Functional and evolutionary analyses on expressed intronless genes in the mouse genome
Using computational approaches we have identified 2017 expressed intronless genes in the mouse genome. Evolutionary analysis reveals that 56 intronless genes are conserved among the three domains of life – bacteria, archea and eukaryotes. These highly conserved intronless genes were found to be invo...
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| Veröffentlicht in: | FEBS letters 2006-02, Vol.580 (5), p.1472-1478 |
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| container_title | FEBS letters |
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| creator | Sakharkar, Kishore Ramaji Sakharkar, Meena Kishore Culiat, Cymbeline T. Chow, Vincent T.K. Pervaiz, Shazib |
| description | Using computational approaches we have identified 2017 expressed intronless genes in the mouse genome. Evolutionary analysis reveals that 56 intronless genes are conserved among the three domains of life – bacteria, archea and eukaryotes. These highly conserved intronless genes were found to be involved in essential housekeeping functions. About 80% of expressed mouse intronless genes have orthologs in eukaryotic genomes only, and thus are specific to eukaryotic organisms. 608 of these genes have intronless human orthologs and 302 of these orthologs have a match in OMIM database. Investigation into these mouse genes will be important in generating mouse models for understanding human diseases. |
| doi_str_mv | 10.1016/j.febslet.2006.01.070 |
| format | Article |
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| source | Wiley-Blackwell Journals; MEDLINE; Elsevier ScienceDirect Journals Complete; Wiley Free Archive; Alma/SFX Local Collection; EZB Electronic Journals Library |
| subjects | Animals BACTERIA BASIC BIOLOGICAL SCIENCES Databases, Nucleic Acid DISEASES Evolution, Molecular FUNCTIONALS GENES Genes - physiology Genome Housekeeping Human disease Humans Intronless INTRONS Mice - genetics Mouse models Ortholog Sequence Homology Single exonic genes Species Specificity |
| title | Functional and evolutionary analyses on expressed intronless genes in the mouse genome |
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