Total Synthesis of Bafilomycin V1:  A Methanolysis Product of the Macrolide Bafilomycin C2

A synthesis of bafilomycin V1, a methanolysis product of the macrolide natural product bafilomycin C2, is described. The route utilizes chiral nonracemic allenylzinc reagents, prepared in situ from propargylic mesylates, to access key segments of this methyl ester. The acetylenic moieties of the der...

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Veröffentlicht in:	Journal of organic chemistry 2002-02, Vol.67 (3), p.733-740
Hauptverfasser:	Marshall, James A., Adams, Nicholas D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemistry Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with o, s, se, te hetero atom and condensed derivatives Organic chemistry Preparations and properties
Online-Zugang:	Volltext
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