Vitamin B1 deficiency inhibits the increased conversion of tryptophan to nicotinamide in severe food-restricted rats
The conversion of tryptophan (Trp) → nicotinamide (Nam) is an important pathway for supplying vitamin niacin. We reported the following two phenomena: (1) severe food restriction led to an increase in the Trp → Nam conversion compared with free-access control group; (2) the conversion of Trp → Nam i...
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| Veröffentlicht in: | Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2015, Vol.79 (1), p.103-108 |
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| container_title | Bioscience, biotechnology, and biochemistry |
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| creator | Shibata, Katsumi Kobayashi, Ryoko Fukuwatari, Tsutomu |
| description | The conversion of tryptophan (Trp) → nicotinamide (Nam) is an important pathway for supplying vitamin niacin. We reported the following two phenomena: (1) severe food restriction led to an increase in the Trp → Nam conversion compared with free-access control group; (2) the conversion of Trp → Nam is also increased by vitamin B
1
deficiency compared with free-access control group. The present study was done to clarify whether or not a true reason about an increase in the Trp → Nam conversion is a vitamin B
1
deficiency or severe food restriction. The present results showed that vitamin B
1
deficiency suppressed the increased conversion of Trp → Nam induced by severe food restriction, probably by suppressing 3-hydroxyanthranilic acid 3,4-dioxygenase protein synthesis in liver.
Vitamin B
1
deficiency inhibits the increased conversion of tryptophan to nicotinamide in severe food-restricted rats (pair-fed control rats) |
| doi_str_mv | 10.1080/09168451.2014.962473 |
| format | Article |
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1
deficiency compared with free-access control group. The present study was done to clarify whether or not a true reason about an increase in the Trp → Nam conversion is a vitamin B
1
deficiency or severe food restriction. The present results showed that vitamin B
1
deficiency suppressed the increased conversion of Trp → Nam induced by severe food restriction, probably by suppressing 3-hydroxyanthranilic acid 3,4-dioxygenase protein synthesis in liver.
Vitamin B
1
deficiency inhibits the increased conversion of tryptophan to nicotinamide in severe food-restricted rats (pair-fed control rats)</description><identifier>ISSN: 0916-8451</identifier><identifier>EISSN: 1347-6947</identifier><identifier>DOI: 10.1080/09168451.2014.962473</identifier><identifier>PMID: 25253514</identifier><language>eng</language><publisher>England: Taylor & Francis</publisher><subject>3-Hydroxyanthranilate 3,4-Dioxygenase - biosynthesis ; 3-Hydroxyanthranilic Acid - metabolism ; Animals ; Food Deprivation ; food restriction ; Liver - metabolism ; Liver - pathology ; Male ; Niacin - metabolism ; Niacinamide - metabolism ; nicotinamide ; Protein Biosynthesis ; rat ; Rats ; Rats, Wistar ; Thiamine - metabolism ; tryptophan ; Tryptophan - metabolism ; vitamin B ; Vitamin B Deficiency - metabolism ; Vitamin B Deficiency - pathology</subject><ispartof>Bioscience, biotechnology, and biochemistry, 2015, Vol.79 (1), p.103-108</ispartof><rights>2014 Japan Society for Bioscience, Biotechnology, and Agrochemistry 2014</rights><rights>2015 Japan Society for Bioscience, Biotechnology, and Agrochemistry 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c408t-13675a9b7af374994aa37bb7d84cdcff9a65ff98a7626937bc63b94c295e43363</citedby><cites>FETCH-LOGICAL-c408t-13675a9b7af374994aa37bb7d84cdcff9a65ff98a7626937bc63b94c295e43363</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,4025,27927,27928,27929</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25253514$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shibata, Katsumi</creatorcontrib><creatorcontrib>Kobayashi, Ryoko</creatorcontrib><creatorcontrib>Fukuwatari, Tsutomu</creatorcontrib><title>Vitamin B1 deficiency inhibits the increased conversion of tryptophan to nicotinamide in severe food-restricted rats</title><title>Bioscience, biotechnology, and biochemistry</title><addtitle>Biosci Biotechnol Biochem</addtitle><description>The conversion of tryptophan (Trp) → nicotinamide (Nam) is an important pathway for supplying vitamin niacin. We reported the following two phenomena: (1) severe food restriction led to an increase in the Trp → Nam conversion compared with free-access control group; (2) the conversion of Trp → Nam is also increased by vitamin B
1
deficiency compared with free-access control group. The present study was done to clarify whether or not a true reason about an increase in the Trp → Nam conversion is a vitamin B
1
deficiency or severe food restriction. The present results showed that vitamin B
1
deficiency suppressed the increased conversion of Trp → Nam induced by severe food restriction, probably by suppressing 3-hydroxyanthranilic acid 3,4-dioxygenase protein synthesis in liver.
