Transmission of tuberculosis in an endemic urban setting in Brazil
SETTING: Two out-patient facilities in São Paulo, Brazil.OBJECTIVE: To study the transmission pattern of tuberculosis (TB) among human immunodeficiency virus (HIV) infected and uninfected persons in a setting endemic for TB.DESIGN: A prospective study comparing HIV-seropositive and -seronegative TB...
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| Veröffentlicht in: | The international journal of tuberculosis and lung disease 2000-01, Vol.4 (1), p.18-25 |
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| creator | FERRAZOLI, L PALACI, M SPADA, D. T. A RILEY, L. W MARQUES, L. R. M JAMAL, L. F AFIUNE, J. B CHIMARA, E MARTINS, M. C DA SILVA TELLES, M. A OLIVEIRA, C. A. F PALHARES, M. C |
| description | SETTING: Two out-patient facilities in São Paulo, Brazil.OBJECTIVE: To study the transmission pattern of tuberculosis (TB) among human immunodeficiency virus (HIV) infected and uninfected persons in a setting endemic for TB.DESIGN: A prospective study comparing HIV-seropositive
and -seronegative TB patients identified consecutively between 1 March 1995 and 1 April 1997. The patients were stratified according to their Mycobacterium tuberculosis isolate IS6110 RFLP patterns. Risk factors were sought for infection with an RFLP cluster pattern strain, inferred
to represent recent transmission.RESULTS: Fifty-eight (38%) of 151 HIV-seropositive patients and 36 (25%) of 142 HIV-seronegative patients were infected with M. tuberculosis isolates that belonged to cluster patterns (OR 1.84, 95%CI 1.08-3.13). Multidrug-resistant (MDR) strains
were isolated from 19 patients, all of whom were HIV seropositive; 12 (63%) of these, and 46 (35%) of 132 drug-susceptible isolates had cluster patterns (OR 3.20, 95%CI 1.08-9.77).CONCLUSION: In a TB-endemic urban setting in Brazil, the proportion of cases resulting from recent transmission
appears to be greater among HIV-seropositive than among HIV-seronegative patients. A large proportion of MDR-TB (63%) cases was caused by strains that had cluster RFLP patterns, suggesting recent transmission of already resistant organisms. This type of knowledge regarding TB transmission
may help to improve locally appropriate TB control programs. |
| format | Article |
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and -seronegative TB patients identified consecutively between 1 March 1995 and 1 April 1997. The patients were stratified according to their Mycobacterium tuberculosis isolate IS6110 RFLP patterns. Risk factors were sought for infection with an RFLP cluster pattern strain, inferred
to represent recent transmission.RESULTS: Fifty-eight (38%) of 151 HIV-seropositive patients and 36 (25%) of 142 HIV-seronegative patients were infected with M. tuberculosis isolates that belonged to cluster patterns (OR 1.84, 95%CI 1.08-3.13). Multidrug-resistant (MDR) strains
were isolated from 19 patients, all of whom were HIV seropositive; 12 (63%) of these, and 46 (35%) of 132 drug-susceptible isolates had cluster patterns (OR 3.20, 95%CI 1.08-9.77).CONCLUSION: In a TB-endemic urban setting in Brazil, the proportion of cases resulting from recent transmission
appears to be greater among HIV-seropositive than among HIV-seronegative patients. A large proportion of MDR-TB (63%) cases was caused by strains that had cluster RFLP patterns, suggesting recent transmission of already resistant organisms. This type of knowledge regarding TB transmission
