Biotin-deficient diet induces chromosome misalignment and spindle defects in mouse oocytes
Increased abnormal oocytes due to meiotic chromosome misalignment and spindle defects lead to elevated rates of infertility, miscarriage, and trisomic conceptions. Here, we investigated the effect of biotin deficiency on oocyte quality. Three-week-old female ICR mice were fed a biotin-deficient or c...
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| Veröffentlicht in: | Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2015-02, Vol.79 (2), p.292-299 |
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| creator | Tsuji, Ai Nakamura, Toshinobu Shibata, Katsumi |
| description | Increased abnormal oocytes due to meiotic chromosome misalignment and spindle defects lead to elevated rates of infertility, miscarriage, and trisomic conceptions. Here, we investigated the effect of biotin deficiency on oocyte quality. Three-week-old female ICR mice were fed a biotin-deficient or control diet (0, 0.004 g biotin/kg diet) for 21 days. On day 22, these mouse oocytes were analyzed by immunofluorescence. Due to biotin, undernutrition increased the frequency of abnormal oocytes (the biotin deficient vs. control: 40 vs. 16%). Next, the remaining mice in the biotin-deficient group were fed a control or biotin-deficient diet from day 22 to 42. Although biotin nutritional status in the recovery group was restored, the frequency of abnormal oocytes in the recovery group was still higher than that in the control group (48 vs. 18%). Our results indicate that steady, sufficient biotin intake is required for the production of high-quality oocytes in mice.
Biotin-deficient diet induces chromosome misalignment and spindle defects in mouse oocytes that persist even after biotin is re-administered. |
| doi_str_mv | 10.1080/09168451.2014.968090 |
| format | Article |
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Biotin-deficient diet induces chromosome misalignment and spindle defects in mouse oocytes that persist even after biotin is re-administered.</description><identifier>ISSN: 0916-8451</identifier><identifier>EISSN: 1347-6947</identifier><identifier>DOI: 10.1080/09168451.2014.968090</identifier><identifier>PMID: 25301108</identifier><language>eng</language><publisher>England: Taylor & Francis</publisher><subject>Animals ; biotin ; Biotin - deficiency ; Biotin - urine ; Body Weight ; Cell Count ; Chromosome Aberrations ; deficiency ; Diet ; Eating ; Estradiol - blood ; Estrous Cycle ; Female ; Liver - metabolism ; Mice ; Mice, Inbred ICR ; mouse ; oocyte quality ; Oocytes - cytology ; Oocytes - metabolism ; Organ Size ; Ovary - growth & development ; Ovary - metabolism ; Ovary - physiology ; Spindle Apparatus ; Uterus - growth & development ; Uterus - metabolism ; Uterus - physiology ; Valerates - urine</subject><ispartof>Bioscience, biotechnology, and biochemistry, 2015-02, Vol.79 (2), p.292-299</ispartof><rights>2014 Japan Society for Bioscience, Biotechnology, and Agrochemistry 2014</rights><rights>2015 Japan Society for Bioscience, Biotechnology, and Agrochemistry 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c539t-2d453148c25108669bafe8c6c55d1dbafea282ba44732c5a3720ca489bc0fa953</citedby><cites>FETCH-LOGICAL-c539t-2d453148c25108669bafe8c6c55d1dbafea282ba44732c5a3720ca489bc0fa953</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27926,27927</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25301108$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tsuji, Ai</creatorcontrib><creatorcontrib>Nakamura, Toshinobu</creatorcontrib><creatorcontrib>Shibata, Katsumi</creatorcontrib><title>Biotin-deficient diet induces chromosome misalignment and spindle defects in mouse oocytes</title><title>Bioscience, biotechnology, and biochemistry</title><addtitle>Biosci Biotechnol Biochem</addtitle><description>Increased abnormal oocytes due to meiotic chromosome misalignment and spindle defects lead to elevated rates of infertility, miscarriage, and trisomic conceptions. Here, we investigated the effect of biotin deficiency on oocyte quality. Three-week-old female ICR mice were fed a biotin-deficient or control diet (0, 0.004 g biotin/kg diet) for 21 days. On day 22, these mouse oocytes were analyzed by immunofluorescence. Due to biotin, undernutrition increased the frequency of abnormal oocytes (the biotin deficient vs. control: 40 vs. 16%). Next, the remaining mice in the biotin-deficient group were fed a control or biotin-deficient diet from day 22 to 42. Although biotin nutritional status in the recovery group was restored, the frequency of abnormal oocytes in the recovery group was still higher than that in the control group (48 vs. 18%). Our results indicate that steady, sufficient biotin intake is required for the production of high-quality oocytes in mice.
