Structural and Biochemical Analyses of Shikimate Dehydrogenase AroE from Aquifex aeolicus: Implications for the Catalytic Mechanism

The shikimate biosynthetic pathway is essential to microorganisms, plants, and parasites but absent from mammals. Therefore, shikimate dehydrogenase (SD) and other enzymes in the pathway are attractive targets for developing nontoxic antimicrobial agents, herbicides, and antiparasite drugs. SD catal...

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Veröffentlicht in:	Biochemistry (Easton) 2007-08, Vol.46 (33), p.9513-9522
Hauptverfasser:	Gan, Jianhua, Wu, Yan, Prabakaran, Ponraj, Gu, Yijun, Li, Yue, Andrykovitch, Michelle, Liu, Hehua, Gong, Yunchen, Yan, Honggao, Ji, Xinhua
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcohol Oxidoreductases - chemistry Alcohol Oxidoreductases - genetics Amino Acid Sequence ANTIMICROBIAL AGENTS Aquifex aeolicus Bacterial Proteins - chemistry Bacterial Proteins - genetics Binding Sites Catalysis Catalytic Domain CRYSTAL STRUCTURE Crystallography, X-Ray DATA DRUGS ENZYMES HERBICIDES MAMMALS MATERIALS SCIENCE MICROORGANISMS NADP NADP - chemistry national synchrotron light source OXIDOREDUCTASES PARASITES PLANTS Protein Conformation REDUCTION SHIKIMIC ACID Shikimic Acid - chemistry
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