may help to improve locally appropriate TB control programs.</description><identifier>ISSN: 1027-3719</identifier><identifier>EISSN: 1815-7920</identifier><identifier>PMID: 10654639</identifier><language>eng</language><publisher>Paris, France: IUATLD</publisher><subject>Adolescent ; Adult ; Aged ; AIDS-Related Opportunistic Infections - epidemiology ; AIDS-Related Opportunistic Infections - microbiology ; AIDS-Related Opportunistic Infections - transmission ; AIDS/HIV ; Bacterial diseases ; Biological and medical sciences ; Brazil ; Brazil - epidemiology ; Female ; Human bacterial diseases ; Humans ; Infectious diseases ; Male ; Medical sciences ; Middle Aged ; Multidrug-Resistant Tb ; Mycobacterium tuberculosis - isolation & purification ; Polymorphism, Restriction Fragment Length ; Prospective Studies ; RFLP ; Risk Factors ; Transmission ; Tropical medicine ; Tuberculosis ; Tuberculosis and atypical mycobacterial infections ; Tuberculosis, Multidrug-Resistant - epidemiology ; Tuberculosis, Multidrug-Resistant - transmission ; Tuberculosis, Pulmonary - epidemiology ; Tuberculosis, Pulmonary - transmission ; Urban Health</subject><ispartof>The international journal of tuberculosis and lung disease, 2000-01, Vol.4 (1), p.18-25</ispartof><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1257221$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10654639$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>FERRAZOLI, L</creatorcontrib><creatorcontrib>PALACI, M</creatorcontrib><creatorcontrib>SPADA, D. T. A</creatorcontrib><creatorcontrib>RILEY, L. W</creatorcontrib><creatorcontrib>MARQUES, L. R. M</creatorcontrib><creatorcontrib>JAMAL, L. F</creatorcontrib><creatorcontrib>AFIUNE, J. B</creatorcontrib><creatorcontrib>CHIMARA, E</creatorcontrib><creatorcontrib>MARTINS, M. C</creatorcontrib><creatorcontrib>DA SILVA TELLES, M. A</creatorcontrib><creatorcontrib>OLIVEIRA, C. A. F</creatorcontrib><creatorcontrib>PALHARES, M. C</creatorcontrib><title>Transmission of tuberculosis in an endemic urban setting in Brazil</title><title>The international journal of tuberculosis and lung disease</title><addtitle>Int J Tuberc Lung Dis</addtitle><description>SETTING: Two out-patient facilities in São Paulo, Brazil.OBJECTIVE: To study the transmission pattern of tuberculosis (TB) among human immunodeficiency virus (HIV) infected and uninfected persons in a setting endemic for TB.DESIGN: A prospective study comparing HIV-seropositive
and -seronegative TB patients identified consecutively between 1 March 1995 and 1 April 1997. The patients were stratified according to their Mycobacterium tuberculosis isolate IS6110 RFLP patterns. Risk factors were sought for infection with an RFLP cluster pattern strain, inferred
to represent recent transmission.RESULTS: Fifty-eight (38%) of 151 HIV-seropositive patients and 36 (25%) of 142 HIV-seronegative patients were infected with M. tuberculosis isolates that belonged to cluster patterns (OR 1.84, 95%CI 1.08-3.13). Multidrug-resistant (MDR) strains
were isolated from 19 patients, all of whom were HIV seropositive; 12 (63%) of these, and 46 (35%) of 132 drug-susceptible isolates had cluster patterns (OR 3.20, 95%CI 1.08-9.77).CONCLUSION: In a TB-endemic urban setting in Brazil, the proportion of cases resulting from recent transmission
appears to be greater among HIV-seropositive than among HIV-seronegative patients. A large proportion of MDR-TB (63%) cases was caused by strains that had cluster RFLP patterns, suggesting recent transmission of already resistant organisms. This type of knowledge regarding TB transmission
