MASPIC: Intensity-Based Tandem Mass Spectrometry Scoring Scheme That Improves Peptide Identification at High Confidence

Algorithmic search engines bridge the gap between large tandem mass spectrometry data sets and the identification of proteins associated with biological samples. Improvements in these tools can greatly enhance biological discovery. We present a new scoring scheme for comparing tandem mass spectra wi...

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Veröffentlicht in:	Analytical chemistry (Washington) 2005-12, Vol.77 (23), p.7581-7593
Hauptverfasser:	Narasimhan, Chandrasegaran, Tabb, David L, VerBerkmoes, Nathan C, Thompson, Melissa R, Hettich, Robert L, Uberbacher, Edward C
Format:	Artikel
Sprache:	eng
Schlagworte:	ALGORITHMS Amino Acid Sequence Analytical chemistry BASIC BIOLOGICAL SCIENCES Chemistry DATA PROCESSING DISTRIBUTION Endopeptidase K - chemistry Endopeptidase K - metabolism Exact sciences and technology MASS SPECTRA MASS SPECTROSCOPY Methods MIXTURES Molecular Sequence Data PEPTIDES Peptides - analysis Peptides - chemistry PROBABILITY PROTEINS RHODOPSEUDOMONAS Rhodopseudomonas - chemistry Ribosomes - chemistry Scientific imaging SPECTRA Spectrometric and optical methods Tandem Mass Spectrometry - methods
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