Metabolism of styrene in the human liver in vitro: interindividual variation and enantioselectivity

1. The interindividual variation and enantioselectivity of the in vitro styrene oxidation by cytochrome P450 have been investigated in 20 human microsomal liver samples. Liver samples were genotyped for the CYP2E1*6 and CYP2E1*5B alleles. 2. Kinetic analysis indicated the presence of at least two fo...

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Veröffentlicht in:	Xenobiotica 2001-02, Vol.31 (2), p.61-72
Hauptverfasser:	WENKER, M. A. M., KE I, S., MONSTER, A. C., DE WOLFF, F. A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aryl Hydrocarbon Hydroxylases Biological and medical sciences Chemical and industrial products toxicology. Toxic occupational diseases Cytochrome P-450 CYP1A2 Cytochrome P-450 CYP2C8 Cytochrome P-450 CYP2E1 - genetics Cytochrome P-450 CYP2E1 - metabolism Cytochrome P-450 CYP2E1 Inhibitors Cytochrome P-450 CYP3A Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Enzyme System - metabolism Enzyme Inhibitors - pharmacology Fomepizole Genetic Variation Humans Liver - drug effects Liver - metabolism Male Medical sciences Middle Aged Mixed Function Oxygenases - metabolism Oxidation-Reduction Polymorphism, Genetic Pyrazoles - pharmacology Solvents Steroid 16-alpha-Hydroxylase Steroid Hydroxylases - antagonists & inhibitors Steroid Hydroxylases - metabolism Styrene - metabolism styrene oxide Toxicology
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