may help to improve locally appropriate TB control programs.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>AIDS-Related Opportunistic Infections - epidemiology</subject><subject>AIDS-Related Opportunistic Infections - microbiology</subject><subject>AIDS-Related Opportunistic Infections - transmission</subject><subject>AIDS/HIV</subject><subject>Bacterial diseases</subject><subject>Biological and medical sciences</subject><subject>Brazil</subject><subject>Brazil - epidemiology</subject><subject>Female</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Multidrug-Resistant Tb</subject><subject>Mycobacterium tuberculosis - isolation & purification</subject><subject>Polymorphism, Restriction Fragment Length</subject><subject>Prospective Studies</subject><subject>RFLP</subject><subject>Risk Factors</subject><subject>Transmission</subject><subject>Tropical medicine</subject><subject>Tuberculosis</subject><subject>Tuberculosis and atypical mycobacterial infections</subject><subject>Tuberculosis, Multidrug-Resistant - epidemiology</subject><subject>Tuberculosis, Multidrug-Resistant - transmission</subject><subject>Tuberculosis, Pulmonary - epidemiology</subject><subject>Tuberculosis, Pulmonary - transmission</subject><subject>Urban Health</subject><issn>1027-3719</issn><issn>1815-7920</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kEtLxDAUhYsoOj7-gnQh7go3r6Zd6vgEwY2uL2maSoZOqnkIzq83ZWZwZRbJCfnuIeccFAvSEFHJlsJh1kBlxSRpT4rTEFYAlBAij4sTArXgNWsXxe2bVy6sbQh2cuU0lDF1xus0TsGG0rpSudK43qytLpPv8i2YGK37mN9uvdrY8bw4GtQYzMXuPCveH-7flk_Vy-vj8_LmpbKsbmOlVVOL1hjSNcAHrntGhSZcDpLUptFMN1LWYHraKQ5ctlBzTkFIxgZoiZLsrLje-n766SuZEDF_W5txVM5MKaCERkKeyuDlDkzd2vT46e1a-R_cp87A1Q5QQatxyBVoG_44KiSlJGOvWyzHNS4qXE3JuxwRrUabVBx7nCueG8Zv7gjS3DA0VCARhGJvBpXGiFF5_NhgENnx7j_HrZ1dzTsFAITt4ntBUPk4C8F-ATBWkEA</recordid><startdate>20000101</startdate><enddate>20000101</enddate><creator>FERRAZOLI, L</creator><creator>PALACI, M</creator><creator>SPADA, D. T. A</creator><creator>RILEY, L. W</creator><creator>MARQUES, L. R. M</creator><creator>JAMAL, L. F</creator><creator>AFIUNE, J. B</creator><creator>CHIMARA, E</creator><creator>MARTINS, M. C</creator><creator>DA SILVA TELLES, M. A</creator><creator>OLIVEIRA, C. A. F</creator><creator>PALHARES, M. C</creator><general>IUATLD</general><general>Union internationale contre la tuberculose et les maladies respiratoires</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20000101</creationdate><title>Transmission of tuberculosis in an endemic urban setting in Brazil</title><author>FERRAZOLI, L ; PALACI, M ; SPADA, D. T. A ; RILEY, L. W ; MARQUES, L. R. M ; JAMAL, L. F ; AFIUNE, J. B ; CHIMARA, E ; MARTINS, M. C ; DA SILVA TELLES, M. A ; OLIVEIRA, C. A. F ; PALHARES, M. C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i369t-ca8659ee1b804f4cd325c147f716e8c3c87760ed2ba404790644205733f091a73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>AIDS-Related Opportunistic Infections - epidemiology</topic><topic>AIDS-Related Opportunistic Infections - microbiology</topic><topic>AIDS-Related Opportunistic Infections - transmission</topic><topic>AIDS/HIV</topic><topic>Bacterial diseases</topic><topic>Biological and medical sciences</topic><topic>Brazil</topic><topic>Brazil - epidemiology</topic><topic>Female</topic><topic>Human bacterial diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Multidrug-Resistant Tb</topic><topic>Mycobacterium tuberculosis - isolation & purification</topic><topic>Polymorphism, Restriction Fragment Length</topic><topic>Prospective Studies</topic><topic>RFLP</topic><topic>Risk Factors</topic><topic>Transmission</topic><topic>Tropical medicine</topic><topic>Tuberculosis</topic><topic>Tuberculosis and atypical mycobacterial infections</topic><topic>Tuberculosis, Multidrug-Resistant - epidemiology</topic><topic>Tuberculosis, Multidrug-Resistant - transmission</topic><topic>Tuberculosis, Pulmonary - epidemiology</topic><topic>Tuberculosis, Pulmonary - transmission</topic><topic>Urban Health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>FERRAZOLI, L</creatorcontrib><creatorcontrib>PALACI, M</creatorcontrib><creatorcontrib>SPADA, D. T. A</creatorcontrib><creatorcontrib>RILEY, L. W</creatorcontrib><creatorcontrib>MARQUES, L. R. M</creatorcontrib><creatorcontrib>JAMAL, L. F</creatorcontrib><creatorcontrib>AFIUNE, J. B</creatorcontrib><creatorcontrib>CHIMARA, E</creatorcontrib><creatorcontrib>MARTINS, M. C</creatorcontrib><creatorcontrib>DA