467PFGFR INHIBITOR AND CHEMOTHERAPY IN GASTRIC CANCER (FACING): PHASE I RESULTS FROM AN ECMC COMBINATIONS ALLIANCE PHASE I/II TRIAL OF AZD4547 IN COMBINATION WITH CISPLATIN AND CAPECITABINE (CX)

Abstract Aim: Fibroblast growth factors (FGFs) and their receptors (FGFRs) control a wide range of biological functions, and are implicated in the pathogenesis of diverse tumour types including gastro-oesophageal adenocarcinoma (OGA). AZD4547 is a potent, selective, small molecule inhibitor of FGFR...

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Veröffentlicht in:	Annals of oncology 2014-09, Vol.25 (suppl_4), p.iv155-iv156
Hauptverfasser:	Lindsay, C., Thistlethwaite, F., Gupta, A., Mansoor, W., Lewsley, L., Hubner, R., Hopkins, C.A., Chan, K., McDowell, C., Campbell, S., Douglas, L., Bray, C., Ranson, M., Dive, C., Middleton, M.R., Landers, D., Evans, T.R..J.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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