Three-Dimensional Mapping of Ozone-Induced Injury in the Nasal Airways of Monkeys Using Magnetic Resonance Imaging and Morphometric Techniques

Age-related changes in gross and microscopic structure of the nasal cavity may alter local tissue susceptibility as well as the dose of inhaled toxicant delivered to susceptible sites. This article describes a novel method for the use of magnetic resonance imaging, 3-dimensional airway modeling, and...

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Veröffentlicht in:	Toxicologic pathology 2007-01, Vol.35 (1), p.27-40
Hauptverfasser:	Carey, Stephan A., Minard, Kevin R., Trease, Lynn L., Wagner, James G., Garcia, Guilherme J. M., Ballinger, Carol A., Kimbell, Julia S., Plopper, Charles G., Corley, Richard A., Postlethwait, Edward M., Harkema, Jack R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals BASIC BIOLOGICAL SCIENCES Biological and medical sciences BIOLOGICAL EFFECTS Computational Biology - methods computational gluid dynamics DOSE-RESPONSE RELATIONSHIPS Imaging, Three-Dimensional INJURIES Macaca mulatta MAGNETIC RESONANCE Magnetic Resonance Imaging Male MAPPING Medical sciences MONKEYS morphometry Nasal Cavity - drug effects Nasal Cavity - pathology Nasal Mucosa - drug effects Nasal Mucosa - pathology nasal toxicology NECROSIS NOSE Oxidants, Photochemical - adverse effects OZONE Ozone - adverse effects Rhinitis - chemically induced Rhinitis - pathology Toxicology Turbinates - drug effects Turbinates - pathology
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