SARS-CoV-2 Seroprevalence Survey Estimates Are Affected by Anti-Nucleocapsid Antibody Decline

SARS-CoV-2 Seroprevalence Survey Estimates Are Affected by Anti-Nucleocapsid Antibody Decline

Abstract We analyzed 21 676 residual specimens from Ontario, Canada collected March–August 2020 to investigate the effect of antibody decline on SARS-CoV-2 seroprevalence estimates. Testing specimens orthogonally using Abbott (anti-nucleocapsid) and Ortho (anti-spike) assays, seroprevalence estimate...

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Veröffentlicht in:The Journal of infectious diseases 2021-04, Vol.223 (8), p.1334-1338
Hauptverfasser: Bolotin, Shelly, Tran, Vanessa, Osman, Selma, Brown, Kevin A, Buchan, Sarah A, Joh, Eugene, Deeks, Shelley L, Allen, Vanessa G
Format: Artikel
Sprache:eng
Schlagworte:
Antibodies
Antibodies, Viral - blood
Antibodies, Viral - immunology
Brief Report
Canada
Coronavirus Nucleocapsid Proteins - immunology
COVID-19 - blood
COVID-19 - immunology
COVID-19 Serological Testing - methods
Cross-Sectional Studies
Humans
Immunity (Disease)
Immunology
Infectious Diseases
Life Sciences & Biomedicine
Microbiology
Nucleocapsids
Phosphoproteins - immunology
SARS-CoV-2 - immunology
Science & Technology
Seroepidemiologic Studies
Serology
Severe acute respiratory syndrome coronavirus 2
Spike Glycoprotein, Coronavirus - immunology
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Zusammenfassung:Abstract We analyzed 21 676 residual specimens from Ontario, Canada collected March–August 2020 to investigate the effect of antibody decline on SARS-CoV-2 seroprevalence estimates. Testing specimens orthogonally using Abbott (anti-nucleocapsid) and Ortho (anti-spike) assays, seroprevalence estimates were 0.4%–1.4%, despite ongoing disease activity. The geometric mean concentration (GMC) of antibody-positive specimens decreased over time (P = .015), and GMC of antibody-negative specimens increased over time (P = .0018). Association between the 2 tests decreased each month (P 
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/jiaa796