Mathematical model of antibody targeting: important parameters defined using clinical data

Antibody-targeted therapy of cancer has shown benefits in the treatment of some cancers but selective delivery has not been optimized. Many parameters influence antibody targeting; some will have a greater effect than others and their effects will generally be interrelated. They include effects of b...

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Veröffentlicht in:	Physics in medicine & biology 2001-06, Vol.46 (6), p.1679-1693
Hauptverfasser:	Green, A J, Johnson, C J, Adamson, K L, Begent, R H J
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigen-Antibody Reactions Biological and medical sciences Carcinoembryonic Antigen - immunology Carcinoembryonic Antigen - metabolism Clinical Trials as Topic Colorectal Neoplasms - immunology Colorectal Neoplasms - metabolism Colorectal Neoplasms - therapy Combined treatment Contrast media. Radiopharmaceuticals Humans Liver - immunology Liver - physiology Medical sciences Models, Theoretical Pharmacology. Drug treatments Time Factors Treatment. General aspects Tumors
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