X-Ray Structure of a Rex-Family Repressor/NADH Complex Insights into the Mechanism of Redox Sensing

The redox-sensing repressor Rex regulates transcription of respiratory genes in response to the intra cellular NADH/NAD + redox poise. As a step toward elucidating the molecular mechanism of NADH/NAD + sensing, the X-ray structure of Thermus aquaticus Rex (T-Rex) bound to effector NADH has been dete...

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Veröffentlicht in:	Chemistry of materials 2005, Vol.13 (1), p.43-54
Hauptverfasser:	Sickmier, E. Allen, Brekasis, Dimitris, Paranawithana, Shanthi, Bonanno, Jeffrey B., Paget, Mark S.B., Burley, Stephen K., Kielkopf, Clara L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Motifs Amino Acid Sequence BASIC BIOLOGICAL SCIENCES Binding Sites COENZYMES COMPLEXES Conserved Sequence Crystallography, X-Ray DETECTION Dimerization DNA - chemistry DNA - metabolism Electrophoretic Mobility Shift Assay Escherichia coli - genetics Gene Products, rex - chemistry Gene Products, rex - genetics Hydrophobic and Hydrophilic Interactions Models, Molecular Molecular Sequence Data NAD - metabolism national synchrotron light source Operon Oxidation-Reduction Protein Conformation Protein Structure, Secondary Protein Structure, Tertiary REDOX REACTIONS Repressor Proteins - chemistry Repressor Proteins - genetics Repressor Proteins - isolation & purification Repressor Proteins - metabolism Sequence Homology, Amino Acid Surface Plasmon Resonance Thermus - chemistry Thermus aquaticus X-RAY DIFFRACTION
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