Four structural risk factors identify most fibril-forming kappa light chains

Antibody light chains (LCs) comprise the most structurally diverse family of proteins involved in amyloidosis. Many antibody LCs incorporate structural features that impair their stability and solubility, leading to their assembly into fibrils and to their subsequent pathological deposition when pro...

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Bibliographische Detailangaben
Veröffentlicht in:	Amyloid 2000, Vol.7 (3), p.200-211
1. Verfasser:	Stevens, Fred J.
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Alzheimer Disease - metabolism Amino Acid Substitution AMINO ACIDS Amyloid - chemistry Amyloidosis - metabolism ANTIBODIES BASIC BIOLOGICAL SCIENCES CHAINS Databases, Factual fibril formation Glycosylation Humans IMMUNE SYSTEM DISEASES Immunoglobulin kappa-Chains - chemistry Immunoglobulin kappa-Chains - genetics MUTATIONS myelin protein zero Myeloma Proteins - chemistry Myeloma Proteins - genetics PATIENTS Point Mutation Protein Processing, Post-Translational PROTEINS RESIDUES Risk Factors SOLUBILITY somatic mutation STABILITY variable domain VARIATIONS
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