Alboluxin, a Snake C-type Lectin from Trimeresurus albolabris Venom is a Potent Platelet Agonist acting via GPIb and GPVI

Summary Alboluxin, a potent platelet activator, was purified from Trimeresurus albolabris venom with a mass of 120 kDa non-reduced and, after reduction, subunits of 17 and 24 kDa. Alboluxin induced a tyrosine phosphorylation profile in platelets that resembles those produced by collagen and convulxi...

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Veröffentlicht in:	Thrombosis and haemostasis 2002-04, Vol.87 (4), p.692-698
Hauptverfasser:	Du, Xiao-Yan, Magnenat, Edith, Wells, Timothy N. C., Clemetson, Kenneth J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alprostadil - pharmacology Amino Acid Sequence Animal poisons toxicology. Antivenoms Animals Antibodies, Monoclonal - pharmacology Biological and medical sciences Biotinylation Carrier Proteins Chromatography, Ion Exchange Crotalid Venoms - antagonists & inhibitors Crotalid Venoms - chemistry Crotalid Venoms - isolation & purification Crotalid Venoms - pharmacology Edetic Acid - pharmacology Egtazic Acid - pharmacology Glycosylation Humans Lectins - isolation & purification Lectins - pharmacology Medical sciences Molecular Sequence Data Molecular Weight Phosphorylation Platelet Activation - drug effects Platelet Glycoprotein GPIb-IX Complex - drug effects Platelet Glycoprotein GPIb-IX Complex - immunology Platelet Glycoprotein GPIb-IX Complex - physiology Platelet Glycoprotein GPIIb-IIIa Complex - antagonists & inhibitors Platelet Membrane Glycoproteins - drug effects Platelet Membrane Glycoproteins - immunology Platelet Membrane Glycoproteins - physiology Protein Processing, Post-Translational - drug effects Protein Subunits Proteins - pharmacology Review Article Sequence Alignment Sequence Homology, Amino Acid Stimulation, Chemical Toxicology Viper Venoms
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