Synthesis and Antibacterial Activity of Novel 1β-Methyl Carbapenems with Cycloalkylamine Moiety at the C-2 Position

Synthesis and Antibacterial Activity of Novel 1β-Methyl Carbapenems with Cycloalkylamine Moiety at the C-2 Position

Novel 1β-methyl carbapenems with a cycloalkylamine moiety as a side chain were synthesized and their structure-activity relationships were studied. These carbapenems showed potent antibacterial activities against a wide range of Gram-positive and Gram-negative bacteria, and moderate urinary recovery...

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Veröffentlicht in:Journal of antibiotics 2001/12/25, Vol.54(12), pp.1080-1092
Hauptverfasser: KAWAMOTO, ISAO, SHIMOJI, YASUO, KANNO, OSAMU, ENDO, ROKURO, MIYAUCHI, MASAO, KOJIMA, KATSUHIKO, ISHIKAWA, KATSUYA, MORIMOTO, MUNETSUGU, OHYA, SATOSHI
Format: Artikel
Sprache:eng
Schlagworte:
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
Medical sciences
Pharmacology. Drug treatments
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Zusammenfassung:Novel 1β-methyl carbapenems with a cycloalkylamine moiety as a side chain were synthesized and their structure-activity relationships were studied. These carbapenems showed potent antibacterial activities against a wide range of Gram-positive and Gram-negative bacteria, and moderate urinary recovery when administered intraperitoneally in mice.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.54.1080