S34. DEVELOPMENTAL TRAJECTORIES OF PSYCHOTIC EXPERIENCES AND THEORY OF MIND IN 11-YEAR-OLD OFFSPRING OF PARENTS WITH SCHIZOPHRENIA OR BIPOLAR DISORDER

Abstract Background The study is a part of the Danish High Risk and Resilience Study, Via 11 and aims to explore the developmental trajectories of psychotic experiences (PEs) and theory of mind in children born to parents with schizophrenia or bipolar disorder. In a cross sectional perspective we also aim to explore possible associations between PEs and social cognitive deficits, particularly hyper-theory-of-mind. We also wish to explore the significance of other potential risk factors for PEs such as cognitive biases, adverse life events, and insecure attachment styles. Earlier studies have shown that PEs during childhood are predictive of later psychotic disorders, especially if they persist over time. We expect the possible risk factors to have a cumulative effect. Methods The Danish High Risk and Resilience Study, Via 11, is the first follow-up of a cohort of 522 children and their parents. The cohort consists of children where one or both parents have been diagnosed with a schizophrenia spectrum disorder (N=202), children where one or both parents have been diagnosed with bipolar affective disorder (N=120) and children where neither of the parents have been diagnosed with these disorders (N=200). The children and their parents were assessed with a comprehensive assessment battery e.g. social- and neurocognitive tests and diagnostic interviews when the children were seven years old, and they will now be re-assessed for the first time at age 11. Data for this study is currently being collected as a part of the Via 11. Psychotic experiences will be assessed on the Scale of Prodromal Symptoms based on K-SADS interviews and with the Magical Thinking Questionnaire. Social cognitive skills will be assessed with Frith-Happé Animated Triangles and Theory-of-Mind Storybook Frederik. Cognitive bias i.e. jumping to conclusions will be assessed with the Beads task. Adverse life events will be assessed with the K-SADS interviews, the Child Trauma Screening Questionnaire, and with a questionnaire about bullying based on the Olweus Bully/Victim Questionnaire. Measures of neurocognitive and attentional deficits will also be included. Child attachment style was assessed with the Story Stem Assessment Protocol and emotion recognition with the ERT from Cantab. Hypotheses: -Age seven: Children in the two high risk groups will be have higher rates of insecure or disorganized attachment styles compared with children in the control group. We expect insecure and disorganized