SILVA TELLES, M. A</creatorcontrib><creatorcontrib>OLIVEIRA, C. A. F</creatorcontrib><creatorcontrib>PALHARES, M. C</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>The international journal of tuberculosis and lung disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>FERRAZOLI, L</au><au>PALACI, M</au><au>SPADA, D. T. A</au><au>RILEY, L. W</au><au>MARQUES, L. R. M</au><au>JAMAL, L. F</au><au>AFIUNE, J. B</au><au>CHIMARA, E</au><au>MARTINS, M. C</au><au>DA SILVA TELLES, M. A</au><au>OLIVEIRA, C. A. F</au><au>PALHARES, M. C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Transmission of tuberculosis in an endemic urban setting in Brazil</atitle><jtitle>The international journal of tuberculosis and lung disease</jtitle><addtitle>Int J Tuberc Lung Dis</addtitle><date>2000-01-01</date><risdate>2000</risdate><volume>4</volume><issue>1</issue><spage>18</spage><epage>25</epage><pages>18-25</pages><issn>1027-3719</issn><eissn>1815-7920</eissn><abstract>SETTING: Two out-patient facilities in São Paulo, Brazil.OBJECTIVE: To study the transmission pattern of tuberculosis (TB) among human immunodeficiency virus (HIV) infected and uninfected persons in a setting endemic for TB.DESIGN: A prospective study comparing HIV-seropositive
and -seronegative TB patients identified consecutively between 1 March 1995 and 1 April 1997. The patients were stratified according to their Mycobacterium tuberculosis isolate IS6110 RFLP patterns. Risk factors were sought for infection with an RFLP cluster pattern strain, inferred
to represent recent transmission.RESULTS: Fifty-eight (38%) of 151 HIV-seropositive patients and 36 (25%) of 142 HIV-seronegative patients were infected with M. tuberculosis isolates that belonged to cluster patterns (OR 1.84, 95%CI 1.08-3.13). Multidrug-resistant (MDR) strains
were isolated from 19 patients, all of whom were HIV seropositive; 12 (63%) of these, and 46 (35%) of 132 drug-susceptible isolates had cluster patterns (OR 3.20, 95%CI 1.08-9.77).CONCLUSION: In a TB-endemic urban setting in Brazil, the proportion of cases resulting from recent transmission
appears to be greater among HIV-seropositive than among HIV-seronegative patients. A large proportion of MDR-TB (63%) cases was caused by strains that had cluster RFLP patterns, suggesting recent transmission of already resistant organisms. This type of knowledge regarding TB transmission
may help to improve locally appropriate TB control programs.</abstract><cop>Paris, France</cop><pub>IUATLD</pub><pmid>10654639</pmid><tpages>8</tpages></addata></record> |
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| subjects | Adolescent Adult Aged AIDS-Related Opportunistic Infections - epidemiology AIDS-Related Opportunistic Infections - microbiology AIDS-Related Opportunistic Infections - transmission AIDS/HIV Bacterial diseases Biological and medical sciences Brazil Brazil - epidemiology Female Human bacterial diseases Humans Infectious diseases Male Medical sciences Middle Aged Multidrug-Resistant Tb Mycobacterium tuberculosis - isolation & purification Polymorphism, Restriction Fragment Length Prospective Studies RFLP Risk Factors Transmission Tropical medicine Tuberculosis Tuberculosis and atypical mycobacterial infections Tuberculosis, Multidrug-Resistant - epidemiology Tuberculosis, Multidrug-Resistant - transmission Tuberculosis, Pulmonary - epidemiology Tuberculosis, Pulmonary - transmission Urban Health |
| title | Transmission of tuberculosis in an endemic urban setting in Brazil |
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