Vitamin B
1
deficiency inhibits the increased conversion of tryptophan to nicotinamide in severe food-restricted rats (pair-fed control rats)</description><subject>3-Hydroxyanthranilate 3,4-Dioxygenase - biosynthesis</subject><subject>3-Hydroxyanthranilic Acid - metabolism</subject><subject>Animals</subject><subject>Food Deprivation</subject><subject>food restriction</subject><subject>Liver - metabolism</subject><subject>Liver - pathology</subject><subject>Male</subject><subject>Niacin - metabolism</subject><subject>Niacinamide - metabolism</subject><subject>nicotinamide</subject><subject>Protein Biosynthesis</subject><subject>rat</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Thiamine - metabolism</subject><subject>tryptophan</subject><subject>Tryptophan - metabolism</subject><subject>vitamin B</subject><subject>Vitamin B Deficiency - metabolism</subject><subject>Vitamin B Deficiency - pathology</subject><issn>0916-8451</issn><issn>1347-6947</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkMtu3CAYRlHUKJlc3qCKWHbjCZibWUVplEulSN2k3SKMQUNlgwNMq3n7YjnpssoGBJzv-9EB4DNGW4w6dI0k5h1leNsiTLeSt1SQI7DBhIqGSyo-gc2CNAtzCs5y_oVQvWD4BJy2rGWEYboB5acvevIBfsVwsM4bb4M5QB92vvclw7Kz9WCS1dkO0MTw26bsY4DRwZIOc4nzTgdYIgzexOJDLRuWCMy2oha6GIcm2VySN6VWJF3yBTh2esz28m0_Bz8e7l_unprn74_f7m6fG0NRVxpMuGBa9kI7IqiUVGsi-l4MHTWDcU5qzuraacFbLuuT4aSX1LSSWUoIJ-fgy9o7p_i6r39Qk8_GjqMONu6zwpy1RLYYiYrSFTUp5pysU3Pyk04HhZFafKt332rxrVbfNXb1NmHfT3b4F3oXXIHrFYj7-aOVN2vCBxfTpP_ENA6q6MMYk0s6GJ8V-W_DX3NLnig</recordid><startdate>2015</startdate><enddate>2015</enddate><creator>Shibata, Katsumi</creator><creator>Kobayashi, Ryoko</creator><creator>Fukuwatari, Tsutomu</creator><general>Taylor & Francis</general><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2015</creationdate><title>Vitamin B1 deficiency inhibits the increased conversion of tryptophan to nicotinamide in severe food-restricted rats</title><author>Shibata, Katsumi ; Kobayashi, Ryoko ; Fukuwatari, Tsutomu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c408t-13675a9b7af374994aa37bb7d84cdcff9a65ff98a7626937bc63b94c295e43363</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>3-Hydroxyanthranilate 3,4-Dioxygenase - biosynthesis</topic><topic>3-Hydroxyanthranilic Acid - metabolism</topic><topic>Animals</topic><topic>Food Deprivation</topic><topic>food restriction</topic><topic>Liver - metabolism</topic><topic>Liver - pathology</topic><topic>Male</topic><topic>Niacin - metabolism</topic><topic>Niacinamide - metabolism</topic><topic>nicotinamide</topic><topic>Protein Biosynthesis</topic><topic>rat</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Thiamine - metabolism</topic><topic>tryptophan</topic><topic>Tryptophan - metabolism</topic><topic>vitamin B</topic><topic>Vitamin B Deficiency - metabolism</topic><topic>Vitamin B Deficiency - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shibata, Katsumi</creatorcontrib><creatorcontrib>Kobayashi, Ryoko</creatorcontrib><creatorcontrib>Fukuwatari, Tsutomu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Bioscience, biotechnology, and biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shibata, Katsumi</au><au>Kobayashi, Ryoko</au><au>Fukuwatari, Tsutomu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vitamin B1 deficiency inhibits the increased conversion of tryptophan to nicotinamide in severe food-restricted rats</atitle><jtitle>Bioscience, biotechnology, and biochemistry</jtitle><addtitle>Biosci Biotechnol Biochem</addtitle><date>2015</date><risdate>2015</risdate><volume>79</volume><issue>1</issue><spage>103</spage><epage>108</epage><pages>103-108</pages><issn>0916-8451</issn><eissn>1347-6947</eissn><abstract>The conversion of tryptophan (Trp) → nicotinamide (Nam) is an important pathway for supplying vitamin niacin. We reported the following two phenomena: (1) severe food restriction led to an increase in the Trp → Nam conversion compared with free-access control group; (2) the conversion of Trp → Nam is also increased by vitamin B
1
deficiency compared with free-access control group. The present study was done to clarify whether or not a true reason about an increase in the Trp → Nam conversion is a vitamin B
1
deficiency or severe food restriction. The present results showed that vitamin B
1
deficiency suppressed the increased conversion of Trp → Nam induced by severe food restriction, probably by suppressing 3-hydroxyanthranilic acid 3,4-dioxygenase protein synthesis in liver.
Vitamin B
1
deficiency inhibits the increased conversion of tryptophan to nicotinamide in severe food-restricted rats (pair-fed control rats)</abstract><cop>England</cop><pub>Taylor & Francis</pub><pmid>25253514</pmid><doi>10.1080/09168451.2014.962473</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Bioscience, biotechnology, and biochemistry, 2015, Vol.79 (1), p.103-108 |
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| language | eng |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); Freely Accessible Japanese Titles; EZB-FREE-00999 freely available EZB journals |
| subjects | 3-Hydroxyanthranilate 3,4-Dioxygenase - biosynthesis 3-Hydroxyanthranilic Acid - metabolism Animals Food Deprivation food restriction Liver - metabolism Liver - pathology Male Niacin - metabolism Niacinamide - metabolism nicotinamide Protein Biosynthesis rat Rats Rats, Wistar Thiamine - metabolism tryptophan Tryptophan - metabolism vitamin B Vitamin B Deficiency - metabolism Vitamin B Deficiency - pathology |
| title | Vitamin B1 deficiency inhibits the increased conversion of tryptophan to nicotinamide in severe food-restricted rats |
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