</subject><subject>Methylnitronitrosoguanidine - pharmacology</subject><subject>MNNG</subject><subject>Molecular and cellular biology</subject><subject>Mutagenesis - drug effects</subject><subject>MUTAGENICITY</subject><subject>Mutagenicity Tests</subject><subject>Mutagens - pharmacology</subject><subject>NITROSAMINES</subject><subject>SALMONELLA TYPHIMURIUM</subject><subject>Salmonella typhimurium - drug effects</subject><subject>Salmonella typhimurium - genetics</subject><issn>0916-8451</issn><issn>1347-6947</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpt0M9rFDEUB_Agit1WT56VAREVyZo3yWQyx1K0KnX0oOeQzCTblJmkJhlk__tmndVehMCD8Hk_-CL0DMgW6hbea623nG-BEfIAbYCyFvOOtQ_RhnTAsWANnKDTlG4IKR8NPEYnUAOvGy42yJ777OYlq53xbqiMtWbIVbCVmp0PlRrcmKrgq3xtqn_M5f2B9Hg2-Xo_4f419i7HgPu1prBblHej86Z687XvL98-QY-smpJ5eqxn6OfHDz8uPuGrb5efL86v8MAJy5g3oiMNgO6YUuV4YSmMSpRvbgTRYqSsa21LqCWaDLpubUOFUHrQjeYgGD1DL9e5tzH8WkzK8iYs0ZeVEhjrGGsLK-rdqoZya4rGytvoZhX3Eog8ZCpLppJzeci06BfHmYuezXhvjyEW8OoIVBrUZKPyg0v3jgrSwp-1fHXO2xBn9TvEaZRZ7acQ_zbR_1_wfG20Kki1i8V9-V4TUh6vOdA7xNOYQg</recordid><startdate>20020601</startdate><enddate>20020601</enddate><creator>Roy, M.K. (Ehime Univ., Matsuyama (Japan). Coll. of Agriculture)</creator><creator>Kuwabara, Y</creator><creator>Hara, K</creator><creator>Watanabe, Y</creator><creator>Tamai, Y</creator><general>Japan Society for Bioscience, Biotechnology, and Agrochemistry</general><general>Japan Society for Bioscience Biotechnology and Agrochemistry</general><general>Oxford University Press</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20020601</creationdate><title>Antimutagenic effect of amino acids on the mutagenicity of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)</title><author>Roy, M.K. (Ehime Univ., Matsuyama (Japan). Coll. of Agriculture) ; Kuwabara, Y ; Hara, K ; Watanabe, Y ; Tamai, Y</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c604t-65890511b94aa9168f31da86586e80b8d3497f703f0b0cb27f5388abcb5b61843</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>amino acid</topic><topic>AMINO ACIDS</topic><topic>Amino Acids - pharmacology</topic><topic>antimutaganic activity</topic><topic>Antimutagenic Agents - pharmacology</topic><topic>ANTIMUTAGENS</topic><topic>Biological and medical sciences</topic><topic>Cell physiology</topic><topic>Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes</topic><topic>CYSTEINE</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Inhibitory Concentration 50</topic><topic>Methylnitronitrosoguanidine - pharmacology</topic><topic>MNNG</topic><topic>Molecular and cellular biology</topic><topic>Mutagenesis - drug effects</topic><topic>MUTAGENICITY</topic><topic>Mutagenicity Tests</topic><topic>Mutagens - pharmacology</topic><topic>NITROSAMINES</topic><topic>SALMONELLA TYPHIMURIUM</topic><topic>Salmonella typhimurium - drug effects</topic><topic>Salmonella typhimurium - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Roy, M.K. (Ehime Univ., Matsuyama (Japan). Coll. of Agriculture)</creatorcontrib><creatorcontrib>Kuwabara, Y</creatorcontrib><creatorcontrib>Hara, K</creatorcontrib><creatorcontrib>Watanabe, Y</creatorcontrib><creatorcontrib>Tamai, Y</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Bioscience, biotechnology, and biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Roy, M.K. (Ehime Univ., Matsuyama (Japan). Coll. of Agriculture)</au><au>Kuwabara, Y</au><au>Hara, K</au><au>Watanabe, Y</au><au>Tamai, Y</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antimutagenic effect of amino acids on the mutagenicity of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)</atitle><jtitle>Bioscience, biotechnology, and biochemistry</jtitle><addtitle>Biosci Biotechnol Biochem</addtitle><date>2002-06-01</date><risdate>2002</risdate><volume>66</volume><issue>6</issue><spage>1400</spage><epage>1402</epage><pages>1400-1402</pages><issn>0916-8451</issn><eissn>1347-6947</eissn><abstract>The antimutagenic activity of protein-constituting amino acids except histidine on the mutagenicity of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) was investigated in vitro using Salmonella typhinurium TA-100 as an indicator bacterium (Ames test), and concentrations (IC SUB50) of amino acids that inhibit 50% of the mutagenecity were measured. Cysteine was found to be most active and glycine, tryptophan, lysine, and argi-nine were strong antimutagenic amino acids. Other amino acids showed moderate or weak antimutagenic activities, depending on the amino acids. The results indicate that amino acids play a substantial role in chemoprevention of N-nitroso amine-induced mutagenicity.</abstract><cop>Tokyo</cop><pub>Japan Society for Bioscience, Biotechnology, and Agrochemistry</pub><pmid>12162568</pmid><doi>10.1271/bbb.66.1400</doi><tpages>3</tpages></addata></record> |
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| source | J-STAGE Free; MEDLINE; Oxford University Press Journals Current; Freely Accessible Japanese Titles; EZB-FREE-00999 freely available EZB journals; Free Full-Text Journals in Chemistry |
| subjects | amino acid AMINO ACIDS Amino Acids - pharmacology antimutaganic activity Antimutagenic Agents - pharmacology ANTIMUTAGENS Biological and medical sciences Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes CYSTEINE Fundamental and applied biological sciences. Psychology Inhibitory Concentration 50 Methylnitronitrosoguanidine - pharmacology MNNG Molecular and cellular biology Mutagenesis - drug effects MUTAGENICITY Mutagenicity Tests Mutagens - pharmacology NITROSAMINES SALMONELLA TYPHIMURIUM Salmonella typhimurium - drug effects Salmonella typhimurium - genetics |
| title | Antimutagenic effect of amino acids on the mutagenicity of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) |
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