121PAXL expression predicts poor prognosis and lack of efficacy of anti-angiogenic and anti-epidermal growth factor receptor (EGFR) agents in patients (pts) with RAS wild type (WT) metastatic colorectal cancer (mCRC)

Abstract Background Activation of AXL receptor tyrosine kinase is a key mediator of epithelial to mesenchymal transition (EMT). AXL is overexpressed in several human cancers, including CRC. Methods AXL expression was assessed by immunohistochemistry in tumor samples from 346 mCRC pts treated at thre...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Annals of oncology 2019-10, Vol.30 (Supplement_5)
Hauptverfasser:	Cardone, C, Blauensteiner, B, Moreno-Viedma, V, Vitiello, P P, Martini, G, Ciardiello, D, Simeon, V, Rachiglio, A M, Rizzi, D, Maiello, E, Latiano, T, Cremolini, C, Argiles Martinez, G, Elez, E, Falcone, A, Tabernero, J, Normanno, N, Sibilia, M, Ciardiello, F, Martinelli, E
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!