Crystal Structure of Thermus aquaticus Gfh1, a Gre-factor Paralog that Inhibits rather than Stimulates Transcript Cleavage

Transcription elongation in bacteria is promoted by Gre-factors, which stimulate an endogenous, endonucleolytic transcript cleavage activity of the RNA polymerase. A GreA paralog, Gfh1, present in Thermus aquaticus and Thermus thermophilus, has the opposite effect on elongation complexes, inhibiting...

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Veröffentlicht in:	Journal of molecular biology 2006-02, Vol.356 (1), p.179-188
Hauptverfasser:	Lamour, Valerie, Hogan, Brian P., Erie, Dorothy A., Darst, Seth A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Bacterial Proteins - chemistry Bacterial Proteins - genetics Bacterial Proteins - metabolism CLEAVAGE CONFORMATIONAL CHANGES Conserved Sequence CRYSTAL STRUCTURE Crystallography, X-Ray DNA-Directed RNA Polymerases - antagonists & inhibitors DNA-Directed RNA Polymerases - genetics DNA-Directed RNA Polymerases - metabolism FUNCTIONAL ANALYSIS Gene Expression Regulation, Bacterial Gfh1 Gre-factors MAGNESIUM IONS MATERIALS SCIENCE Molecular Sequence Data national synchrotron light source Protein Structure, Tertiary RNA RNA polymerase RNA POLYMERASES RNA Processing, Post-Transcriptional RNA, Bacterial - genetics RNA, Bacterial - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism Sequence Alignment Sequence Homology, Amino Acid Static Electricity Structural Homology, Protein Thermus - chemistry Thermus - genetics Thermus aquaticus Thermus thermophilus transcription elongation Transcription, Genetic
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