Biotin-deficient diet induces chromosome misalignment and spindle defects in mouse oocytes that persist even after biotin is re-administered.</description><subject>Animals</subject><subject>biotin</subject><subject>Biotin - deficiency</subject><subject>Biotin - urine</subject><subject>Body Weight</subject><subject>Cell Count</subject><subject>Chromosome Aberrations</subject><subject>deficiency</subject><subject>Diet</subject><subject>Eating</subject><subject>Estradiol - blood</subject><subject>Estrous Cycle</subject><subject>Female</subject><subject>Liver - metabolism</subject><subject>Mice</subject><subject>Mice, Inbred ICR</subject><subject>mouse</subject><subject>oocyte quality</subject><subject>Oocytes - cytology</subject><subject>Oocytes - metabolism</subject><subject>Organ Size</subject><subject>Ovary - growth & development</subject><subject>Ovary - metabolism</subject><subject>Ovary - physiology</subject><subject>Spindle Apparatus</subject><subject>Uterus - growth & development</subject><subject>Uterus - metabolism</subject><subject>Uterus - physiology</subject><subject>Valerates - urine</subject><issn>0916-8451</issn><issn>1347-6947</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkMtKxDAARYMozjj6ByJduumYZx8r0cEXDLjRjZuQJqlG2mRMUmT-3pTOuBRXIeGcm8sF4BzBJYIVvII1KirK0BJDRJd1UcEaHoA5IrTMi5qWh2A-IvnIzMBJCJ8QpgeGjsEMMwJRSpmDt1vjorG50q2RRtuYKaNjZqwapA6Z_PCud8H1OutNEJ15t_0ICauysElUp7OkahlDcrLeDUFnzslt1OEUHLWiC_psdy7A6_3dy-oxXz8_PK1u1rlkpI45VpQRRCuJWWpUFHUjWl3JQjKmkBovAle4EZSWBEsmSImhFLSqGwlbUTOyAJdT7sa7r0GHyFNVqbtOWJ36cFSwAlJWkjKhdEKldyF43fKNN73wW44gH1fl-1X5uCqfVk3axe6Hoem1-pX2MybgagLcsPlv5PVkGNs634tv5zvFo9h2zrdeWGkCJ38m_AAM6JSz</recordid><startdate>20150201</startdate><enddate>20150201</enddate><creator>Tsuji, Ai</creator><creator>Nakamura, Toshinobu</creator><creator>Shibata, Katsumi</creator><general>Taylor & Francis</general><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20150201</creationdate><title>Biotin-deficient diet induces chromosome misalignment and spindle defects in mouse oocytes</title><author>Tsuji, Ai ; Nakamura, Toshinobu ; Shibata, Katsumi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c539t-2d453148c25108669bafe8c6c55d1dbafea282ba44732c5a3720ca489bc0fa953</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Animals</topic><topic>biotin</topic><topic>Biotin - deficiency</topic><topic>Biotin - urine</topic><topic>Body Weight</topic><topic>Cell Count</topic><topic>Chromosome Aberrations</topic><topic>deficiency</topic><topic>Diet</topic><topic>Eating</topic><topic>Estradiol - blood</topic><topic>Estrous Cycle</topic><topic>Female</topic><topic>Liver - metabolism</topic><topic>Mice</topic><topic>Mice, Inbred ICR</topic><topic>mouse</topic><topic>oocyte quality</topic><topic>Oocytes - cytology</topic><topic>Oocytes - metabolism</topic><topic>Organ Size</topic><topic>Ovary - growth & development</topic><topic>Ovary - metabolism</topic><topic>Ovary - physiology</topic><topic>Spindle Apparatus</topic><topic>Uterus - growth & development</topic><topic>Uterus - metabolism</topic><topic>Uterus - physiology</topic><topic>Valerates - urine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tsuji, Ai</creatorcontrib><creatorcontrib>Nakamura, Toshinobu</creatorcontrib><creatorcontrib>Shibata, Katsumi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Bioscience, biotechnology, and biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tsuji, Ai</au><au>Nakamura, Toshinobu</au><au>Shibata, Katsumi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Biotin-deficient diet induces chromosome misalignment and spindle defects in mouse oocytes</atitle><jtitle>Bioscience, biotechnology, and biochemistry</jtitle><addtitle>Biosci Biotechnol Biochem</addtitle><date>2015-02-01</date><risdate>2015</risdate><volume>79</volume><issue>2</issue><spage>292</spage><epage>299</epage><pages>292-299</pages><issn>0916-8451</issn><eissn>1347-6947</eissn><abstract>Increased abnormal oocytes due to meiotic chromosome misalignment and spindle defects lead to elevated rates of infertility, miscarriage, and trisomic conceptions. Here, we investigated the effect of biotin deficiency on oocyte quality. Three-week-old female ICR mice were fed a biotin-deficient or control diet (0, 0.004 g biotin/kg diet) for 21 days. On day 22, these mouse oocytes were analyzed by immunofluorescence. Due to biotin, undernutrition increased the frequency of abnormal oocytes (the biotin deficient vs. control: 40 vs. 16%). Next, the remaining mice in the biotin-deficient group were fed a control or biotin-deficient diet from day 22 to 42. Although biotin nutritional status in the recovery group was restored, the frequency of abnormal oocytes in the recovery group was still higher than that in the control group (48 vs. 18%). Our results indicate that steady, sufficient biotin intake is required for the production of high-quality oocytes in mice.
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| ispartof | Bioscience, biotechnology, and biochemistry, 2015-02, Vol.79 (2), p.292-299 |
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| source | MEDLINE; Freely Accessible Japanese Titles - check A-Z of ejournals; AUTh Library subscriptions: Oxford University Press; EZB Electronic Journals Library |
| subjects | Animals biotin Biotin - deficiency Biotin - urine Body Weight Cell Count Chromosome Aberrations deficiency Diet Eating Estradiol - blood Estrous Cycle Female Liver - metabolism Mice Mice, Inbred ICR mouse oocyte quality Oocytes - cytology Oocytes - metabolism Organ Size Ovary - growth & development Ovary - metabolism Ovary - physiology Spindle Apparatus Uterus - growth & development Uterus - metabolism Uterus - physiology Valerates - urine |
| title | Biotin-deficient diet induces chromosome misalignment and spindle defects in mouse oocytes |
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