Selective Decay of Intact HIV-1 Proviral DNA on Antiretroviral Therapy

Abstract Background HIV-1 proviruses persist in people on antiretroviral therapy (ART) but most are defective and do not constitute a replication-competent reservoir. The decay of infected cells carrying intact compared with defective HIV-1 proviruses has not been well defined in people on ART. Meth...

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Veröffentlicht in:	The Journal of infectious diseases 2021-02, Vol.223 (2), p.225-233
Hauptverfasser:	Gandhi, Rajesh T, Cyktor, Joshua C, Bosch, Ronald J, Mar, Hanna, Laird, Gregory M, Martin, Albine, Collier, Ann C, Riddler, Sharon A, Macatangay, Bernard J, Rinaldo, Charles R, Eron, Joseph J, Siliciano, Janet D, McMahon, Deborah K, Mellors, John W
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiretroviral drugs Antiretroviral therapy Cell activation Deoxyribonucleic acid DNA Drug therapy HIV Human immunodeficiency virus Immune response Immunology Infectious Diseases Inflammation Life Sciences & Biomedicine Major and Brief Reports Microbiology Proviruses Replication Science & Technology Viremia
Online-Zugang:	Volltext
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